Abstract
Age-dependent changes in neuronal membrane composition and function have been described, and a widely accepted “membrane hypothesis of aging” has been proposed to explain the decay of cerebral performance in old age (Sun and Sun, 1979). Among the agedependent changes which affect the composition and function of the neuronal membrane is an increased cholesterol-to-phospholipid molar ratio, a reduction of enzymatic activities and decreased efficiency of signal transduction mechanisms (Schroeder, 1984).
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Nunzi, M.G., Toffano, G. (1992). Pharmacological Effects of Phosphatidylserine in the Aging Rat Brain. In: Meyer, E.M., Simpkins, J.W., Yamamoto, J., Crews, F.T. (eds) Treatment of Dementias. Advances in Behavioral Biology, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3432-7_16
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