Abstract
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants formed primarily from the incomplete combustion of organic material. They are present in tobacco smoke, exhaust fumes and urban air. PAHs are also found in water and soil as a result the rain and gravitational influence providing other possible routes for human exposure (Wills and Weisburger, 1986). Benzo[a]pyrene (BP) is a potent inducer of drug- metabolizing enzymes. BP up-regulates the expression of [Ah] battery genes, by binding to the aryl-hydrocarbon receptor (AHR) (Nebert et al., 1993). The [Ah] battery consists of at least six genes: two Phase I (CYP1 Al and CYP1A2) and four Phase II genes (ALDH3, NQO-1,T1*A6 and GSTA-1). Induction of CYP1A1 and CYP1A2 enzymes provokes increased metabolic activation of PAHs to mutagenic derivatives that may activate pro- or inactivate tumor or inactivate tumor supressor genes (Nebert, 1989; Hankinson, 1995). On the other d, induction of the Phase II enzymes of the [Ah] gene battery may be beneficial, since se enzymes are involved in detoxification pathways.
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Stephanou, P., Pappas, P., Vasiliou, V., Marselos, M. (1999). Prepubertal Regulation of the Rat Dioxin-Inducible Aldehyde Dehydrogenase (ALDH3). In: Weiner, H., Maser, E., Crabb, D.W., Lindahl, R. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 7. Advances in Experimental Medicine and Biology, vol 463. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4735-8_17
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DOI: https://doi.org/10.1007/978-1-4615-4735-8_17
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