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Chromium(III) as a Male Preconception Carcinogen in Mice

  • Chapter
Metals and Genetics

Abstract

Numerous epidemiological studies have suggested significant correlation between paternal exposure to chemical carcinogens or radiation and incidence of childhood cancers, including brain tumor, Wilm’ tumor of kidney, leukemia, hepatoblastoma, retinoblastoma and sarcoma in soft tissues (Savitz and Chen, 1990; Olsen et al., 1991; Bunin et al, 1992; Tomatis, 1994). Interpretations of some of these data have been controversial, particularly with regard to radiation effects. However, recently several very large studies of paternal smoking, conducted in different parts of the world, have established associations between paternal preconception smoking levels and risk of cancer in children, with a high degree of statistical significance (Sorahan et al, 1997a and b; Ji et al., 1997). These results provide strong confirmation that preconception carcinogenesis does occur in humans.

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Authors and Affiliations

  1. Laboratory of Comparative Carcinogenesis Division of Basic Sciences, National Cancer Institute, USA

    Lucy M. Anderson, Marek A. Sipowicz, Wei Yu & Kazimierz S. Kasprzak

  2. SAIC-Frederick, Inc., USA

    Bhalchandra A. Diwan, Lisa Birely & Diana C. Haines

  3. Data Management Services, Inc. Frederick Cancer Research and Development Center, Frederick, Maryland, 21702, USA

    Charles W. Riggs

Authors
  1. Lucy M. Anderson
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  2. Marek A. Sipowicz
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  3. Wei Yu
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  4. Bhalchandra A. Diwan
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  8. Kazimierz S. Kasprzak
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  1. The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada

    Bibudhendra Sarkar

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Anderson, L.M. et al. (1999). Chromium(III) as a Male Preconception Carcinogen in Mice. In: Sarkar, B. (eds) Metals and Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4723-5_12

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  • DOI: https://doi.org/10.1007/978-1-4615-4723-5_12

  • Publisher Name: Springer, Boston, MA

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