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Increased Perfusion Via Laser-mediated Myocardial Channels?

Importance of Appropriate Models and Endpoints

  • Chapter
Direct Myocardial Revascularization: History, Methodology, Technology

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 211))

Abstract

Laser-mediated transmural myocardial revascularization (TMR) is being hailed as a promising new strategy for relieving myocardial ischemia in patients with diffuse coronary artery disease not amenable to bypass graft surgery or angioplasty. Indeed, anecdotal case reports and small clinical studies describing the merits of laser-mediated TMR are emerging in the literature [1–5], and the results of ongoing trials evaluating the efficacy of TMR are eagerly awaited. Surprisingly, however, the fundamental premise of the method — ie. that laser-made channels serve as conduits for the transport of oxygen-rich blood from the left ventricular (LV) lumen to ischemic-but-viable myocardium, thereby restoring blood flow to the compromised tissue and resolving ischremic sequelae — has not been rigorously confirmed in either the clinical setting or under the controlled conditions of the experimental laboratory.

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Authors and Affiliations

  1. Heart Institute, Good Samaritan Hospital and Department of Medicine, Section of Cardiology, University of Southern California, Los Angeles, California, USA

    Karin Przyklenk, Robert A. Kloner & Peter Whittaker

Authors
  1. Karin Przyklenk
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  2. Robert A. Kloner
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  3. Peter Whittaker
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Peter Whittaker Ph.D. George S. Abela M.D.

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Przyklenk, K., Kloner, R.A., Whittaker, P. (1999). Increased Perfusion Via Laser-mediated Myocardial Channels?. In: Whittaker, P., Abela, G.S. (eds) Direct Myocardial Revascularization: History, Methodology, Technology. Developments in Cardiovascular Medicine, vol 211. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5069-3_4

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  • DOI: https://doi.org/10.1007/978-1-4615-5069-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7305-6

  • Online ISBN: 978-1-4615-5069-3

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