Abstract
It will be evident to the reader, from other chapters in this book, that Graves’ Disease (GD) is polygenic and multifactorial, a combination which makes unravelling relevant pathogenic mechanisms exceedingly difficult. GD is very common but patients present when disease has advanced to the extent of causing clinical signs and symptoms, which is likely to be temporally removed from the initiating immune events. Thus it has long been recognized that fundamental progress in our understanding of GD would benefit from an appropriate animal model.
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Ludgate, M., Costagliola, S., Vassart, G. (2000). Animal Models of Graves’ Disease. In: Rapoport, B., McLachlan, S.M. (eds) Graves’ Disease. Endocrine Updates, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4407-4_9
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DOI: https://doi.org/10.1007/978-1-4615-4407-4_9
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