Abstract
Vitamins are organic chemical substances that the body requires for its metabolism and cannot synthesize for itself. They are therefore needed in the diet. Deficiency may cause physical, mental, and behavioral effects. Vitamins are traditionally divided into fat-soluble and water-soluble, and it is probably true that psychological abnormalities encountered in clinical practice are more often associated with deficiences of water-soluble vitamins than with deficiencies of fat-soluble vitamins. Some substances are grouped as vitamins, but deficiency of these apparently does not occur spontaneously. These substances will be considered separately.
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Adams, P. W., Wynn, V., Rose, D. P., Seed, M., Folkard, J., and Strong, R., 1973, Effects of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraception. Lancet 2:867–904.
Ahmed, M., 1972, Neurological disease and folate deficiency, Br. Med. J. 1:181.
Arakawa T., 1970, Congenital defects in folate utilization. Am. J. Med. 48:594–598.
Arakawa, T., Narisawa, K., Tanno, K., Ohara, K., Higashi, O., Honda, Y., Tamura, T., Wada, Y., Mizuno, T., Hayashi, T., Hirooka, Y., Ohno, T., and Ikeda, M., 1967, Megaloblastic anemia and mental retardation associated with hyper-folic-acidaemia probably due to N5 methyl-tetrahydrofolate transferase deficiency, Tohoku J. Exp. Med. 93:1–22.
Bachrach, S., Fisher, J., and Parks, J. S., 1979, An outbreak of vitamin D deficiency rickets in a susceptible population. Pediatrics 64:871–877.
Barnes, M., 1978, Detection and incidence of B and C vitamin deficiency in alcohol-related illness, Ann. Clin. Biochem. 15:307–312.
Batata, M., Spray, G. H., Bolton, F. G., Higgins, G., and Wollner, L., 1967, Blood and bone marrow changes in elderly patients with special reference to folic acid, vitamin B12, iron and ascorbic acid, Br. Med. J. 2:667–669.
Bayoumi, R. A., and Rosalki, S. B., 1976, Evaluation of methods of co-enzyme activation of erythrocyte enzymes for detection of deficiency of vitamins B1, B2 and B6, Clin. Chem. 22:327–335.
Beattie, A. D., and Sherlock, S., 1976, Ascorbic acid deficiency in liver disease. Gut 17:571–575.
Beeson, P. B., and McDermott, W., 1975, Text Book of Medicine, Sanders and Co., London, 1368 pp.
Blackstock, E. E., Gath, D. H., Gray, R. C., and Higgins, G., 1972, The role of thiamine deficiency in the aetiology of hallucinatory states complicating alcoholism, Br. J. Psychiatry 121:356–364.
Blass, J. P., and Gibson, G. E., 1977, Abnormality of a thiamine requiring enzyme in patients with Wernicke-Korsakoff syndrome, N. Engl. J. Med. 297:1367–1370.
Bonjour, J. P., 1980a, Vitamin and alcoholism. III. Vitamin Be, Int. J. Vitam. Nutr. Res. 30:215–230.
Bonjour, J. P., 1980b, Vitamins and alcoholism. V. Riboflavin, Int. J. Vitam. Nutr. Res. 50:425–430.
Botez, M. T., Cadotte, M., Beaulieu, R., Pichette, L. P., and Pison, C., 1976, Neurological disorders responsive to foHc acid therapy.Can. Med. Assoc. J. 115:217–223.
Cameron, W. M., 1978, Isoniazid overdose. Can. Med. Assoc. J. 118:1413–1415.
Carney, M. W. P., 1967, Serum folate values in 423 psychiatric patients, Br. Med. J. 4:512–516.
Carney, M. W. P., 1970, Serum vitamin B12 values in psychiatric inpatients, Dis. Nerv. Syst. 31:566–569.
Carney, M. W. P., 1971, Beri-beri in Blackpool Br. Med. J. 2:109–110.
Carney, M. W. P., 1979, Psychiatric aspects of folate deficiency, in: Folic Acid in Neurolgy, Psychiatry and Internal Medicine (M. T. Botez and E. H. Reynolds, eds.), pp. 475–582, Raven Press, New York.
Carney, M. W. P., and Brozowic, M., 1978, Self-inflicted bleeding and bruising. Lancet 1:924–925.
Carney, M. W. P., and Sheffield, B. F., 1970, Associations of subnormal serum folate and vitamin B12 and effects of replacement therapy, J. Nerv. Ment. Dis. 150:404–412.
Carney, M. W. P., and Sheffield, B. F., 1978, Serum folic acid and B12 in 272 psychiatric inpatients, Psychol. Med. 8:139–144.
Carney, M. W. P., Williams, D. G., and Sheffield, B. F., 1979, Thiamine and pyridoxine lack in newly-admitted psychiatric patients, Br. J. Psychiatry 135:249–254.
Carney, M. W. P., Ravindran, A., Rinsler, M., and Williams, D. G., 1982, Thiamine, riboflavin and pyridoxine deficiency in psychiatric in-patients, Br. J. Psychiatry 141:271–272.
Chanarin, I., 1973, New light on pernicious anaemia, Lancet 2:538–539.
Chanarin, I., Perry, J., and Reynolds, E. H., 1974, Transport of folate into cerebrospinal fluid in man, Clin. Sei. Mol. Med. 46:369–373.
Committee on Nutrition, American Academy of Pediatrics, 1976, Megavitamin therapy for childhood psychoses and learning disabilities. Pediatrics, 58:910–912.
Cott, A., 1971, Orthomolecular approach to the treatment of learning disabilities, Schizophr. Bull. 395:105.
Davis, R. E., and Smith, B. K., 1974, Pyridoxal and folate deficiency in alcoholics, Med. J. Austr. 2:357–560.
Delaney, R. L., Lankford, M. G., and Sullivan, J. F., 1966, Thiamine, and plasma magnesium lactate abnormalities in alcohohc patients, Proc. Soc. Exp. Biol. Med. 123:675–679.
Derot, M., Castaigne, P., Morel-Maroger, A., and Leclerq, A., 1967, Syndrome neurologique nutritionel complexe reversible par administration d’acide foHque, Bull. Mem. Soc. Med. Paris 118:867–874.
Editorial, 1977, Liver disease and vitamin C, Br. Med. J. 1:735–736.
Edwin, E., Holten, K., Norman, K. R., Schrumpf, A., and Skaag, O. E., 1965, Vitamin B,2 hypovitaminoses in mental diseases, Acta. Psychiatr. Scand. 45:19–36.
Elsborg, L., Hansen, T., and Rafaelson, O. J., 1979, Vitamin B12 concentrations in psychiatric patients. Acta Psychiatr. Scand. 59:145–152.
Feldman, M. H., and Schlezinger, N. S., 1970, Benign intracranial hypertension associated with hypervitaminosis A, Arch. Neurol. 22:1–7.
Fennelly, J., Frank, O., Baker, H., and Leery, C. M., 1964, Peripheral neuropathy of the alcoholic: I. Aetiological role of aneurin and other B-complex vitamins, Br. Med. J. 2:1290–1292.
Foulks, E., and Katz, S. H. 1977, in: Malnutrition, Behaviour and Social Organisation, p. 224, Academic Press, London.
Frenkel, E. P., McCall, M. S., and Sheehon, R. G., 1973, Cerebro-spinal fluid folate and vitamin B12 in anti-convulsant induced megaloblastosis, J. Lab. Clin. Med. 81:105–115.
Ghadirian, A. M., Anouth, J., and Engelsmann, F., 1980, Folate deficiency and depression, Psychosomatics 21:926–929.
Grant, H. C., Hoffbrand, A. V., and Wills, D. G., 1965, Folate deficiency and neurological disease. Lancet 2:763–767.
Hallstrom, T., 1969, Serum B12 and folate concentrations in mental patients. Acta Psychiatr. Scand. 45:19–36.
Herbert, V., 1962, Experimental nutritional folate deficiency in man.Trans. Assoc. Am. Physicians 75:307–320.
Herbert, V., Gottlieb, C. W., and Altschule, M. D., 1965, Apparent low B12 levels associated with chlorpromazine. Lancet 2:738.
Hoorn, R. K., Flikweert, J. P., and Westernink, 1975, Vitamin B1, B2 and B6 deficiencies in geriatric patients measured by co-enzyme stimulation of enzyme activities, Clin. Chim. Acta 61:151–162.
Hunter, R., and Matthews, D. M., 1965, Mental symptoms in vitamin B12 deficiency. Lancet 2:738.
Hunter, R., Jones, M., Jones, T. G., and Matthews, D. M., 1967, Serum B12 and folate concentration in mental patients, Br. J. Psychiatry 113:1291–1295.
Ishii, N., and Nishikara, Y., 1981, Pellagra among chronic alcoholics: Clinical and pathological study of 20 necropsy cases, J. Neurol. Neurosurg. Psychiatry 44:209–215.
Joiner, C. L., McArdle, B., and Thompson, R. H. J., 1950, Blood pyruvate estimations in the diagnosis and treatment of polyneuritis, Brain 73(29):431–452.
Joliffe, N., Bowman, K. N., Rosenblum, L. A., and Fein, H. D., 1960, Nictonic acid deficiency encephalopathy, JAMA 114:307–320.
Kallstrom, B., and Nylof, R., 1969, Vitamin B12 and folic acid in psychiatric patients. Acta Psychiatr. Scand. 45:137–152.
Kershaw, P. W., 1967, Blood thiamine levels in alcoholism and confusional states, Br. J. Psychiatry 113:387–393.
King, C. E., 1977, Vitamin D, alcoholism and dialysis, Ann. Intern. Med. 86:830.
Kinsman, R. A., and Hood, J., 1971, Some behavioral effects of ascorbic acid deficiency.Am. J. Clin. Nutr. 24:455–464.
Krippner, S., and Fisher, S. A., 1973, A study of neurological procedures and megavitamin treatment for children with brain dysfunction, Orthomolecular Psychiatry 1:121–132.
Lanzkowsky, P., 1970, Congenital malabsorption of folate. Am. J. Med. 48:580–583.
Livingston, J. E., Moreland, P. M., and Applegarth, D. A., 1978, Vitamin Be status in women with post partum depression, Am. J. Clin. Nutr. 31:886–891.
Lonsdale, D., and Shamburger, R. J., 1980, Red cell transketolase as an indicator of nutritional deficiency. Am. J. Clin. Nutr. 33:205–211.
Lopez, C., Schwartz, J. V., and Cooperman, J. M., 1980, Riboflavin deficiency in an adolescent population in New York City, Am. J. Clin. Nutr. 33:1283–1286.
Luhby, A. L., Eagle, F. J., Roth, E., and Copperman, J. M., 1961, Relapsing megaloblastic anemia in an infant due to a specific defect in gastrointestinal absorption of folic acid, Am. J. Dis. Child. 102:482–483.
Lumeng, L., and Li, T. R., 1974, Vitamin Be metabolism in chronic alcohol abuse: Pyridoxal phosphate levels in plasma and the effects of acetaldehyde in pyridoxal phosphate synthesis and degradation in human erythrocytes, J. Clin. Invest. 53:693–704.
Manzoor, M., and Runcie, J., 1976, Folate responsive neuropathy—report of 10 cases,Br. Med. J. 1:1176–1178.
Mattson, R. M., Gallagher, B. B., Reynolds E. H., and Glass, D., 1973, Folate therapy in epilepsy. Arch. Neurol. 29:78–81.
McLaren, D. S., Docherty, M. A., and Boyd, D. H. A., 1980, Assessment of thiamine status of patients with an alcohol problem, Nutr. Soc., Abstracts of Communications 39:241.
Minot, G. R., and Murphy, W. P., 1926, Treatment of pernicious anemia by a special diet, J. Am. Med. Assoc. 87:470–476.
Moran, J. R., and Greene, H. L., 1979, The B vitamins and vitamin C in human nutrition. Am. J. Dis. Child 133:308–314.
Neubauer, H., 1970, Mental deterioration in epilepsy due to folate deficiency, Br. Med. J. 2:759–761.
Nobbs, B. T., 1974, Pyridoxal phosphate status in clinical depression. Lancet 1:405–406.
Oliver, T. K., 1958, Chronic vitamin A intoxication. Am. J. Dis. Child. 95:57–67.
Perry, J., Lumb, M., Laundy, M., Reynolds, E. H., and Chanarin, I., 1976, Role of vitamin B6 in folate co-enzyme synthesis, Br. J. Haematol. 32:263–268.
Persson, B., Tunell, R., and Ekengren, K., 1965, Chronic vitamin A intoxication during the first half year of life. Acta Paediatr. Scand. 54:49–60.
Phillips, R. B., Victor, M., Adams, R. D., and Davidson, C. S., 1952, A study of the nutritional defect in Wernicke’s syndrome, J. Clin. Investig. 31:859.
Pincus, J. H., Reynolds, E. H., and Glazer, G. H., 1972, Subacute combined system degeneration with folate deficiency, J. Am. Med. Assoc. 221:496–497.
Read, A. E., Gough, K. R., Pardoe, J. L., and Nicholas, A., 1965, Nutritional studies on the entrants to an old peoples home with particular reference to folic acid deficiency, Br. Med. J. 2:843–848.
Reilly, T. M., 1979, The value of thiamine replacement in chronic alcoholism: A reminder, Br. J. Addict. 74:205–207.
Reinker, L., Hohenauer, L., and Ziegler, E. E., 1972, Activity of red blood cell glutamic oxalacetic transaminase in epileptic children under antiepileptic treatment, Clin. Chim. Acta 36:270–211.
Reynolds, E. H., 1967, Schizophrenia like psychoses of epilepsy and disturbances of folate and vitamin B12 metabolism induced by anti-convulsant drugs,Br. J. Psychiatry 113:911–919.
Reynolds, E. H., 1976, The neurology of vitamin B12 deficiency: Metabolic mechanisms.Lancet 2:832–833.
Reynolds, E. H., Pierce, J. M., Bailey, J., Coppen, A., 1970, Folate deficiency in depressive illness, Br. J. Psychiatry 117:287–292.
Reynolds, E. H., Rothfeld, P., and Pincus, J., 1973, Neurological disease associated with folate deficiency, Br. Med. J. 2:398–400.
Rickes, E. L., Brink, N. G., Koniuszy, F. R., Wood, T. R., and Folkes, K., 1948, Crystalline vitamin B12, Science 107:396–397.
Riding, J., 1975, Wet beri-beri in an alcoholic, Br. Med. J. 3:79.
Rivkin, R. S., 1979, Hormones, drugs and riboflavin, Nutr. Rev. 37:241–245.
Rose, M., and Johnson, I., 1978, Reinterpretation of the haematological effects of anti-convulsant treatment. Lancet 1:1349–1350.
Rubin, E., Florman, A. L., and Degman, T., 1970, Hepatic injury in chronic hypervitaminosis A, Am. J. Dis. Child 119:132–136.
Santiago-Borrero, P. J., Santini, R., Perez-Santiago, E., Maldano, N., Millan, S., and Coll-Camalez, G., 1973, Congenital isolated defect of folic acid absorption, J. Pediatr. 82:450–455.
Schwartz, R. A., Gross, M., Lonsdale, D., and Shamburger, R., 1979, Transketolase activity in psychiatric patients, J. Clin. Psychiatry 40:427–429.
Shane, B., and Contractor, S. F., 1975, Assessment of vitamin Be status: Studies on pregnant women and oral contraceptive users. Am. J. Clin. Nutr. 28:739–747.
Shaw, D. M., McSweeney, D. A., Johnson, A. L., O’Keefe, R., Naidoo, D., Macleod, D. M., Jog, S., Preece, J. M., and Crowley, J. M., 1971, Folate and amine metabolites in senile dementia: A combined trial and biochemical study, Psychol. Med. 1:166–171.
Shaywitz, B. A., Siegel, N. J., and Benson, H. A., 1977, Megavitamins for minimal brain dsy-function, J. Am. Med. Assoc. 238:1749–1750; Medical Letter, May 22, 1980.
Shorvon, S. D., Carney, M. W. P., Chanarin, I., and Reynolds, E. H., 1980, The neuropsychiatry of megoloblastic anaemia, Br. Med. J. 281:1036–1043.
Shulman, R., 1967a, Psychiatric aspects of pernicious anaemia: A prospective controlled investigation, Br. Med. J. 3:266–270.
Shulman R., 1967b, A survey of vitamin B12 deficiency and psychiatric illness in an elderly psychiatric population, Br. J. Psychiatry 113:241–251.
Shulman, R., 1972, The present status of vitamin B12 and folic acid deficiency in psychiatric illness. Can. Psychiatr. Assoc. J. 19:205–216.
Shulman, R., 1979, An overview of folic acid deficiency and psychiatric illness, in: Folic Acid in Neurology, Psychiatry, and Internal Medicine (M. I. Botez and E. H. Reynolds, eds.), pp. 463–474, Raven Press, New York.
Smith, E. L., and Parker, L. F. J., 1948, Purification of anti-pernicious anemia factor,Biochem. J. 43:viii (abstract).
Sneath, P., Chanarin, I., Hodkinson, M. H., McPherson, C. K., and Reynolds, E. H., 1973, Folate status in a geriatric population and its relation to dementia. Age Ageing 2:177–182.
Spaans, F., 1970, No effect of folic acid supplement on folate and serum vitamin B12 in patients on anticonvulsants. Epilepsia 11:403–411.
Spivak, J., and Jackson, D. L., 1977, Pellagra: An analysis of 18 patients and a review of the literature, Johns Hopkins Med. J. 140:295–309.
Springer, N. S., 1979, Ascorbic acid status of children with developmental distribution, J. Am. Diet. Assoc. 75:425–428.
Stafne, W. A., and Moe, A. E., 1951, Hypoprothrombinemia due to dicoumarol in a maUngerer: A case report, Ann. Intern. Med. 35:910–911.
Stone, W. J., Warnock, L. G., and Wagner, C., 1975, Vitamin Be deficiency in uremia. Am. J. Clin. Nutr. 128:950–957.
Strachau, R. W., and Henderson, J. G., 1967, Dementia and folate deficiency, Q. J. Med. 36:189–204.
Taurot, G. P., Danks, D. M., Rowe, P. B., Van Der Weyden, M. G., Schwartz, M. A., Collins, V. L., and Neal, B. W., 1976, Dihydrofolate reductase deficiency causing megaloblastic anemia in two families, N. Engl. J. Med. 294:466–470.
Thornton, W. E., and Thornton, B. P., 1978, Folic acid, mental function, and dietary habits, J. Clin. Psychiatry April:315–322.
Velentzas, C., Oreopoulos, D. G., Brandes, L., Wilson, D. R., and Marquez-Julio, A., 1977, Abnormal vitamin D levels, Ann. Intern. Med. 86:198.
Victor, M., Adams, R. D., and CoHins, G. H., 1971, The Wernicke-Korsakoff Syndrome, Blackwell, Oxford.
Walker, A., 1968, Chronic scurvy, Br. J. Dermatol. 80:625–630.
Word, B., Gysbert, A., Grode, A., Davis, S., Mulholland, J., and Breen, K., 1980, A study of partial thiamine restriction in human volunteers. Am. J. Clin. Nutr. 33:848–861.
Ziegler, D. K., 1978, Toxicity to the nervous system of diphenylhydantoin: A review, Int. J. Neurol. 11:383–400.
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Carney, M.W.P. (1984). Vitamin Deficiencies and Excesses: Behavioral Consequences in Adults. In: Galler, J.R. (eds) Nutrition and Behavior. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7219-0_7
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