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AT1 versus AT2 receptor

  • Chapter
Endocrinology of Cardiovascular Function

Part of the book series: Endocrine Updates ((ENDO,volume 1))

  • 66 Accesses

Abstract

Angiotensin II (AngII) is a circulating and tissue peptide produced by the enzymatic cascade of the renin angiotensin system, which is in charge of regulating blood presure and hydromineral homeostasis. This octapeptide is generated by cleavage of the aminoterminus of the substrate angiotensinogen, a 60 kDa liver protein belonging to the serine protease inhibitor family, by the aspartyl protease renin, produced by the kidney juxtaglomerular apparatus. This enzymatic reaction is the limiting step of the system and produces angiotensin I, an inactive decapeptide which is further processed to Angll by the endothelial angiotensin I converting enzyme. AngII exerts its physiological actions on several tissues, but the main target tissues are the vascular smooth muscle cells in which AngII produces vasoconstriction and glomerular cells of the adrenal cortex, the aldosterone production of which is stimulated by AngII. These actions are mediated by membrane-bound receptors, which were believed to belong to a single class. The development of new pharmacological tools and the cloning techniques have clearly identified 2 classes of receptors, called AT1 and AT2. In this chapter, will be summarized the present knowledge of the structures, the functions, the signaling pathways and physiological involvements of these 2 classes of receptors.

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Authors and Affiliations

  1. INSERM U36, Collège de France, 3 rue d’Ulm, 75005, Paris, France

    Stéphanie Miserey, Sophie Conchon, Charles Parnot, Colette Auzan, Catherine Monnot, Pierre Corvol & Eric Clauser

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  1. Stéphanie Miserey
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  2. Sophie Conchon
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  4. Colette Auzan
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  1. DVA Medical Center and University of California, Irvine, USA

    Ellis R. Levin M.D.

  2. City of Hope Medical Center, Duarte, California, USA

    Jerry L. Nadler M.D.

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Miserey, S. et al. (1998). AT1 versus AT2 receptor. In: Levin, E.R., Nadler, J.L. (eds) Endocrinology of Cardiovascular Function. Endocrine Updates, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5569-8_6

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  • DOI: https://doi.org/10.1007/978-1-4615-5569-8_6

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