Abstract
Aged humans, and other mammals, exhibit a variety of bio-behavioral changes ranging from decreases in muscle tone and motor coordination to impairments of sensory and cognitive abilities. Among the earliest, most consistent, and potentially most devasting of these changes are deficits in memory and related cognitive functions.
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References
Anderson, O. W., 1981, The social strategy of disease control: the case of senile dementia, in: “Clinical Aspects of Alzheimer’s Disease and Senile Dementia,” N. E. Miller and G. D. Cohen, eds., Raven Press, NY.
Bartus, R. T., Flicker, C., Dean, R. L., Fisher, S., Pontecorvo, M. and Figueiredo, J., 1986, Behavioral and biochemical effects of nucleus basalis magnocellularis lesions: implications and possible relevance to understanding or treating Alzheimer’s disease, in: “Progress in Brain Research,” Vol 70, E. Fliers, ed., Elsevier, NY.
Bartus, R. T., Pontecorvo, M. J., Flicker, C., Dean, R. L. and Figueiredo, J. C., 1986, Behavioral recovery following bilateral lesions of the nucleus basalis does not occur spontaneously, Pharmacol Biochem & Behay., 24: 1287–1292.
Bartus, R. T., 1986, Drugs to treat age-related cognitive disorders: on the threshold of a new era in the pharmaceutical industry? in: “Treatment Development Strategies for Alzheimer’s Disease,” T. Crook, R. T. Bartus, S. Ferris, and S. Gershon, eds., Powley Assoc. Inc., Madison, CT.
Bartus, R. T. and Dean, R. L., 1985, Developing and utilizing animal models in the search for an effective treatment for age-related memory disturbances, in: “Physiological Aging and Dementia,” C. Gottfries, ed., Karger Press, Basle.
Bartus, R. T., Flicker, C., Dean, R. L., Pontecorvo, M. J., Figueiredo, J. and Fisher, S. K., 1985, Selective memory loss following nucleus basalis lesions: long term behavioral recovery despite persistent cholinergic deficiencies, Pharmacol Biochem Behay., 23: 125–135.
Bartus, R. T., Dean, R. L. and Beer, B., 1983, An evaluation of drugs for improving memory in aged monkeys: implications for clinical trials in humans, Psychopharmacol Bull., 19: 168–184.
Bartus, R. T., Flicker, C. and Dean, R. L., 1983, Logical principles for the development of animal models of age-related memory impairments, in: “Assessment for Geriatric Psychopharmacology,” T. Crook, S. Ferris, and R. T. Bartus, eds., Mark Powley Assoc. Inc., Canaan, CT.
Bartus, R.T., Dean, R. L., Beer, B. and Lippa, A. S., 1982, The cholinergic hypothesis of geriatric memory dysfunction, Science 217: 408–417.
Bartus, R. T., 1982, The one-trial passive avoidance procedure as a possible marker of aging, in: “Biological Markers of Aging,” M.E. Reff and E.L. Schneider, eds., Bartus, R. T.. 82–2221, ( April).
Bartus, R. T., 1979, Effects of aging on visual memory, sensory processing and discrimination learning in the non-human primate, in: “Aging, Vol 10: Sensory Systems and Communication in the Elderly,” J. M. Ordy, and K. Brizzee, eds., Raven Press, NY.
Cowell, D. D., 1983, Senile dementia of the Alzheimer’s type: a costly problem, J Geriatrics Soc., 31: 61.
Crapper, D. R. and Dalton, A. J., 1973, Aluminum induced neurofibrillary degeneration, brain electrical activity and alteration in acquisition and retention, Physiol Behay., 10: 935–945.
Crapper, D. R. and Dalton, A. J., 1972, Alterations in short-term retention, conditioned avoidance response acquisition and motivation following aluminum induced neurofibrillary degeneration, Physiol Behay., 10: 925–932.
Crook, T., Bartus, R. T., Ferris, S., Whitehouse, P., Cohen, G. D., and Gershon, S., 1986, Age-associated memory impairment: proposed diagnostic criteria and measures of clinical change, Develop Neuropsychol. (in press)
Davis, K. L., Mohs, R. C., Davis, B. M., Levy, M. I., Horvath, T. B., Ronsberg, G. S., Ross, A., Rothpearl, A. and Rosen, W., 1982, Cholinergic treatment in Alzheimer’s disease: implications for future research, in: “Aging, Vol 19: Alzheimer’s Disease, A Report of Progress in Research,” S. Corkin, K. L. Davis, J. H. Growdon, E. Usdin, and R. J. Wurtman, eds., Plenum Press, NY.
Davis, R. T., 1978, Old monkey behavior, Exp Gerontol., 13: 237–250.
Dean, R. L. and Bartus, R. T., 1986, Behavioral models of aging in nonhuman primates, in: “Handbook of Psychopharmacology, Vol 20: Psychopharmacology of the Aging Nervous System,” L. L. Iverson, S. D. Iversen, and S. H. Synder, eds., Plenum Press, NY. (in press)
Dunnett, S. B., 1985, Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats, Psychopharmacology (Berlin) 87: 357–363.
Finger, S. and Stein, D. G., 1982, “Brain Damage and Recovery: Research and Clinical Perspectives, Academic Press, NY.
Flicker, C., Dean, R., Bartus, R. T. and Fisher, S. H., 1985, Animal and human memory dysfunctions associated with aging, cholinergic lesions, and senile dementia, in: “Memory Dysfunctions: An Integration of Animal and Human Research from Preclinical and Clinical Perspectives,” D. S. Olton, E. Gamzu, and S. Corkin, eds., Ann NY Acad Sci., Vol 444.
Flicker, C., Bartus, R. T., Crook, T. H. and Ferris, S. H., 1984, Effects of aging and dementia upon recent visuospatial memory, Neurobiol Aging. 5: 275–283.
Goldsmith, M. F., 1984, Youngest institute addresses aging problems, J Amer Med Assoc., 252: 2315–2317.
Gwyther, L. P. and Blazer, D. G., 1984, Family therapy and the dementia patient, Amer Family Physician. 29: 149–156.
Hepler, D. J., Wenk, G. L., Cribbs, B. L., Olton, D. S. and Coyle, J. T., 1985, Memory impairments following basal forebrain lesions. Brain Res., 346: 8–14.
Johnston, M. V., McKinney, M. and Coyle, J. T., 1979, Evidence for a cholinergic projection from neurons in basal forebrain. Proc Nat’l Acad Sci., USA 76: 5392–5396.
Klatzo, I., Wisniewski H. and Streicher, E., 1965, Experimental production of neurofibrillary degeneration. J Neuropath Exp Neurol., 24: 187–199.
Kordower, J. H. and Gash, D. M., 1986, Animals and experimentation: an evaluation of animal models of Alzheimer’s and Parkinson’s disease, Integr Psychiatry. 4: 64–80.
Kral, V. A,. 1978, Benign senescent forgetfulness, in: “Alzheimer’s disease: Senile Dementia and Related Disorders,” R Kataman, R. D. Terry, and K. L. Bick, eds., Raven Press, NY.
Kubanis, P., Gobbel, G. and Zornetzer, S. F., 1981, Age-related memory deficits in Swiss mice, Behav Neural Biol., 32: 241–247.
Lashley, K. S., 1929, “Brain Mechanisms and Intelligence: A Quantitative Study of Injuries to the Brain,” University of Chicago Press, Chicago, IL.
LeVere, T. E., 1980, Recovery of function after brain damage: a theory of the behavioral deficit, Physiol Psychol., 8: 297–308.
Mishkin, M., Aigner, T. G. and Aggleton, J., 1985, Neurobiology of memory in primate brain, Thirteenth International Congress of Gerontology Abstracts.
Mufson, E. J. and Stein, D. G., 1980, Behavioral and morphological aspects of aging: an analysis of rat frontal cortex, in: “The Psychobiology of Aging: Problems and Perspectives,” D. G7 Stein, ed., Elsevier, NY.
Murray, C. L. and Fibiger, H. D., 1985, Learning and memory deficits after lesions of the nucleus basalis magnocellularis: reversal by physostigmine, Neurosci., 14: 1025–1032.
Office of Technology Assessment, United States Congress, 1985, Technology and Aging in America, Washington, DC.
Olton, D. S., 1985, Strategies for the development of animal models of human memory impairments, in: “Memory Dysfunctions: An Integration of Animal and Human Research from Preclinical and Clinical Perspectives,” D. S. Olton, E. Gamzu, and S. Corkin, eds., Ann NY Acad Sci., Vol 444.
Oscar-Berman, M., Bonner, R. T., 1985, Matching-and delayed matching-to-sample performance as measures of visual processing, selective attention, and memory in aging and alcoholic individuals, Neuropsycholoqia. 23 (5): 639–651.
Reisberg, B., Ferris, S. H. and Crook, T., 1982, Signs, symptoms and course of age-associated cognitive decline, in: “Alzheimer’s Disease: A Report of Progress in Research,” S. Corkin, K. L. Davis, J. H. Growdon, E. Usdin, and R. J. Wurtman, eds., Raven Press, NY.
Ridley, R. M., Murray, T. K., Johnson, J. A. and Baker, H. F., 1986, Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: modification by cholinergic drugs, Brain Res., 376: 108–116.
Ridley, R. M., Baker, H. F., Drewett, B. and Johnson, J. A., 1985, Effects of ibotenic acid lesions of the basal forebrain on serial reversal learning in marmosets, Psychopharmacology (Berlin). 86: 438–443.
Rogers, J. D., Brogan, D. and Mirra, S. S., 1985, The nucleus basalis of Meynert in neurological disease: a quantitative morphological study, Ann Neurol., 17: 163–170.
Stein, D. G. and Firl, A. C., 1976, Brain damage and reorganization of function in old age, Exp Neurol., 52: 157–167.
U.S. Department of Health and Human Services, 1984, Alzheimer’s Disease: Report of the Secretary’s Task Force on Alzheimer’s Disease. (DHHS Publication No. [ADMI84–1323. US Government Printing Office, Washington, DC.
Weinberg, J., 1980, Geriatric psychiatry, in: “Comprehensive Textbook of Psychiatry/III,” (3rd ed., Vol. III), H. I. Kaplan, A. M. Freedman, and B. J. Sadock, eds., Williams & Williams, Baltimore, MD.
Whitehouse, P. L., Price, D. L., Struble, R. G., Clark, A. W., Coyle, J. T. and DeLong, M. R., 1982, Alzheimer’s disease and senile dementia: Loss of neurons in basal forebrain, Science. 215: 1237–1239.
Whitehouse, P. J., Price, D. L., Clark, A. W., Coyle, J. T. and DeLong, M. R., 1981, Alzheimer’s disease: evidence for selective loss of cholinergic neurons in the nucleus basalis, Ann Neurol., 10: 122–126.
Wisniewski, H. M., Bruce, M. E. and Fraser, H., 1975, Infection etiology of neuritic (senile) plaques in mice, Science. 190: 1108–111.
Zelinsky, D., 1986, Complaints of memory loss in community dwelling elderly, in: “The Handbook of Clinical Memory Assessment in Older Adults,” L. Poon, ed., American Psychological Assoc., Washington, DC. (in press)
Zornetzer, S. F., 1985, Catecholamine system involvement in age-related memory dysfunction, in: “Memory Dysfunctions: An Integration of Animal and Human Research from Preclinical and Clinical Perspectives,” Vol 444, D. S. Olton, E. Gamzu, and S. Corkin, eds., Ann NY Acad Sci.
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Bartus, R.T., Dean, R.L. (1987). On Possible Relationships between Alzheimer’s Disease, Age-Related Memory Loss and the Development of Animal Models. In: Altman, H.J. (eds) Alzheimer’s Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6414-0_11
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