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Transforming Growth Facfors in Human Prostate Cancer

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Molecular and Cellular Biology of Prostate Cancer

Abstract

Control of epithelial cell growth is poorly understood. Most epithelial cells exist in a tightly controlled state maintained by a balance between the effects of stimulatory and inhibitory factors. Holley proposed that transformed cells escape this control and require less exogenous growth factors in culture than their normal counterparts (1). This observation formed the basis of the autocrine growth control hypothesis whereby transformed cells produce and respond to their own growth factors (2,3).

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Author information

Authors and Affiliations

  1. Department of Human Oncology, University of Wisconsin Clinical Cancer Center, K4/666 CSC 600 Highland Avenue, Madison, Wisconsin, 53792, USA

    George Wilding

  2. Wm. S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, Wisconsin, 53705, USA

    George Wilding

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  1. George Wilding
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Editor information

Editors and Affiliations

  1. Office of Scientific Administration, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA

    James P. Karr Ph.D. (Chief) (Chief)

  2. The Johns Hopkins Hospital and University, Marburg Building, 600 North Wolfe Street, Baltimore, MD, 21205, USA

    Donald S. Coffey Ph.D. (Professor of Urology, Oncology and Pharmacology) (Professor of Urology, Oncology and Pharmacology)

  3. Department of Growth Biochemistry and Physiology, Merck, Sharpe and Dohme Research Lab, 126 East Lincoln Avenue, Rahway, NJ, 07065, USA

    Roy G. Smith Ph.D.

  4. Mayo Clinic, Guggenheim-4 200 First Street, SW, Rochester, MN, 55905, USA

    Donald J. Tindall Ph.D. (Professor of Urologic Research) (Professor of Urologic Research)

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Wilding, G. (1991). Transforming Growth Facfors in Human Prostate Cancer. In: Karr, J.P., Coffey, D.S., Smith, R.G., Tindall, D.J. (eds) Molecular and Cellular Biology of Prostate Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3704-5_16

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  • DOI: https://doi.org/10.1007/978-1-4615-3704-5_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6647-8

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