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Local Angiotensin II and Tissue Repair Post-Myocardial Infarction

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Angiotensin II Receptor Blockade Physiological and Clinical Implications

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 2))

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Summary

At sites of tissue repair, phenotypically transformed fibroblast-like cells, myofibroblasts, are responsible for fibrous tissue formation. In vivo studies of injured rat cardiac tissues have shown that myofibroblasts (myoFb) express membrane-bound angiotensin-converting enzyme (ACE) and angiotensin (Ang) II receptors. In vitro, these cells have been shown to generate Ang I and II peptides. Locally generated Ang II acts in an autocrine/paracrine manner to regulate myofibroblast collagen turnover in injured tissue.

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Author information

Authors and Affiliations

  1. D. Angiotensin Blockade and Remodeling of Heart in Myocardial Infarction, USA

    Yao Sun

Authors
  1. Yao Sun
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Editor information

Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.) (Distinguished Professor and Director MRC Group in Experimental Cardiology), Peter Zahradka Ph.D. (Associate Professor), Ian M. C. Dixon Ph.D. (Assistant Professor) & Robert E. Beamish M.D. (Professor Emeritus) (Distinguished Professor and Director MRC Group in Experimental Cardiology),  (Associate Professor),  (Assistant Professor) &  (Professor Emeritus)

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© 1998 Springer Science+Business Media New York

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Sun, Y. (1998). Local Angiotensin II and Tissue Repair Post-Myocardial Infarction. In: Dhalla, N.S., Zahradka, P., Dixon, I.M.C., Beamish, R.E. (eds) Angiotensin II Receptor Blockade Physiological and Clinical Implications. Progress in Experimental Cardiology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5743-2_34

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  • DOI: https://doi.org/10.1007/978-1-4615-5743-2_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7631-6

  • Online ISBN: 978-1-4615-5743-2

  • eBook Packages: Springer Book Archive

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