Abstract
Pinocytosis is a mechanism for the transport of molecules from the exterior to the interior of the cell without transfer through the plasma membrane. Transport of molecules occurs when the membrane wraps around the external material to form vesicles which are pinched off and internalized. The vesicles fuse with lysosomes, the contents of which become enriched with the material brought in from the outside. If the area of the plasma membrane which is internalized has receptors to which a particular substance is tightly bound, that substance is delivered to lysosomes far more efficiently and selectively than if it were simply trapped within the pinocytotic vesicle. In recent years, receptor-mediated pinocytosis systems have been described for substances as diverse as cholesterol esters, vitamin B12, hormones and growth factors, circulating glycoproteins, and hydrolytic enzymes. It is the last two groups, which involve the recognition of specific carbohydrate residues, that are the subject of this chapter.
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Neufeld, E.F., Ashwell, G. (1980). Carbohydrate Recognition Systems for Receptor-Mediated Pinocytosis. In: Lennarz, W.J. (eds) The Biochemistry of Glycoproteins and Proteoglycans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1006-8_6
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