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Immunization Against Erythrocytic Forms of Malaria Parasites

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Immunity to Blood Parasites of Animals and Man

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 93))

Abstract

It is almost 20 years since a worldwide program of malaria eradication was formally adopted by the 8th World Health Assembly and its implementation coordinated by the World Health Organization (WHO). The strategy of eradication involved widespread indoor spraying with residual insecticides and elimination of remaining foci using antimalarial drugs and further spraying. The success of this international endeavor can be judged from a recent WHO report showing that malaria has been eradicated or controlled in almost 80% of originally malarious zones.* However, the remaining areas where eradication could not be implemented include 66 countries covering vast tracts of the developing world, notably in Africa, inhabited by about 500 million people. Reliable data are not available from these areas, but it seems likely that malaria at present produces a morbidity rate of 100 million and mortality of about 1 million per annum, mainly among young children. Moreover, the resurgence of malaria in Pakistan, Bangladesh, Sri Lanka, and several Indian provinces that all had advanced eradication programs is a source of much alarm. It is clear that tropical areas still harbor a vast reservoir of malarial infection and that its eradication or even containment is no longer feasible with available health facilities.

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Bibliography

  • Bannister, L.H., Butcher, G.A., Dennis, E.D. & Mitchell, G.H. 1975. Structure and invasive behaviour of Plasmodium knowlesi merozoites in vitro. Parasitology 71: 483–491.

    Article  CAS  Google Scholar 

  • Bazaz-Malik, G. 1973. Increased resistance to malaria after Mycobacterium tuberculosis infection. Indian J. Med. Res. 61: 1014–1024.

    PubMed  CAS  Google Scholar 

  • Brown, I.N. 1969. Immunological aspects of malaria infection. Adv. Immunol. 11: 267–349.

    Article  PubMed  CAS  Google Scholar 

  • Brown, I.N., Allison, A.C. & Taylor, R.B. 1968. Plasmodium berghei infections in thymectomized rats. Nature (Lond.) 219: 292–293.

    Article  CAS  Google Scholar 

  • Brown, K.N. 1971. Protective immunity to malaria provides a model for the survival of cells in an immunologically hostile environment. Nature (Lond.) 230: 163–167.

    Article  Google Scholar 

  • Brown, K.N. 1973. Antibody induced variation in malaria parasites. Nature (Lond.) 242: 49–50.

    Article  CAS  Google Scholar 

  • Brown, K.N. 1974. Antigenic variation and immunity to malaria. In Parasites in the Immunized Host: Mechanisms of Survival. Porter, R. & Knight, J., Eds.: 35–51. Ciba Foundation Symposium 25 (new series). Associated Scientific Publishers. Amsterdam, The Netherlands.

    Google Scholar 

  • Brown, K.N. & Brown, I.N. 1965. Immunity to malaria: antigenic variation in chronic infections by Plasmodium knowlesi. Nature (Lond.) 208: 1286–1288.

    Article  CAS  Google Scholar 

  • Brown, K.N., Brown, I.N., Trigg, P.I., Phillips, R.S. & Hills, L.A. 1970. Immunity to malaria. II. Serological response of monkeys sensitized by drug-suppressed infection or by dead parasitized cells in Freund’s complete adjuvant. Exp. Parasitol. 28: 318–338.

    Article  PubMed  CAS  Google Scholar 

  • Brown, K.N. & Hills, L.A. 1974. Antigenic variation and immunity to Plasmodium knowlesi: antibodies which induce antigenic variation and antibodies which destroy parasites. Trans. R. Soc. Trop. Med. Hyg. 68: 139–142.

    Article  PubMed  CAS  Google Scholar 

  • Butcher, G.A. 1975. Unpublished observations.

    Google Scholar 

  • Butcher, G.A. & Cohen, S. 1972. Antigenic variation and protective immunity in Plasmodium knowlesi malaria. Immunology 23: 503–521.

    PubMed  CAS  Google Scholar 

  • Butcher, G.A., Mitchell, G.H. & Cohen, S. 1973. Letter: Mechanism of host specificity in malarial infection. Nature (Lond.) 244: 40–41.

    Article  CAS  Google Scholar 

  • Coggeshall, L.T. & Kumm, H.W. 1938. Effect of repeated superinfection upon potency of immune serum of monkeys harboring chronic infections of Plasmodium knowlesi. J. Exp. Med. 68: 17–27.

    Article  CAS  Google Scholar 

  • Cohen, S. 1975, Immunalprophylaxis of protozoal diseases. In Clinical Aspects of Immunology, 3rd edit. Gell, P.G.A., Coombs, R.R.A. & Lachman, P.J., Eds.: 1649–1680. Blackwell Scientific Publishing Company. Oxford, England.

    Google Scholar 

  • Cohen, S. & Butcher, G.A. 1970. Properties of protective malarial antibody. Immunology 19: 369–383.

    PubMed  CAS  Google Scholar 

  • Cohen, S. & Butcher, G.A. 1972. The immunologic response to Plasmodium. Am. J. Trop. Med. Hyg. 21: 713–721.

    PubMed  CAS  Google Scholar 

  • Cohen, S., Butcher, G.A & Crandall, R.B. 1969. Action of malarial antibody in vitro. Nature (Lond.) 223:. 368–371.

    Article  CAS  Google Scholar 

  • Cohen, S., Butcher, G.A. & Mitchell, G.H. 1972. In vitro studies of malarial antibody. Proc. Helminthol. Soc. Wash. 39: 231–237.

    Google Scholar 

  • Cohen, S., McGregor, I.A. & Carrington, S.P. 1961. Gamma-globulin and acquired immunity to human malaria. Nature (Lond.) 192: 733–737.

    Article  CAS  Google Scholar 

  • Coleman, R.M., Rencricca, N.J., Stout, J.P., Brissette, W.H. & Smith D.M. 1975. Splenic mediated erythrocyte cytotoxicity in malaria. Immunology 29: 49–54.

    PubMed  CAS  Google Scholar 

  • Dennis, E.D., Mitchell, G.H., Butcher, G.A. & Cohen, S. 1975. In vitro isolation of Plasmodium knowlesi merozoites using polycarbonate sieves. Parasitology 71: 475–481.

    Article  PubMed  CAS  Google Scholar 

  • Diggs, C.L. & Osler, A.G. 1975. Humoral immunity in rodent malaria. III. Studies on the site of antibody action. J. Immunol. 114: 1243–1247.

    PubMed  CAS  Google Scholar 

  • Dvorak, J.A., Miller, L.H., Whitehouse, W.C. & Shiroishi, T. 1975. Invasion of erythrocytes by malaria merozoites. Science 187: 748–750.

    Article  PubMed  CAS  Google Scholar 

  • Freund, J., Thomson, K.J., Sommer, H.E., Walter, A.W. & Pisani, T.M. 1948. Immunization of monkeys against malaria by means of killed parasites with adjuvants. Am. J. Trop. Med. 28: 1–22.

    CAS  Google Scholar 

  • Garnham, P.C.C. 1970. Primate malaria. In Immunity to Parasitic Animals. Jackson, G.J., Herman, R. & Singer, I., Eds. Vol. 2: 767–791. Appleton-Century-Crofts, New York, N.Y.

    Google Scholar 

  • Golenser, J., Spira, D.T. & Zuckerman, A. 1975. Neutralizing antibody in rodent malaria. Trans. R. Soc. Trop. Med. Hyg. 69: 251–258.

    Article  PubMed  CAS  Google Scholar 

  • Gregersen, M.I., Bryant, C.A., Hammerle, W.E., Usami, S. & Chien, S. 1967. Flow characteristics of human erythrocytes through polycarbonate sieves. Science 157: 825–827.

    Article  PubMed  CAS  Google Scholar 

  • Jayawardena, A.N., Targett, G.A.T., Leuchars, E., Carter, R.L., Doenhoff, M.J. & Davies, A.J.S. 1975. T-cell activation in murine malaria. Nature (Lond.) 258: 149.

    Article  CAS  Google Scholar 

  • Luzzatto, L. 1974. Genetic factors in malaria. Bull. WHO 50: 195–202.

    PubMed  CAS  Google Scholar 

  • Miller, L.H. 1975. Transfusion malaria. In Transmissable Disease and Blood Transfusion. Greenwalt, T.J. & Jamieson, G.A., Eds.: 241–266. Grune & Stratton, New York, N.Y.

    Google Scholar 

  • Miller, L.H., Aikawa, M. & Dvorak, J.A. 1975. Malaria (Plasmodium knowlesi) merozoites: immunity and the surface coat. J. Immunol. 114: 1237–1242.

    PubMed  CAS  Google Scholar 

  • Miller, L.H., Dvorak, J.A., Shiroishi, T. & Durocher, J.R. 1973. Influence of erythrocyte membrane components on malaria merozoite invasion. J. Exp. Med. 138: 1597–1601.

    Article  PubMed  CAS  Google Scholar 

  • Miller, L.H., Mason, S.J., Dvorak, J.A., McGinniss, M.H. & Rothman, I.K. 1957. Erythrocyte receptors for (Plasmodium knowlesi) malaria: Duffy blood group determinants. Science 189: 561–563.

    Article  Google Scholar 

  • Miller, L.H., Usami, S. & Chien, S. 1971. Alteration in the rheologic properties of Plasmodium knowlesi-infected red cells, a possible mechanism for capillary obstruction.J. Gin. Invest. 50: 1451–1455.

    CAS  Google Scholar 

  • Mitchell, G.H., Butcher, G.A. & Cohen, S. 1973. Isolation of blood-stage merozoites from Plasmodium knowlesi malaria. Int. J. Parasitol. 3: 443–445.

    Article  PubMed  CAS  Google Scholar 

  • Mitchell, G.H., Butcher, G.A. & Cohen, S. 1974. A merozoite vaccine effective against Plasmodium knowlesi malaria. Nature (Lond.) 252: 311–313.

    Article  CAS  Google Scholar 

  • Mitchell, G.H., Butcher, G.A. & Cohen, S. 1975a. Merozoite vaccination against Plasmodium knowlesi malaria. Immunology 29: 397–407.

    PubMed  CAS  Google Scholar 

  • Mitchell, G.H., Butcher, G.A. & Cohen, S. 1975b. Unpublished observations.

    Google Scholar 

  • Phillips, R.S. 1970. Plasmodium berghei: passive transfer of immunity by anti-sera and cells. Exp. Parasitol. 27: 479–495.

    Article  PubMed  CAS  Google Scholar 

  • Phillips, R.S., Wolstencroft, R.A., Brown, I.N., Brown, K.N. & Dumonde, D.C. 1970. Immunity to malaria. 3. Possible occurrence of a cell-mediated immunity to Plasmodium knowlesi in chronically infected and Freund’s complete adjuvant-sensitized monkeys. Exp. Parasitol. 28: 339–355.

    Article  PubMed  CAS  Google Scholar 

  • Richards, W.H.G., Mitchell, G.H., Butcher, G.A. & Cohen, S. 1975. Unpublished observations.

    Google Scholar 

  • Sadun, E.H. 1976. In Immunity to Parasitic Diseases, Cohen, S. & Sadun, E.H., Eds.: Blackwell Scientific Publishing Company, Oxford, England.

    Google Scholar 

  • Schenkel, R.H., Simpson, G.L. & Silverman, P.H. 1973. Vaccination of Rhesus monkeys (Macaca mulatto) against Plasmodium knowlesi by the use of nonviable antigen. Bull WHO 48: 597–604.

    PubMed  CAS  Google Scholar 

  • Simpson, G.L., Schenkel, R.H. & Silverman, P.H. 1974. Vaccination of Rhesus monkeys against malaria by use of sucrose density gradient fractions of Plasmodium knowlesi antigens. Nature (Lond.) 247: 304–305.

    Article  CAS  Google Scholar 

  • Spira, D.T., Silverman, P.H. & Gaines, C. 1970. Anti-thymocyte serum effects on Plasmodium berghei infection in rats. Immunology 19: 759–766.

    PubMed  CAS  Google Scholar 

  • Stechschulte, D.J., 1969. Cell-mediated immunity in rats infected with Plasmodium berghei Mil. Med. 134: 1147–1152.

    CAS  Google Scholar 

  • Targett, G.A.T. & Fulton, J.D. 1965. Immunization of Rhesus monkeys against Plasmodium knowlesi malaria. Exp. Parasitol. 17: 180–193.

    Article  PubMed  CAS  Google Scholar 

  • Trager, W. 1956. The intracellular position of malarial parasites. Trans. R. Soc. Trop. Med. Hyg. 50: 419–420.

    Article  PubMed  CAS  Google Scholar 

  • Trager, W. & Jensen, J.B. 1976. Human malaria parasites in continuous culture. Science 193: 673–675.

    Article  PubMed  CAS  Google Scholar 

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© 1977 Plenum Press, New York

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Cohen, S., Butcher, G.A., Mitchell, G.H. (1977). Immunization Against Erythrocytic Forms of Malaria Parasites. In: Miller, L.H., Pino, J.A., McKelvey, J.J. (eds) Immunity to Blood Parasites of Animals and Man. Advances in Experimental Medicine and Biology, vol 93. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8855-9_7

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  • DOI: https://doi.org/10.1007/978-1-4615-8855-9_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8857-3

  • Online ISBN: 978-1-4615-8855-9

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