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Prostaglandins in Cerebrospinal Fluid

Possible Role in Cerebrovascular and Neurological Disease

  • Chapter
Neurobiology of Cerebrospinal Fluid 2

Abstract

Prostaglandins (PGs) are normally found in small or trace amounts in body tissues and cerebrospinal fluid (CSF) in the absence of stimulation. A wide variety of stimuli activate the enzyme phospholipase A2 of cell membranes to release arachidonic acid [cis-5, 8, 11, 14-icosatetraenoic acid (AA)], which is the main precursor of PGs in man.56 This lipid contains 20 carbons and 4 double bonds (C20:4) and is rapidly converted to oxygenated products by two distinct pathways. One pathway involves the enzyme lipoxygenase, which forms a number of unstable compounds (hydroperoxyarachidonic acids) of which little is known, but that may play a role in leukotaxis along with the PGs.73 Lipoxygenase is apparently found only in platelets, lungs, and white cells. The other pathway involves the enzyme cyclooxygenase (prostaglandin synthetase), which produces from AA the endoperoxide PGs (PGG2 and PGH2).

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Authors and Affiliations

  1. Departments of Pharmacology and Neurosurgery, Memphis, Tennessee, 38163, USA

    Richard P. White Ph.D.

  2. Department of Pharmacology, University of Tennessee Center for the Health Sciences, Memphis, Tennessee, 38163, USA

    A. Ainsworth Hagen Ph.D.

  3. Department of Neurosurgery, University of Tennessee Center for the Health Sciences, Memphis, Tennessee, 38163, USA

    James T. Robertson M.D.

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  1. Division of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA

    James H. Wood M D

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White, R.P., Hagen, A.A., Robertson, J.T. (1983). Prostaglandins in Cerebrospinal Fluid. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9269-3_35

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