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Pathogenesis of Bacterial Meningitis

Relationship to Opsonic Activity in Normal Cerebrospinal Fluid

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Neurobiology of Cerebrospinal Fluid 2

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Abstract

In the preantimicrobial era, acute pyogenic meningitis was almost always fatal and neurological sequelae were common in most survivors.7,18 Despite major advances in antimicrobial chemotherapy, rapid diagnostic techniques, and the development of effective pneumococcal and meningococcal vaccines, the annual incidence and mortality rates for bacterial meningitis have remained essentially unchanged over the past decade. In 1978, more than 4000 cases of acute bacterial meningitis were reported to the Centers for Disease Control, representing a rate of 0.19 cases/ 100,000 population with an overall case-fatality rate of 13.6%.23

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Authors and Affiliations

  1. Section of Infectious Diseases, Department of Internal Medicine, University of Minnesota Medical School and St. Paul-Ramsey Medical Center, St. Paul, Minnesota, 55101, USA

    Robert W. Tofte M.D.

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  1. Robert W. Tofte M.D.
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  1. Division of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA

    James H. Wood M D

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© 1983 Plenum Press, New York

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Tofte, R.W. (1983). Pathogenesis of Bacterial Meningitis. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9269-3_21

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  • DOI: https://doi.org/10.1007/978-1-4615-9269-3_21

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