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Metalloregulation of Soft Metal Resistance Pumps

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Metals and Genetics

Abstract

Many metals are required for cellular growth. Others, such as cadmium, lead, arsenic and antimony, are toxic. Some, such as zinc and copper, are both micronutrients but toxic in excess. For these processes cells must contain both uptake and efflux systems. Perhaps due to geochemical sources of metals, bacterial resistances to metals probably arose early in evolution. Before the modern use of antibiotics, bacterial metal resistance determinants encoding extrusion systems were more widespread than antibiotic resistances (Datta and Hughes, 1983).

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine Detroit, Michigan, 48201, USA

    Chun Xu & Barry P. Rosen

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  1. Chun Xu
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  2. Barry P. Rosen
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Editors and Affiliations

  1. The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada

    Bibudhendra Sarkar

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© 1999 Springer Science+Business Media New York

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Xu, C., Rosen, B.P. (1999). Metalloregulation of Soft Metal Resistance Pumps. In: Sarkar, B. (eds) Metals and Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4723-5_2

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  • DOI: https://doi.org/10.1007/978-1-4615-4723-5_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7140-3

  • Online ISBN: 978-1-4615-4723-5

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