Abstract
Rejection of immunogenic tumors is primarily mediated by T cells with both CD8+ cytolytic T cells (CTL) and CD4+ T helper cells (Th) playing important roles. There is compelling evidence that T cells require at least two signals to become fully activated. Signal one is generated by interaction between an antigen-specific receptor (TCR) on the T lymphocytes and antigenic peptide-MHC complexes on antigen-presenting cells (APC). Signal two is delivered by costimulatory molecules on the APCs to their counterreceptors on the T lymphocytes [1]. In the absence of costimulation, exposure to an antigen can lead to immunological ignorance in vivo [2] or anergy in some T cell clones [3].
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© 1998 Springer Science+Business Media New York
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Chen, L. (1998). Overcoming T Cell Ignorance by Providing Costimulation. In: Walden, P., Trefzer, U., Sterry, W., Farzaneh, F., Zambon, P. (eds) Gene Therapy of Cancer. Advances in Experimental Medicine and Biology, vol 451. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5357-1_26
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DOI: https://doi.org/10.1007/978-1-4615-5357-1_26
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