Abstract
Mutagenic effects may arise from direct interaction of chemical and physical agents with DNA, from errors which occur during self-replication, from interference with nuclear division and from perturbations in DNA precursor pools (1). Cytosolic thymidine kinase (TK), a pyrimidine nucleotide salvage pathway enzyme closely associated with DNA synthesis has been found in Friend mouse leukemia (FEL) cells to influence sensitivity to mutagenic agents.
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© 1991 Springer Science+Business Media New York
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McKenna, P.G., Wilkinson, Y.A., McKelvey, V.J. (1991). The Significance of Thymidine Kinase in Determining Resistance to Mutagenesis in Friend Mouse Leukemia Cells. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_10
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DOI: https://doi.org/10.1007/978-1-4615-3850-9_10
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