Abstract
The influence of maternal immunologic reactivity on the development of the immunologic repertoire in the neonate has been examined in a number of recent studies employing different antigens in a variety of mammalian species1,2. Studies carried out by Jarrett and Ha113 in rats have shown that maternal immunization with ovalbumin (OVA) administered parenterally prior to mating is associated with significant suppression of IgE and enhancement of IgG anti-OVA response in the neonate following neonatal immunization. Significant suppression of neonatal immune response has also been observed after oral immunization of pregnant rabbits with bovine serum albumin4. Other studies have suggested a potential for enhanced neonatal immune response after prior maternal immunization5. The mechanisms underlying the maternally induced alterations in neonatal immune response remain to be determined. The relative contribution of transplacentally-acquired or breastfeeding-related maternal components in such effects is not known. The present studies were undertaken in order to characterize the nature of neonatal immune response to antigens and to evaluate the role of breastfeeding in such maternal-neonatal interactions.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
N. Yamaguchi, S. Shimizu, A. Hara, and T. Saito, Immunology 50: 229 (1983).
W. Müller, A. Lippman., and C. H. L. Rieger, Pediat. Res. 17: 724 (1983).
E. Jarrett and E. Hall Nature 280:145 (1979).
B. A. Peri and R. M. Rothberg J. Immunol. 127:2520 (1981).
H. Tsutsumi, T. Flanagan, and P. L. Ogra J. Gen. Virol.68:2111 (1987)
C. Bona, R. Hooghe, P. A. Cazenave, C. Leguern, and W. E. Paul J. Exp. Med.149:815 (1979).
S. S. Ogra, D. Weintraub, and P. L. Ogra J. Immunol.119:245 (1977)
J. C. Leissring, Amer. J. Dis. Child. 103: 160 (1962).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Okamoto, Y. (1991). Maternal Determinants of Neonatal Immune Response: Effect of Anti-Idiotype in the Neonate. In: Mestecky, J., Blair, C., Ogra, P.L. (eds) Immunology of Milk and the Neonate. Advances in Experimental Medicine and Biology, vol 310. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3838-7_28
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3838-7_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6713-0
Online ISBN: 978-1-4615-3838-7
eBook Packages: Springer Book Archive