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Lymphocyte-Mediated Cytolysis Role of Granule Mediators

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Blood Cell Biochemistry Volume 3

Part of the book series: Blood Cell Biochemistry ((BLBI,volume 3))

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Abstract

Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells represent the two main effector lymphocyte populations thought to be involved in killing virus-infected and transformed cells (reviewed in Berke, 1983; Herberman et al., 1986; Trinchieri and Perussia, 1984; Goldfarb, 1986). Killing by lymphocytes is known to require a contact-dependent mechanism. Although the precise mechanisms by which lymphocytes kill their targets are still unclear, a large body of information has recently accumulated on various mediators that may play a direct role in lymphocyte-mediated killing. This information will be reviewed briefly here.

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Authors and Affiliations

  1. Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York, 10021, USA

    John Ding-E Young & Chau-Ching Liu

  2. Department of Microbiology and Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, 46223, USA

    Byoung S. Kwon

  3. Laboratory of Human Immunogenetics, Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, USA

    Joseph A. Trapani

  4. The Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, 02114, USA

    Lucy H. Y. Young

Authors
  1. John Ding-E Young
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  2. Chau-Ching Liu
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  3. Byoung S. Kwon
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  4. Joseph A. Trapani
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  5. Lucy H. Y. Young
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Editors and Affiliations

  1. North East Thames Regional Transfusion Centre, Brentwood, Essex, England

    J. R. Harris

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Young, J.DE., Liu, CC., Kwon, B.S., Trapani, J.A., Young, L.H.Y. (1991). Lymphocyte-Mediated Cytolysis Role of Granule Mediators. In: Harris, J.R. (eds) Blood Cell Biochemistry Volume 3. Blood Cell Biochemistry, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3796-0_6

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  • DOI: https://doi.org/10.1007/978-1-4615-3796-0_6

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