Abstract
A number of general considerations are applicable to the action of chemical agents on membrane functions (7, 11):
-
a)
It is self evident but important that chemical agents act from the outside toward the inside of the cell. The membrane, and particularly its outer surface, is the first site of action. With slowly penetrating agents the sequence of interactions from outside in, and of their related effects, can be followed as a function of time.
-
b)
Which membrane ligands will react with any given agent depends not only on their chemical reactivities but also on their location in the membrane and the ability of the agent to diffuse to their vicinity.
-
c)
This paper is based on work performed under contract with the U.S. Atomic Energy Commission at the University of Rochester Atomic Energy Project and has been assigned Report No. UR-3490-1.
This paper is based on work performed under contract with the U.S. Atomic Energy Commission at the University of Rochester Atomic Energy Project and has been assigned Report No. UR-3490-1.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Berg, H.C., J.M. Diamond and P.S. Marfey. Erythrocyte membrane: chemical modification. Science 150:, 64 (1965).
Oeuticke, B. Anion permeability of the red blood cell. Naturwissenschaften 57:, 172 (1970).
Eylar, E.H., M.A. Madoff, O.V. Prady and J.L. Oncley. The contribution of sialic acid to the surfase charge of the erythrocyte. J. Biol. Chem. 237:, 1992 (1962).
Knauf, P.A. and A. Rothstein. Chemical modification of membranes. I. Effects of sulfhydryl and amino reactive reagents on anion and cation permeability of the human red blood cell. J. Gen. Physiol. 58:, 190 (1971).
Knauf, P.A. and A. Rothstein. Chemical modification of membranes. II. Permeation paths for sulfhydryl agents. J. Gen. Physiol.58:, 211 (1971).
Passow, H. Passive ion permeability of the erythrocyte membrane. In: “Progress in Biophysics and Molecular Biology” (eds., J.A.V. Butler and D. Noble) Vol. 19, part II (1969). Pergamon Press.
Passow, H., A. Rothstein and T.W. Clarkson. The general pharmacology of the heavy metals. Pharmacol. Rev. 13:, 185 (1961).
Passow, H. and K.F. Schnell. Chemical modifiers of passive ion permeability of the erythrocyte membrane. Experientia 25:, 460 (1969).
Poensgen, J. and H. Passow. Action of 1-fluoro-2,4-di- nitrobenzene on passive ion permeability of the human red blood cell. J. Membrane Biol. (1971). In press.
Rega, A.F., A. Rothstein and R.I. Weed. Erythrocyte membrane sulfhydryl groups and the active transport of cations. J. Cell. Physiol. 75:, 45 (1967).
Rothstein, A. Sulfhydryl groups in membrane structure and function. In: “Current Topics in Membranes and Transport”. Vol. 1, pp. 135 (1970). Academic Press, New York.
Shapiro, B., G. Kollmann and D. Martin. The diversity of sulfhydryl groups in the human erythrocyte. J. Cell. Physiol. 75:, 281 (1970).
Stein, W.D. A procedure which labels the active center of the glucose transport system of the human erythrocyte. In: “The Structure and Activity of Enzymes”, (eds. T.W. Goodwin, B.S. Hartley and J.I. Harris), p. 133 (1964). Academic Press, New York.
Sutherland, R.M., A. Rothstein and R.I. Weed. Erythrocyte membrane sulfhydryl groups and cation permeability. J. Cell. Physiol. 65:, 185 (1967).
Sutherland, R.M., J.N. Stannard and R.I. Weed. Involvement of sulfhydryl groups in radiation damage to the human erythrocyte membrane. Int. J. Radiat. Biol. 12:, 551 (1967).
Van Steveninck, J., R.I. Weed and A. Rothstein. Localization of erythrocyte membrane sulfhydryl groups essential for glucose transport. J. Gen. Physiol.48:, 617 (1965).
Webb, J.L. Enzyme and Metabolic Inhibition, Vol. 2, Chapters 4 and 7. Academic Press, New York (1965).
Weed, R.I., J. Eber and A. Rothstein. Interaction of mercury with human erythrocytes. J. Gen. Physiol.45:, 395 (1962).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1972 Plenum Press, New York
About this chapter
Cite this chapter
Rothstein, A., Takeshita, M., Knauf, P.A. (1972). Chemical Modification of Proteins Involved in the Permeability of the Erythrocyte Membrane to Ions. In: Kreuzer, F., Slegers, J.F.G. (eds) Biomembranes : Passive Permeability of Cell Membranes. Biomembranes, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0961-1_28
Download citation
DOI: https://doi.org/10.1007/978-1-4684-0961-1_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-0963-5
Online ISBN: 978-1-4684-0961-1
eBook Packages: Springer Book Archive