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Glutamatergic Function in Alzheimer’s Disease

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Neurochemistry

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Abstract

The development of rational, neurotransmitter-based, pharmacological treatments for Alzheimer’s disease (AD) is largely based on substantial cholinergic abnormalities. However, it now appears likely that the neocortical cholinergic deficit in AD can only explain a part of the entire clinical syndrome and that loss of glutamatergic cortical pyramidal neurones is as important.

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Author information

Authors and Affiliations

  1. Dementia Research Laboratory Division of Biochemistry, United Medical and Dental Schools of Guy’s and St Thomas’ Hospitals (UMDS) Guy’s Campus, London, UK

    Paul T. Francis & Sas N. Dijk

Authors
  1. Paul T. Francis
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  2. Sas N. Dijk
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Editor information

Editors and Affiliations

  1. University Hospital, Groningen, The Netherlands

    Albert Teelken  & Jaap Korf  & 

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© 1997 Springer Science+Business Media New York

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Francis, P.T., Dijk, S.N. (1997). Glutamatergic Function in Alzheimer’s Disease. In: Teelken, A., Korf, J. (eds) Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5405-9_25

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  • DOI: https://doi.org/10.1007/978-1-4615-5405-9_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7468-8

  • Online ISBN: 978-1-4615-5405-9

  • eBook Packages: Springer Book Archive

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