Abstract
One of the most striking features of the intraneuronal inclusions of Alzheimer (AD) and Parkinson (PD) diseases is that, although they are derived from the neuronal cytoskeleton, they are fundamentally altered. Among these alterations is their insolubility in denaturants (Selkoe et al., 1982; Galloway et al., 1992) and it is our contention that the elucidation of the posttranslational modifications responsible for insolubilization will provide a fundamental insight into the cytopathology of AD and PD.
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References
Baynes, J.W., 1991, Role of oxidative stress in development of complications in diabetes, Diabetes 40:405–412.
Bondareff, W., Harrington, C.R., Wischik, C.M., Hauser, D.L., and Roth, M., 1995, Absence of abnormal hyper-phosphorylation of tau in intracellular tangles in Alzheimer’s disease, J. Neuropathol. Exp. Neurol. 54:657–663.
Castellani, R., Smith, M.A., Richey, P.L., and Perry, G., 1996, Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease, Brain Res. 737:195–200.
Cerami, A., Vlassara, H., and Brownlee, M., 1987, Glucose and aging, Sci. Amer. 256:90–96.
Esterbauer, H., Schaur, R. J., and Zollner, H., 1991, Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes, FreeRadic. Biol Med. 11:81–128.
Friguet, B., Stadtman, E.R., and Szweda, L.I., 1994, Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease, J. Biol. Chem. 269:21639–21643.
Galloway, P.G., Mulvihill, P., and Perry, G., 1992, Filaments of Lewy bodies contain insoluble cytoskeletal elements, Am. J. Pathol. 140:809–822.
Goedert, M., Jakes, R., Crowther, R.A., Six, J., Lubke, U., Vandermeeren, M., Cras, P., Trojanowski, J.Q., and Lee, V.M., 1993, The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development, Proc. Natl. Acad. Sci. USA 90:5066–5070.
Grundke-Iqbal, I., Iqbal, K., Tung, Y.C., Quinlan, M., Wisniewski, H.M., and Binder, L.I., 1986, Abnormal phosphorylation of the microtubule-associated protein τ (tau) in Alzheimer cytoskeletal pathology, Proc. Natl. Acad. Sci. USA 83:4913–4917.
Matsuo, E.S., Shin, R.W., Billingsley, M.L., Van deVoorde, A., O’Connor, M., Trojanowski, J.Q., and Lee, V.M., 1994, Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer’s disease paired helical filament tau, Neuron 13:989–1002.
Montine, K.S., Olson, S.J., Amarnath, V., Whetsell, W.O. Jr., Graham, D.G., and Montine, T.J., 1997, Immunohis-tochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer’s disease is associated with inheritance of APOE4, Am. J. Pathol. 150:437–443.
Sayre, L.M., Zelasko, D.A., Harris, P.L.R., Perry, G., Salomon, R.G., and Smith, M.A., 1997,4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer’s disease, J. Neurochem. 68:2092–2097.
Selkoe, D.J., Ihara, Y., and Salazar, F.J., 1982, Alzheimer’s disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea, Science 215:1243–1245.
Smith, M.A., Taneda, S., Richey, P.L., Miyata, S., Yan, S.-D., Stern, D., Sayre, L.M., Monnier, V.M., and Perry, G., 1994a, Advanced Maillard reaction end products are associated with Alzheimer disease pathology, Proc. Natl. Acad. Sci. USA 91:5710–5714.
Smith, M.A., Kutty, R.K., Richey, P.L., Yan, S.-D., Stern, D., Chader, G.J., Wiggert, B., Petersen, R.B., and Perry, G., 1994b, Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer’s disease, Am. J. PathoL 145:42–47.
Smith, M.A., Siedlak, S.L., Richey, P.L., Nagaraj, R.H., Elhammer, A., and Perry, G., 1996a, Quantitative solubili-zation and analysis of insoluble paired helical filaments from Alzheimer disease, Brain Res. 717:99–108.
Smith, M.A., Perry, G., Richey, P.L., Sayre, L.M., Anderson, V.E., Beal, M.F., and Kowall, N., 1996b, Oxidative damage in Alzheimer’s, Nature 382:120–121.
Smith, M.A., Harris, P.L.R., Sayre, L.M., Beckman, J.S., and Perry, G., 1997a, Widespread peroxynitrite-mediated damage in Alzheimer’s disease, J. Neurosci. 17:2653–2657.
Smith, M.A., Harris, P.L.R., Sayre, L.M., and Perry, G., 1997b, Iron accumulation in Alzheimer disease is a source of redox-generated free radicals, Proc. Natl. Acad. Sci. USA, in press.
Sternberger, L.A. and Sternberger, N.H., 1983, Monoclonal antibodies distinguish phosphorylated and nonphos-phorylated forms of neurofilaments in situ., Proc. Natl. Acad. Sci. USA 80:6126–6130.
Sternberger, N.H., Sternberger, L.A., and Ulrich, J., 1985, Aberrant neurofilament phosphorylation in Alzheimer disease, Proc. Natl. Acad. Sci. USA 82:4274–4276.
Trojanowski, J.Q., Schmidt, M.L., Shin, R.-W, Bramblett, G.T., Goedert, M., and Lee, V.M.-Y, 1993, PHF-tau (A68): From pathological marker to potential mediator of neuronal dysfunction and degeneration in Alzheimer’s disease, Clin. Neurosci. 1:184–191.
Yan, S.-D., Chen, X., Schmidt, A.-M., Brett, J., Godman, G., Zou, Y.-S., Scott, C.W., Caputo, C., Frappier, T., Smith, M.A., Perry, G., Yen, S.-H., and Stern, D., 1994, Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress, Proc. Natl. Acad. Sci. USA 91:7787–7791.
Yan, S.D., Yan, S.F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M.A., Perry, G., Godman, G.C., Nawroth, P., Zweier, J.L., and Stern, D., 1995, Non-enzymatically glycated tau in Alzheimer’s disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide, Nature Med. 1:693–699.
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Perry, G., Smith, M.A. (1998). Neuronal Oxidative Stress is a Common Feature of Alzheimer’s and Parkinson’s Diseases. In: Fisher, A., Hanin, I., Yoshida, M. (eds) Progress in Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5337-3_12
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DOI: https://doi.org/10.1007/978-1-4615-5337-3_12
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