Abstract
Adhesion is essential to amny aspects of the T cell phsiology. Although initially it seemed plausible that this would be mediated by only a few molecules, it is now apparent that there are many adhesion molecules on T cells. Resting T cells have more than dozen, activated cells more than two dozen, and more will undoubtedly be discovered. The challenge is to find simplifying paradigms to understand similarities and differneces between these molecules and elucidate general principles by which they fucntion. One such important concept which has emerged is that of adhesion cascades.
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Abbreviations
- CD44 :
-
Cluster Determinant-44;
- GAG :
-
Glycosaminoglycan;
- HEV :
-
High En-dothelial Venules;
- IL8 :
-
Interleukin-8;
- mAb :
-
Monoclonal Antibody;
- TGFβ:
-
Transforming Growth Factor-β;
- VCAM-1 :
-
Vascular Cell Adhesion Molecule-1
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© 1993 Plenum Press, New York
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Tanaka, Y., Adams, D.H., Schweighoffer, T., Shaw, S. (1993). Regulation of T Cell Adhesion with T Cell Differentiation and with Acute Activation by Mip-lβ Cytokine Immobilized on CD44 Proteoglycan. In: Hemler, M.E., Mihich, E. (eds) Cell Adhesion Molecules. Pezcoller Foundation Symposia, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2830-2_11
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DOI: https://doi.org/10.1007/978-1-4615-2830-2_11
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