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From Genes to Functional Gene Products during Ageing

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Molecular Gerontology

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Abstract

For the survial of any living system it is crucial that its homeostatic processes function accurately and efficiently. Homeostatic balance in the cell is attained through a molecular network of repair and maintenance processes. Although the genomic information for these processes is encoded in the DNA, this information becomes functionally meaningful only when it is accurately transcribed and translated into gene products. Whereas two types of RNA, transfer (t) RNA and ribosomal (r) RNA, are themselves functional molecules, the genetic information transcribed into the third RNA, messenger (m) RNA, has to be generally trans1ated from a language of nucleic acids into a language of amino acids in order to produce proteins which are the functional gene products. Since we consider ageing as the progressive accumulation of damage due to a failure of maintenance mechanisms1, we think that it is important that the formation, functioning and turnover of the primary molecules constituting the maintenance network are studied with respect to ageing.

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Authors and Affiliations

  1. Laboratory of Cellular Ageing Department of Molecular and Structural Biology, University of Aarhus, DK-8000, Aarhus-C, Denmark

    Lise Brock Andersen, Ann Lund, Marie Kveiborg, Brian F. C. Clark & Suresh I. S. Rattan

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  1. Lise Brock Andersen
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  2. Ann Lund
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  3. Marie Kveiborg
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  1. University of Aarhus, Aarhus, Denmark

    Suresh I. S. Rattan

  2. The University of Namur, Namur, Belgium

    Olivier Toussaint

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Andersen, L.B., Lund, A., Kveiborg, M., Clark, B.F.C., Rattan, S.I.S. (1996). From Genes to Functional Gene Products during Ageing. In: Rattan, S.I.S., Toussaint, O. (eds) Molecular Gerontology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5889-7_5

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