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Oxidative Substrate Metabolism in Reperfused Myocardium

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Cardiac Electrophysiology, Circulation, and Transport

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 121))

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Abstract

The oxidative metabolic rate in retrogradely perfused isolated rat hearts is exceedingly high relative to contractile performance early after postischemic reperfusion. This hypermetabolism is not only observed in hearts that were reversibly “stunned” but also in hearts that were irreversibly injured after one hour of reperfusion. The dissociation between contractile function and oxygen consumption decreases during administration of ruthenium red, compatible with the involvement of mitochondrial calcium transport in the mechanisms of postischemic hypermetabolism.

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Authors
  1. Rene Lerch
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  2. Gunter Goerge
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  3. Richard Benzi
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Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering, The Julius Silver Institute, Haifa, Israel

    Samuel Sideman D.Sc. (R.J. Matas Winnipeg Professor of Biomedical Engineering, Head, Distinguished Visiting Professor) & Rafael Beyar M.D., D.Sc. (Associate Professor, Associate Head) (R.J. Matas Winnipeg Professor of Biomedical Engineering, Head, Distinguished Visiting Professor) &  (Associate Professor, Associate Head)

  2. Cardiac System Research Center, Technion-Israel Institute of Technology, Haifa, Israel

    Samuel Sideman D.Sc. (R.J. Matas Winnipeg Professor of Biomedical Engineering, Head, Distinguished Visiting Professor) & Rafael Beyar M.D., D.Sc. (Associate Professor, Associate Head) (R.J. Matas Winnipeg Professor of Biomedical Engineering, Head, Distinguished Visiting Professor) &  (Associate Professor, Associate Head)

  3. Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, USA

    Samuel Sideman D.Sc. (R.J. Matas Winnipeg Professor of Biomedical Engineering, Head, Distinguished Visiting Professor) (R.J. Matas Winnipeg Professor of Biomedical Engineering, Head, Distinguished Visiting Professor)

  4. Department of Physiology, University of Bern, Bern, Switzerland

    André G. Kléber M.D. (Professor) (Professor)

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© 1991 Springer Science+Business Media Dordrecht

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Lerch, R., Goerge, G., Benzi, R. (1991). Oxidative Substrate Metabolism in Reperfused Myocardium. In: Sideman, S., Beyar, R., Kléber, A.G. (eds) Cardiac Electrophysiology, Circulation, and Transport. Developments in Cardiovascular Medicine, vol 121. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3894-3_32

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  • DOI: https://doi.org/10.1007/978-1-4615-3894-3_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6737-6

  • Online ISBN: 978-1-4615-3894-3

  • eBook Packages: Springer Book Archive

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