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Effect of Mannitol-Induced Hyperosmolarity on Transport between Brain Interstitial Fluid and Cerebrospinal Fluid

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Neurobiology of Cerebrospinal Fluid 2

Abstract

Osmotic agents, such as urea18 and mannitol,52 have been used for over 20 years to treat increased intracranial pressure (ICP). The usefulness of the currently used agent, mannitol, had been limited by the fluid and electrolyte disturbances that occurred with the recommended dosages of 2–4 g/kg. To overcome these limitations, lower mannitol dosages of 0.25–1.5 g/kg have been tested in patients and found to be effective in temporarily controlling ICP.22, 26

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Author information

Authors and Affiliations

  1. Department of Neurology, School of Medicine, USA

    Gary A. Rosenberg M.D.

  2. Department of Mathematics and Statistics, University of New Mexico, Albuquerque, New Mexico, 87131, USA

    Walter T. Kyner Ph.D.

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  1. Gary A. Rosenberg M.D.
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  2. Walter T. Kyner Ph.D.
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  1. Division of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA

    James H. Wood M D

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© 1983 Plenum Press, New York

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Rosenberg, G.A., Kyner, W.T. (1983). Effect of Mannitol-Induced Hyperosmolarity on Transport between Brain Interstitial Fluid and Cerebrospinal Fluid. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9269-3_49

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  • DOI: https://doi.org/10.1007/978-1-4615-9269-3_49

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9271-6

  • Online ISBN: 978-1-4615-9269-3

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