Abstract
The principle of isotope dilution assay (IDA) was first reported by Rittenberg & Foster (1940) for the analysis of fatty acids and amino acids in complex mixtures. Sweely and coworkers (1966) used deuterated glucose for the determination of glucose in plant tissues. IDA has been proposed as a reference method in clinical chemistry (Björkhem et al., 1976). The theoretical basis of IDA was established by Pickup and McPherson (1976). De Bièvre (1990) and Sabot (1994) have recently published reviews on this technique.
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Blank, I., Milo, C., Lin, J., Fay, L.B. (1999). Quantification of Aroma-Impact Components by Isotope Dilution Assay—Recent Developments. In: Teranishi, R., Wick, E.L., Hornstein, I. (eds) Flavor Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4693-1_7
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