Skip to main content
SpringerLink
Log in

Immunology of Herpes Simplex Viruses

  • Chapter
Immunology of Human Infection

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 9))

Abstract

Herpes simplex viruses (HSV) belong to a family of over 70 viruses—Herpesviridae— which have the following main characteristics: They consist of a core surrounded successively by an icosadeltahedral capsid, a globular tegument, and an envelope derived primarily from the nuclear membrane. There are two distinct serotypes of herpes simplex viruses (HSV-1 and HSV-2) which can be differentiated by serological, biological, and biochemical means and which share about half their base sequences [151].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ades, E. W., Dougherty, P., Shore, S. L., and Balch, C. M., 1979, E-rosette receptors induced by phytohemagglutinin on human K cells expressing T-cell surface antigens. Cell Immunol. 44:179–185.

    Article  PubMed  CAS  Google Scholar 

  2. Adler, R., Glorioso, J. C., Cossman, J. C., and Levine, M., 1978, Possible role of Fc receptors on cells infected and transformed by herpesvirus: Escape from immune cytolysis. Infect. Immun. 21:441–447.

    Google Scholar 

  3. Allen, J. A., Cooper, C., Daniels, C. A., and Trofatter, K. F., 1978, The effect of prednisolone on antibody-dependent cell-mediated cytotoxicity and the growth of type 1 herpes simplex virus in human cells. Infest. Ophthalmol. Vis. Sci. 17:381–384.

    Google Scholar 

  4. Allison, A. C., 1974, Interaction of antibodies, complement components and various cell types in immunity against viruses and pyogenic bacteria. Transplant. Rev. 19:3–55.

    PubMed  CAS  Google Scholar 

  5. Amstey, M. S., 1977, Effect of pregnancy hormoneson herpesvirus and other deoxyribonucleic acid viruses. Am, J. Obstet. Gynecol. 129:159–163.

    CAS  Google Scholar 

  6. Anzai, T., Dreesman, G. R., Courtney, R. J., 1975, Antibody to herpes simplex virus type 2-induced nonstructural proteins in women with cervical cancer and in control groups, J. Natl. Cancer Inst. 54:1051–1059.

    PubMed  CAS  Google Scholar 

  7. Araby, I. I. E., Chernesky, M. A., Rawls, W. E., and Dent, P. B., 1978, Depressed herpes simplex virus-induced lymphocyte blastogenesis in individuals with severe recurrent herpes infections, Clin. Immunol. Immunopathol. 9:253–263.

    Article  PubMed  Google Scholar 

  8. Ardenson, S. G., Hamilton, J., and Williams, S., 1950, An attempt to vaccinate against herpes simplex, Aust. J. Exp. Biol. Med. Sci. 28:579–584.

    Article  Google Scholar 

  9. Ashe, W. K., and Notkins, A. L., 1967, Kinetics of sensitization of herpes simplex virus and its relationship to the reduction in the neutralization rate constant. Virology 33:613–617.

    Article  PubMed  CAS  Google Scholar 

  10. Ashe, W. K., Mage, M., Mage, R., and Notkins, A. L., 1968, Neutralization and sensitization of herpes simplex virus with antibody fragments from rabbits of different allotypes, J. Immunol. 101:500–504.

    PubMed  CAS  Google Scholar 

  11. Ashman, R. B., and Nahmias, A. J., 1978, Effect of incubation temperature on mitogen responses of lymphocytes from adult peripheral blood and from cord blood, Clin. Exp. Immunol. 33:319–326.

    PubMed  CAS  Google Scholar 

  12. Aurelian, L., and Strand, B. C., 1976, Herpesvirus type 2-related antigens and their relevance to humoral and cell-mediated immunity in patients with cervical cancer. Cancer Res. 36:810–820.

    PubMed  CAS  Google Scholar 

  13. Aurelian, L., Smith, M. F., and Cornish, D. J., 1976, IgM antibody to a tumor-associated antigen (Ag- 4) induced by herpes simplex virus type 2: Its use in location of the antigen in infected cells, J. Natl. Cancer Inst. 56:471–477.

    PubMed  CAS  Google Scholar 

  14. Austin, R. M., and Daniels, C. A., 1975, Effect of staphylococcal protein A on complement-potentiated neutralization of herpes simplex virus and immune lysis of virus-infected cells. Infect. Immun. 12:821–827.

    PubMed  CAS  Google Scholar 

  15. Azulay, R. D., Monteiro, E. de F., Cunha, W., and Azulay, E., 1971, Vacinoterapia especifica no herpes simplex (1): Ensaios clinicos no herpes mucocutaneo, O Hospital 80:251–261.

    Google Scholar 

  16. Babiuk, L. A., Wardley, R. C., and Rouse, B. T., 1975, Defense mechanisms against bovine herpesvirus: Relationship of virus-host cell events to susceptibility to antibody-complement cell lysis. Infect. Immun. 12:958–963.

    PubMed  CAS  Google Scholar 

  17. Baker, D. A., and Plotkin, S. A., 1978, Enhancement of vaginal infection in mice by herpes simplex virus type 1 with progesterone, Proc. Soc. Exp. Biol. Med. 158:131–134.

    PubMed  CAS  Google Scholar 

  18. Baron, S., Worthington, M. G., Williams, J., and Gaines, J. W., 1976, Postexposure serum prophylaxis of neonatal herpes simplex virus infection of mice. Nature (London) 261:505–506.

    Article  CAS  Google Scholar 

  19. Baringer, J. R., 1975, Herpes simplex virus infection of nervous tissue in animals and man, Prog. Med. Virol. 20:1–25.

    PubMed  CAS  Google Scholar 

  20. Bauche, R. B., and Spear, P. G., 1979, Membrane proteins specified by herpes simplex viruses. V. Identification of an Fc-binding glycoprotein, J. Virol. 32:779–789.

    Google Scholar 

  21. Bell, R. B., Aurelian, L., and Cohen, G. H., 1978, Proteins of herpesvirus type 2. IV. Leukocyte inhibition responses to type common antigens in cervix cancer and recurrent herpetic infections, Cell. Immunol. 41:86–102.

    Article  PubMed  CAS  Google Scholar 

  22. Ben-Zvi, A., Soffer, D., and Yatziv, S., 1978, Disseminated herpes simplex virus infection in ataxia telangiectasia. Acta Paediatr. Scand. 67:667–670.

    Article  PubMed  CAS  Google Scholar 

  23. Bierman, S. M., 1976, BCG Immunoprophylaxis of recurrent herpes progenitalis, Arch. Dermatol. 112:1410–1415.

    Article  PubMed  CAS  Google Scholar 

  24. Blank, H., and Haines, H. G., 1973, Experimental human reinfection with herpes simplex virus, J. Invest. Dermatol. 61:223–225.

    Article  PubMed  CAS  Google Scholar 

  25. Brier, A. M., Snyderman, R., Mergenhagen, S. E., and Notkins, A. L., 1970, Inflammation and herpes simplex virus: Release of a chemotaxis generating factor from infected cells, Science 170:1104–1106.

    Article  PubMed  CAS  Google Scholar 

  26. Brier, A. M., Wohlenberg, C., Rosenthal, J., Mage, M., and Notkins, A. L., 1971, Inhibition or enhancement of immunological injury of virus-infected cells, Proc. Natl. Acad. Sci. USA 68:3073–3077.

    Article  PubMed  CAS  Google Scholar 

  27. Brown, E. W., Burdash, N. M., Manos, J. P., and Duncan, R. C., 1977, MIF-like activity in non-stimulated and virus-infected cell cultures (abstract), Annual Meeting of the American Society for Microbiology, E185, p. 111.

    Google Scholar 

  28. Bubola, D., and Olivetti, L., 1968, L’intradermoreazione con virus erpetico innattivato. I. Analisi de jattori che influenzano la reasione, G. Ital. Dermatol. 109:363–376.

    CAS  Google Scholar 

  29. Buchman, T. G., Roizman, B., and Nahmias, A. J., 1981, Structure of herpes simplex virus DNA and application to molecular epidemiology, Ann. N. Y. Acad. Sci. 354:279–290.

    Article  Google Scholar 

  30. Buddingh, G. J., Schrum, D. I., Lanier, J. C., and Guidry, D. J., 1953, Studies on the natural history of herpes simplex infections, Pediatrics 11:595–610.

    PubMed  CAS  Google Scholar 

  31. Bums, W. H., Billups, L. C., and Notkins, A. L., 1975, Thymus dependence of viral antigens, Nature (London) 256:654–655.

    Article  Google Scholar 

  32. Camacho, A., and Spear, P., 1979, Transformation of hamster embryo fibroblasts by a specific fragment of herpes simplex virus genome. Cell 15:993–1002.

    Article  Google Scholar 

  33. Cappel, R., 1976, Comparison of the humoral and cellular immune responses after immunization with live, UV-inactivated herpes simplex virus and a subunit vaccine and efficacy of these immunization, Arch. Virol. 52:29–35.

    Article  PubMed  CAS  Google Scholar 

  34. Carmichael, L. E., Barnes, F. O., and Perez, D. H., 1970, Temperature as a factor in resistance of young puppies to canine herpesvirus, J. Infect. Dis. 120:669–673.

    Article  Google Scholar 

  35. Carritt, B., and Goldfarb, P., 1976, A human chromosomal determinant for susceptibility to herpes simplex virus. Nature (London) 264:556–558.

    Article  CAS  Google Scholar 

  36. Catalano, L. W., London, W. T., Rice, J. M., and Sever, J. L., 1972, Prophylactic and therapeutic use of poly (I) Poly (C) [Poly-D-lysine] against herpesvirus encephalitis in mice, Proc. Soc. Exp. Biol. Med. 140:66–71.

    PubMed  CAS  Google Scholar 

  37. Centifanto, Y. M., Drylie, D. M., Deardourff, S. L., and Kaufman, H., 1972, Herpesvirus type 2 in the male genitourinary tract, Science 178:318–319.

    Article  PubMed  CAS  Google Scholar 

  38. Centifanto, Y. M., Little, J. M., and Kaufman, H. E., 1970, The relationship between virus chemotherapy, secretory antibody formation, and recurrent herpetic disease, Ann. N.Y. Acad. Sci. 173:649–656.

    Article  CAS  Google Scholar 

  39. Centifanto, Y. M., Zam, Z. S., and Kaufman, H. E., 1977, In vitro studies on the mechanism of herpesvirus plaque growth inhibition by sensitized lymphocytes, Infect. Immun. 17:350–355.

    PubMed  CAS  Google Scholar 

  40. Cheeseman, S. H., Rubin, R. H., Stewart, J. A., Tolkoff-Rubin, N. E., Cosimi, A. B., Cantell, K., Gilbert, J., Winkle, S., Herrin, J. T., Black, P. H., Russell, P. S., and Hirsch, M. S., 1979, Controlled clinical trial of prophylactic human-leukocyte interferon in renal transplantation, N. Engl. J. Med. 300:1345–1349.

    Article  PubMed  CAS  Google Scholar 

  41. Ching, C., and Lopez, C., 1979, Natural killing of herpes simplex virus type 1-infected target cells: Normal human responses and influence of antiviral antibody, Infect. Immun. 26:49–56.

    PubMed  CAS  Google Scholar 

  42. Chipps, B. E., Saulsbury, F. T., Hsu, S. H., Hughes, W. H., Winkelstein, J. A., 1979, Non-candidal infections in children with chronic mucocutaneous candidiasis, Johns Hopkins Med. J. 144:175–179.

    PubMed  CAS  Google Scholar 

  43. Christenson, B., and Espmark, A., 1976, Long-term follow-up studies on herpes simplex antibodies in the course of cervical cancer. II. Antibodies to surface antigen of herpes simplex virus infected cells, Int. J. Cancer 17:318–325.

    Article  PubMed  CAS  Google Scholar 

  44. Christenson, B., 1978, Antibody-dependent cell-mediated cytotoxicity to herpes simplex virus type 2 infected target cells in the course of cervical carcinoma, Am. J. Epidemiol. 108:126–135.

    PubMed  CAS  Google Scholar 

  45. Clancy, R., Rawls, W. E., and Jagannath, S., 1977, Appearance of cytotoxic cells within the bronchus after local infection with herpes simplex virus, J. Immunol. 119:1102–1105.

    PubMed  CAS  Google Scholar 

  46. Cooper, N. R., Jensen, F. C., Welsh, R. M., and Oldstone, M. B. A., 1976, Lysis of RNA tumor viruses by human serum: Direct antibody-independent triggering of the classical complement pathway, J. Exp. Med. 144:970–981.

    Article  PubMed  CAS  Google Scholar 

  47. Corey, L., Reeves, W. C., and Holmes, K. K., 1978, Cellular immune responses in genital herpes simplex virus infection, N. Engl. J. Med. 299:986–991.

    Article  PubMed  CAS  Google Scholar 

  48. Costa, J. C., and Rabson, A. S., 1975, Role of Fc receptors in herpes simplex virus infection. Lancet 1:77–78.

    Article  PubMed  CAS  Google Scholar 

  49. Costa, J., Rabson, A. S., Yee, C., and Tralka, T. S., 1977, Immunoglobulin binding to herpes virus-induced Fc receptors inhibits virus growth. Nature (London) 269:251–252.

    Article  CAS  Google Scholar 

  50. Cromeans, T. L., Milgrom, H., and Shore, S. L., 1979, Antibody-dependent cellular cytotoxicity in high concentrations of human serum (abstract). Annual Meeting of American Society for Microbiology, E27, p. 59.

    Google Scholar 

  51. Daniels, C. A., Kleinerman, E. S., and Snyderman, R., 1978, Abortive and productive infection of human mononuclear phagocytes by type 1 herpes simplex virus. Am. J. Pathol. 91:119–36.

    PubMed  CAS  Google Scholar 

  52. Daniels, C. A., Borsos, T., Rapp, H. J., Snyderman, R., and Notkins, A. L., 1970, Neutralization of sensitized virus by purified components of complement, Proc. Natl. Acad. Sci. USA 65:528–535.

    Article  PubMed  CAS  Google Scholar 

  53. Daniels, C. A., LeGoff, S. G., and Notkins, A. L., 1975, Shedding of infections virus/antibody complexes from vesicular lesions of patients with recurrent herpes labialis. Lancet 2:524–528.

    Article  PubMed  CAS  Google Scholar 

  54. Davis, L. E., and Johnson, R. T., 1979, An explanation for the localization of herpes simplex encephalitis, Ann. Neurol. 5:2–5.

    Article  PubMed  CAS  Google Scholar 

  55. Day, R. P., Bienenstock, J., and Rawls, W. E., 1976, Basophil-sensitizing antibody response to herpes simplex viruses in rabbits, J. Immunol. 117:73–78.

    PubMed  CAS  Google Scholar 

  56. de la Pena, N. C., Diaz, A., Damel, A., Bal, E., Puricelli, L., Ejden, J., and deLustig, E. S., 1978, Combined therapy of human interferon (HI) and secretory immunoglobulin (S-IgA) in the treatment of humans herpetic keratitis, Biomedicine 28: 104–108.

    PubMed  Google Scholar 

  57. Denman, A. M., Pelton, B. K., Appleford, D., and Kinsley, M., 1976, Virus infections of the lymphoreticular cells and auto-immune diseases. Transplant Rev. 31:79–115.

    PubMed  CAS  Google Scholar 

  58. Denman, A. M., Rager-Zisman, B., Merigan, T. C., and Tyrrell, D. A. J., 1974, Replication or inactivation of different viruses by human lymphocyte preparations. Infect. Immun. 9:373–376.

    PubMed  CAS  Google Scholar 

  59. Doerr, H. W., Gross, G., and Schmitz, H., 1976, Neutralizing serum IgM antibodies in infections with herpes simplex virus hominis, Med. Microbiol. Immunol. 162:183–192.

    Article  PubMed  CAS  Google Scholar 

  60. Douglas, R. G., Jr., and Couch, R. B., 1970, A prospective study of chronic herpes simplex virus infection and recurrent herpes labialis in humans, J. Immunol. 104:289–295.

    PubMed  CAS  Google Scholar 

  61. Duff, R., Doller, E., and Rapp, F., 1973, Immunologic manipulation of metastases due to herpesvirus transformed cells. Science 180:79–81.

    Article  PubMed  CAS  Google Scholar 

  62. Duff, R., and Rapp, F., 1971, Properties of hamster embryo fibroblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2, J. Virol. 8:469–477.

    PubMed  CAS  Google Scholar 

  63. Dunnick, J. K., and Galasso, G. J., 1979, Clinical trials with exogenous interferon—Summary of a meeting, J. Infect. Dis. 139:109–112.

    Article  PubMed  CAS  Google Scholar 

  64. Ennis, F. A., 1973, Host defense mechanisms against herpes simplex virus. Infect. Immun. 7:898–904.

    PubMed  CAS  Google Scholar 

  65. Ennis, F. A., 1973, Host defense mechanisms against herpes simplex virus. II. Protection conferred by sensitized spleen cells, J. Infect. Dis. 127:632–638.

    Article  PubMed  CAS  Google Scholar 

  66. Ennis, F. A., and Wells, M., 1974, Immune control of herpes simplex virus infections, Cancer Res. 34:1140–1145.

    PubMed  CAS  Google Scholar 

  67. Fadnes, H. O., 1975, Protein concentration and hydrostatic pressure in subcutaneous tissue of rats in hypoproteinemia, Scand. J. Clin. Lab. Invest. 35:441–446.

    Article  PubMed  CAS  Google Scholar 

  68. Fanta, D., Topaloglon, A., and Altmann, H., 1978, Studies on the DNA-excision repair in lymphocytes of patients with recurrent herpes simplex, Bull. Cancer 65:341–346.

    PubMed  CAS  Google Scholar 

  69. Flanagan, J. F., 1966, Hydrolytic enzymes in KB cells infected with poliovirus and herpes simplex virus, J. Bacteriol. 91:789–797.

    PubMed  CAS  Google Scholar 

  70. Flewett, T. H., Parker, R. G. F., and Philip, W. M., 1969, Acute hepatitis due to herpes simplex virus in an adult, J. Clin. Pathol. 22:60–66.

    Article  PubMed  CAS  Google Scholar 

  71. Forghani, B., Klassen, T., and Baringer, J. R., 1977, Radioimmunoassay of herpes simplex virus antibody: Correlation with ganglionic infection, J. Gen. Virol. 36:371–375.

    Article  PubMed  CAS  Google Scholar 

  72. Frank, U., Schindling, B., Lindermann, J., and Falke, D., 1978, Multiplication of herpes simplex virus types 1 and 2 in macrophages of NMRI and C57/BL mice, Acta Virol. 22:193–202.

    PubMed  CAS  Google Scholar 

  73. Fritz, M. E., and Nahmias, A. J., 1972, Reversed polarity in transmembrane potentials of cells infected with herpesviruses, Proc. Soc. Exp. Biol. Med. 139:1159–1161.

    PubMed  CAS  Google Scholar 

  74. Fujibayashi, T., Hooks, J. J., and Notkins, A. L., 1975, Production of interferon by immune lymphocytes exposed to herpes simplex virus-antibody complexes, J. Immunol. 115:119–193.

    Google Scholar 

  75. Fujimiya, Y., Rouse, B. T., and Babiuk, L. A., 1978, Human neutrophil-mediated destruction of antibody sensitized herpes simplex virus type 1 infected cells. Can. J. Microbiol. 24:182–186.

    Article  PubMed  CAS  Google Scholar 

  76. Galloway, D. A., Fenoglio, C., Shevcuk, M., and McDougall, J. K., 1979, Detection of herpes simplex RNA in human sensory ganglia. Virology 95:265–268.

    Article  PubMed  CAS  Google Scholar 

  77. Gange, R. W., DeBats, A., Park, J. R., Bradstreet, C. M. P., and Rhodes, E. L., 1975, Cellular immunity and circulating antibody to herpes simplex virus in subjects with recurrent herpes simplex lesions and controls as measured by the mixed leukocyte migration inhibition test and complement fixation, Br. J. Dermatol. 97:539–544.

    Article  Google Scholar 

  78. Glasgow, L. A., and Habel, K., 1963, Role of polyoma virus and interferon in a herpes simplex infection in vitro, Virology 19:328–339.

    Article  PubMed  CAS  Google Scholar 

  79. Glezen, W. P., Fernald, G. W., and Lohr, J. A., 1975, Acute respiratory disease of university students with special reference to the etiologic role of herpesvirus hominis, Am. J. Epidemiol. 101:111–121.

    PubMed  CAS  Google Scholar 

  80. Glorioso, J., and Smith, J. W., 1977, Immune interactions with cells infected with herpes simplex virus: Antibodies to radioiodinated surface antigens, J. Immunol. 118:114–121.

    PubMed  CAS  Google Scholar 

  81. Godfrey, R. C., 1972, Resistance to intracerebral challenge in mice immunized against herpes simplex virus, Br. J. Exp. Pathol. 53:529–538.

    PubMed  CAS  Google Scholar 

  82. Goldman, L., 1961, Reactions of autoinoculation from recurrent herpes simplex. Arch. Dermatol. 84:1025–1026.

    Article  PubMed  CAS  Google Scholar 

  83. Gordon, D. S., and Shore, S. L., 1980, Antibody-dependent cellular cytotoxicity to virus-infected target cells: Role of nylon wool-adherent T cells as effectors, Cell. Immunol. 50:19–29.

    Article  PubMed  CAS  Google Scholar 

  84. Gresser, I., Tovey, M. G., Bandu, M. T., Maury, C., and Brouty-Boye, D., 1976, Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum, J. Exp. Med. 144:1305–1323.

    Article  PubMed  CAS  Google Scholar 

  85. Guerra, R., Galin, M. A., and Frezotte, R., 1977, Use of interferon in eye infections in man, Texas Rep. Biol. Med. 35:497–502.

    CAS  Google Scholar 

  86. Haahr, S., Rasmussen, L., and Merigan, T. C., 1976, Lymphocyte transformation and interferon production in human mononuclear cell microcultures for assay of cellular immunity to herpes simplex virus. Infect. Immunol. 14:47–54.

    CAS  Google Scholar 

  87. Hampar, B., Notkins, A. L., Mage, M., and Keehn, M. A., 1968, Heterogenicity in the properties of 7 S and 19 S rabbit-neutralizing antibodies to herpes simplex virus, J. Immunol. 100:586–593.

    PubMed  CAS  Google Scholar 

  88. Hill, T. J., and Blyth, W. A., 1976, An alternative theory of herpes simplex recurrence and a possible role for prostaglandins. Lancet 1:397–398.

    Article  PubMed  CAS  Google Scholar 

  89. Hilleman, M., and Larson, V., 1979, Comments at Proceedings of the Experimental Herpesvirus Vaccine Workshop, FDA, BOB (February 9, 1979).

    Google Scholar 

  90. Hirsch, M. S., Zisman, B., and Allison, A. C. 1970, Macrophages and age-dependent resistance to herpes simplex virus in mice, J. Immunol. 104:1160–1165.

    PubMed  CAS  Google Scholar 

  91. Hollinshead, A. C., Chretien, P. B., Lee, O’B., Tarpley, J. L., Kerney, S. E., Silverman, N. A., and Alexander, J. C., 1976, In vivo andin vitro measurements of the relationship of human squamous carcinomas to herpes simplex virus tumor-associated antigens. Cancer Res. 36:821–828.

    PubMed  CAS  Google Scholar 

  92. Honess, R. W., and Watson, D. H., 1977, Unity and diversity in the herpesviruses, J. Gen. Virol. 37:15–24.

    Article  PubMed  CAS  Google Scholar 

  93. Hurwitz, E., Zatz, M. M., and Segal, D. M., 1977, The biological activity of affinity cross-linked oligimers of rabbit immunoglobulin G as tested by antibody-dependent cell-mediated cytolysis (ADCC), J. Immunol. 118:1348–1353.

    PubMed  CAS  Google Scholar 

  94. Ibrahim, A. N., Ray, M., Megaw, J., Brown, R., and Nahmias, A. J., 1976, Common antigens of herpes simplex virus 2, associated hamster tumors, and human cervical cancer, Proc. Soc. Exp. Biol. Med. 152:343–347.

    PubMed  CAS  Google Scholar 

  95. Ida, S., Hooks, J. J., Siraganian, R. P., and Notkins, A. L., 1977, Enhancement of IgE mediated histamine release from human basophils by viruses: Role of interferon, J. Exp. Med. 145:892–906.

    Article  PubMed  CAS  Google Scholar 

  96. Ito, H., Tsutsui, F., Kurihara, S., Akabayashi, T., Tobe, T., and Nishimura, C., 1976, Serum antibodies to herpesvirus early antigens in patients with cervical carcinoma determined by anticomplement immunofluorescence technique. Int. J. Cancer 18:557–563.

    Article  PubMed  CAS  Google Scholar 

  97. Jacobs, R. P., Aurelian, L., and Cole, G. A., 1976, Cell-mediated immune response to herpes simplex virus: Type-specific lymphoproliferative responses in lymph nodes draining the site of primary infection, J. Immunol. 116:1520–1525.

    PubMed  CAS  Google Scholar 

  98. Johnson, R. T., 1964, The pathogenesis of herpes virus encephalitis. II. A cellular basis for the development of resistance with age, J. Exp. Med. 120:359–373.

    Article  PubMed  CAS  Google Scholar 

  99. Juretic, M., 1966, Natural history of herpetic infection, Helv. Paediat. Acta 21:355–368.

    Google Scholar 

  100. Kalimo, K. O. K., Marttila, R. J., Granfors, K., and Viljanen, M. K., 1976, Solid-phase radioimmunoassay of human immunoglobulin M and immunoglobulin G antibodies against herpes simplex virus type 1 capsid, envelope, and excreted antigens, Infect. Immun. 15:883–889.

    Google Scholar 

  101. Kawana, T., Cornish, J. D., Smith, M. F., and Aurelian, L., 1976, Frequency of antibody to a virus-induced, tumor-associated antigen (Ag-4) in Japanese sera from patients with cervical cancer and controls. Cancer Res. 36:1910–1914.

    PubMed  CAS  Google Scholar 

  102. Keddie, F. M., Rees, R. B., and Epstein, N. N., 1941, Herpes simplex following artificial fever therapy, J. Am. Med. Assoc. 117:1327–1330.

    Article  CAS  Google Scholar 

  103. Kern, A. B., and Scheff, B. L., 1959, Smallpox vaccination in the management of recurrent herpes simplex: A controlled evaluation, J. Invest. Dermatol. 33:99–102.

    Article  PubMed  CAS  Google Scholar 

  104. Kirchner, H., Hurt, H. M., Kleincke, C., and Münk, K., 1976, Replication of herpes simplex virus in mouse spleen cell culture stimulated by lipopolysaccharides, J. Immunol. 117:1753–1756.

    PubMed  CAS  Google Scholar 

  105. Kirchner, H., Zawatzky, R., and Hirt, H. M., 1978, In vitro production of immune interferon by spleen cells of mice immunized with herpes simplex virus.Cell. Immunol. 40:204–210.

    Article  PubMed  CAS  Google Scholar 

  106. Kitces, E. N., Morahan, P. S., Tew, J. G., and Murray, B. K., 1977, Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine. Infect. Immun. 16:955–960.

    PubMed  CAS  Google Scholar 

  107. Klein, R., 1976, Latency of herpes simplex virus. Arch. Virol. 51:1–13.

    Article  PubMed  CAS  Google Scholar 

  108. Kleinerman, E. S., Snyderman, R., and Daniels, C. A., 1974, Depression of human monocyte chemotaxis by herpes simplex and influenza viruses, J. Immunol. 113:1562–1567.

    PubMed  CAS  Google Scholar 

  109. Kleinman, L. F., Kibrick, S., Ennis, F., and Polgar, P., 1972, Herpes simplex virus replication in human lymphocyte culture stimulated with phytomitogehs and anti-lymphocyte globulin, Proc. Soc. Exp. Biol. Med. 141:1095–1099.

    PubMed  CAS  Google Scholar 

  110. Kohl, S., Cahall, D. L., Walters, D. L., and Schaffner, V. E., 1979, Murine antibody-dependent cellular cytotoxicity to herpes simplex virus-infected target cells, J. Immunol. 123:25–30.

    PubMed  CAS  Google Scholar 

  111. Kohl, S., Pickering, L. K., Sullivan, M. P., Walters, D. L., 1980, Impaired monocyte-macrophage cytotoxicity in patients with Hodgkin’s disease, Clin. Immunol. Immunopathol. 15:577–585.

    Article  PubMed  CAS  Google Scholar 

  112. Kohl, S., Malloy, M. M., Pickering, L. K., Morriss, F. H., Adcock, E. W., and Walter, D. L., 1978, Human colostral cytotoxicity. I. Antibody-dependent cellular cytotoxicity against herpes simplex viral-infected cells mediated by colostral cells, J. Clin. Lab. Immunol. 1:221–224.

    PubMed  CAS  Google Scholar 

  113. Kohl, S., Shaban, S. S., Starr, S. E., Wood, P. A., and Nahmias, A. J., 1978, Human neonatal and maternal monocyte-macrophage and lymphocyte-mediated antibody-dependent cytotoxicity to cells infected with herpes simplex, J. Pediatr. 93:206–210.

    Article  PubMed  CAS  Google Scholar 

  114. Kohl, S., Starr, S. E., Oleske, J. M., Shore, S. L., Ashman, R. B., and Nahmias, A. J., 1977, Human monocyte-macrophage-mediated antibody-dependent cytotoxicity to herpes simplex virus-infected cells, J. Immunol 118:729–735.

    PubMed  CAS  Google Scholar 

  115. Krueger, G. G., Spruance, S. L., and Overall, J. C., 1978, Herpes simplex labialis — A review of pathogenesis, natural history and therapy, J. C. E. Dermatology 7:19–88.

    Google Scholar 

  116. Kurata, T., Kurata, K., and Aoyama, Y., 1978, Vertical transmission of type 2 herpes simplex virus in immunosuppressed hamsters, Jpn. J. Exp. Med. 48:437–443.

    PubMed  CAS  Google Scholar 

  117. Kurtz, J. B., 1974, Specific IgG and IgM antibody responses in herpes simplex infections, J. Med. Microbiol. 7:333–341.

    Article  PubMed  CAS  Google Scholar 

  118. Larson, C. L., Ushijima, R. N., and Karen, R., 1972, Herpesvirus hominis type 2 infection in rabbits: Effect of prior immunization with attenuated Mycobacterium bovis (BCG), Infect. Immun. 6: 465–468.

    PubMed  CAS  Google Scholar 

  119. Lausch, R. N., Sawyers, J. S., and Kaufman, H. E., 1966, Delayed hypersensitivity to herpes simplex virus in the guinea pig, J. Immunol. 96:981–987.

    PubMed  CAS  Google Scholar 

  120. Lawman, M. J. B., Rouse, B. T., and Courtney, R. J., 1980, Cell mediated immunity against herpes simplex induction of cytotoxic T lymphocytes. Infect. Immun. 27:133–139.

    PubMed  CAS  Google Scholar 

  121. Lerner, A. M., Shippey, M. J., and Crane, L. R., 1974, Serologic responses to herpes simplex virus in rabbits: Complement-requiring neutralizing, conventional neutralizing, and passive hemagglutinating antibodies, J. Infect. Dis. 129:623–636.

    Article  PubMed  CAS  Google Scholar 

  122. Linnemann, C. C., May, D. B., Schubert, W. K., Caraway, C. T., and Schiff, G. M., 1973, Fatal viral encephalitis in children with x-linked hypogammaglobulinemia, Am. J. Dis. Child, 126: 100–103.

    PubMed  Google Scholar 

  123. Lodmell, D. L., Niwa, A., Hayashi, K., and Notkins, A. L., 1973, Prevention of cell-to-cell spread of herpes simplex virus by leukocytes, J. Exp. Med. 137:706–720.

    Article  PubMed  CAS  Google Scholar 

  124. Lodmell, D. L., and Notkins, A. L., 1974, Cellular immunity to herpes simplex virus mediated by interferon, J. Exp. Med. 140:764–778.

    Article  PubMed  CAS  Google Scholar 

  125. London, W. T., Catalano, L. W., Nahmias, A. J., Fuccillo, D. A., and Sever, J. L., 1971, Genital herpesvirus type 2 infection of monkeys, Obstet. Gynecol. 37:501–509.

    PubMed  CAS  Google Scholar 

  126. Lopez, C., 1975, Genetics of natural resistance to herpesvirus infections in mice. Nature (London) 258:152–153.

    Article  CAS  Google Scholar 

  127. Lopez, C., 1978, Genetic resistance to HSV-1 in the mouse is mediated by the “M” cell of allogeneic resistance. Fed. Proc. 37:1560.

    Google Scholar 

  128. Lopez, C., and Dudas, G., 1979, Replication of herpes simplex virus type 2 in macrophages from resistant and susceptible mice. Infect. Immun. 23:432–437.

    PubMed  CAS  Google Scholar 

  129. Lopez, C., and O’Reilly, R. J., 1977, Cell-mediated immune responses in recurrent herpesvirus infections. I. Lymphocyte proliferation assay, J. Immunol. 118:895–902.

    PubMed  CAS  Google Scholar 

  130. Luyet, F., Samra, D., Soneji, A., and Marks, M. I., 1975, Passive immunization in experimental herpesvirus hominis infection of newborn mice. Infect. Immun. 12:1258–1261.

    PubMed  CAS  Google Scholar 

  131. McClung, H., Seth, P., and Rawls, W. E., 1976, Relative concentrations in human sera of antibodies to cross-reacting and specific antigens of herpes simplex virus types 1 and 2, Am. J. Epidemiol. 104:192–201.

    PubMed  CAS  Google Scholar 

  132. McDougall, J. K., Galloway, D. A., and Fenoghio, C. M., 1980, Cervical carcinoma: Detection of herpes simplex virus RNA in cells undergoing neoplastic changes. Int. J. Cancer 25:1–8.

    Article  PubMed  CAS  Google Scholar 

  133. McKendell, R. R., Klassen, T., and Baringer, J. R., 1979, Host defenses in herpes simplex infections of the nervous system: Effect of antibody on disease and viral spread, Infect. Immun. 23:305–311.

    Google Scholar 

  134. Melewicz, F. M., Shore, S. L., Ades, E. W., and Philllips, D. J., 1977, The mononuclear cell in human blood which mediates antibody-dependent cellular cytotoxicity to virus-infected target cells. II. Identification as a K cell, J. Immunol. 118:567–573.

    PubMed  CAS  Google Scholar 

  135. Metcalf, J. F., Hamilton, D. S., and Reichert, R. W., 1979, Herpetic keratitis in athymic (nude) mice. Infect. Immun. 26:1164–1171.

    PubMed  CAS  Google Scholar 

  136. Meyers, R., 1976, Immunology of herpes simplex. Survey Ophthalm. 21:194–204.

    Article  CAS  Google Scholar 

  137. Meyers, R. L., and Pettit, J. H., 1973, The pathogenesis of corneal inflammation due to herpes simplex virus. I. Corneal hypersensitivity to HSV antigens in the rabbit, J. Immunol. 111:1031–1042.

    PubMed  CAS  Google Scholar 

  138. Milgrom, H., and Shore, S. L., 1977, Assessment of monocyte function in the normal newborn infant by antibody-dependent cellular cytotoxicity, J. Pediatr. 91:612–614.

    Article  PubMed  CAS  Google Scholar 

  139. Miller, M. E., and Stiehm, E. R. (eds.), 1979, Symposium on host defenses in the fetus and neonate. Pediatrics 64(Suppl.):705–833.

    Google Scholar 

  140. Mills, B. J., and Cooper, N. R., 1978, Antibody-independent neutralization of vesicular stomatitis virus by human complement. I. Complement requirements, J. Immunol. 121:1549–1557.

    PubMed  CAS  Google Scholar 

  141. Mintz, L., Drew, W. L., Hoo, R., and Finley, T. R.,1978, Growth of herpes simplex virus in human alveolar macrophages (abstract). Annual Meeting of the American Society for Microbiology, p. 253.

    Google Scholar 

  142. Mochizuki, D., Hedrick, S., Watson, J., and Kingsbury, D. T., 1977, The interaction of herpes simplex virus with murine lymphocytes. 1. Mitogenic properties of herpes simplex virus, J. Exp. Med. 146:1500–1510.

    Article  PubMed  CAS  Google Scholar 

  143. Mogensen, S. C., 1977, Genetics of macrophage-controlled resistance to hepatitis induced by herpes simplex virus type 2 in mice, Infect. Immun. 17:268–273.

    PubMed  CAS  Google Scholar 

  144. Mogensen, S. C., 1978, Macrophages and age-dependent resistance to hepatitis induced by herpes simplex virus type 2 in mice. Infect. Immun. 19:46–50.

    PubMed  CAS  Google Scholar 

  145. Mogensen, S. C., and Anderson, H. K., 1977, Effect of silica on the pathogenic distinction between herpes simplex virus type 1 and 2 hepatitis in mice. Infect. Immun. 17:274–277.

    PubMed  CAS  Google Scholar 

  146. Mogensen, S. C., and Anderson, H. K., 1978, Role of activated macrophages in resistance of congenitally athymic nude mice to hepatitis induced by herpes simplex virus type 2, Infect. Immun. 19:792–798.

    PubMed  CAS  Google Scholar 

  147. Møller-Larsen, A., Haahr, S., and Black, F. T., 1978, Cellular and humoral immune responses to herpes simplex virus during and after primary gingivostomatitis, Infect. Immun. 22:445–457.

    PubMed  Google Scholar 

  148. Møller-Larsen, A., Heron, I., and Haahr, S., 1977, Cell-mediated cytotoxicity to herpes-infected cells in humans: Dependence on antibodies. Infect. Immun. 16:43–47.

    PubMed  Google Scholar 

  149. Morahan, P. S., Breinig, M. C., and McGeorge, M. B., 1977, Immune responses to vaginal or systemic infection of BALB/c mice with herpes simplex virus type 2, J. Immunol. 119:2030–2036.

    PubMed  CAS  Google Scholar 

  150. Morahan, P. S., Glasgow, L. A., Crane, J. L., Jr., and Kern, E. R., 1977, Comparison of antiviral and antitumor activity of activated macrophages. Cell. Immunol. 28:404–415.

    Article  PubMed  CAS  Google Scholar 

  151. Morahan, P. S., Morse, S. B., McGeorge, M. B., 1979, Macrophage extrinsic antiviral activity during herpes simplex virus infection, J. Gen. Virol. 46:291–300.

    Article  Google Scholar 

  152. Morahan, P. S., Kern, E. R., and Glasgow, L. A., 1977, Immunomodulator-induced resistance against herpes simplex virus, Proc. Soc. Exp. Biol. Med. 154:615–620.

    PubMed  CAS  Google Scholar 

  153. Mori, R., Tasaki, T., Kimura, G., and Takeya, K., 1967, Depression of acquired resistance against herpes simplex virus infection in neonatally thymectomized mice. Arch. Ges. Virusforsch. 2: 459–462.

    Article  Google Scholar 

  154. Muller, S. A., Herrmann, E. C., and Winkelmann, R. K., 1972, Herpes simplex infection sin hematologic malignancies. Am. J. Med. 52:102–114.

    Article  PubMed  CAS  Google Scholar 

  155. Nahmias, A., 1974, The evolution (evovirology) of herpesviruses, in: Viruses, Evolution and Cancer (E. Kurstak and K. Maramorosch, eds.), pp. 605–622, Academic Press, New York.

    Google Scholar 

  156. Nahmias, A., 1977, The laboratory diagnosis of herpes simplex virus infections — Prospects and problems, Diag. Horizons 1:1–7.

    Google Scholar 

  157. Nahmias, A. J., and Ashman, R. B., 1978, The immunology of primary and recurrent herpesvirus infection—An overview, in:Oncogenesis and Herpesviruses III (G. deThé and F. Rapp, eds.). pp. 659–674, International Agency for Research on Cancer, Lyon, France.

    Google Scholar 

  158. Nahmias, A. J., and Ashman, R. B., 1979, Herpes simplex virus-associated antigens, in: Immunodiagnosis of Cancer, Part II (R. Herberman and K. R. Mclntire, eds.), pp. 857–874, Dekker, New York.

    Google Scholar 

  159. Nahmias, A., and Dowdle, W., 1968, Antigenic and biologic differences in herpesvirus hominis. Prog. Med. Virol. 10:119–159.

    Google Scholar 

  160. Nahmias, A. J., and Josey, W. E., 1981, Epidemiology of herpes simplex virus 1 and 2, in:Viral Infections of Humans: Epidemiology and Control (A. Evans, ed.). Plenum Medical, New York, (in press).

    Google Scholar 

  161. Nahmias, A., and Norrild, B., 1979, Herpes simplex viruses 1 and 2—Basic and clinical aspects, Disease-a-Month 25(10):5–49.

    Article  Google Scholar 

  162. Nahmias, A., and Norrild, B., 1980, The oncogenic potential of herpes simplex viruses and their association with cervical neoplasia, in: Oncogenic Herpesviruses (F. Rapp, ed.), CRC Press, Boca Raton pp. 25–46.

    Google Scholar 

  163. Nahmias, A., and Roizman, B., 1973, Herpes simplex viruses, N. Engl. J. Med. 289:667–674; 719–725.

    Article  PubMed  CAS  Google Scholar 

  164. Nahmias, A., and Starr, S., 1977, Infections caused by herpes simplex virus, in: Infectious Diseases (P. Hoeprich, ed.), pp. 726–735, Harper & Row, New York.

    Google Scholar 

  165. Nahmias, A., and Visintine, A., 1976, Herpes simplex, in: Infectious Diseases of the Fetus and Newhorn Infant (J. Remington and J. Klein, eds.), pp. 156–190, Saunders, Philadelphia, Pennsylvania.

    Google Scholar 

  166. Nahmias, A., and Visintine, A., 1979, Liver involve ment in neonatal herpes simplex virus infection, in:Neonatal Hepatitis and Biliary Atresia (N. Javitt, ed.), DHEW Publication No. (NIH) 79–1296, pp. 47–54.

    Google Scholar 

  167. Nahmias, A., and Whitley, R., 1981, Herpes simplex virus encephalitis in newborns and children, Ped. Rev. 2:259–266.

    Article  Google Scholar 

  168. Nahmias, A. J., Kibrick, S., and Rosan, R. C., 1964, Viral leukocyte interrelationships. I. Multiplication of a DNA virus—herpes simplex — in human leukocyte cultures, J. Immunol. 93:69–74.

    Google Scholar 

  169. Nahmias, A. J., Naib, Z. M., Josey, W. E., and Clepper, A. C., 1967, Herpes simplex infection of the female genital tract: Virological and cytological studies. Obstet. Gynecol. 29:395–400.

    PubMed  CAS  Google Scholar 

  170. Nahmias, A. J., Dowdle, W. R., Naib, Z. M., Josey, W. E., Painter, L., and Luce, C., 1969, Newborn infection with Herpesvirus hominis types 1 and 2, J. Pediat. 75:1194–1203.

    Article  PubMed  CAS  Google Scholar 

  171. Nahmias, A. J., Hirsch, M. S., Kramer, J. H., and Murphy, F. A., 1969, Effect of antithymocyte serum on herpesvirus hominis (type 2) infection in aduh mice, Proc. Soc. Exp. Biol. Med. 132:696–698.

    PubMed  CAS  Google Scholar 

  172. Nahmias, A. J., Josey, W. E., Naib, Z. M., Luce, C. P., and Duffey, A., 1970, Antibodies to herpesvirus hominis types 1 and 2 in humans. I. Patients with genital herpetic infections, Am. J. Epidemiol. 91:539–552.

    PubMed  CAS  Google Scholar 

  173. Nahmias, A., Naib, Z., and Josey, W., 1974, Epidemiological studies relating genital herpes to cervical cancer, Cancer Res. 34:1111–1117.

    PubMed  CAS  Google Scholar 

  174. Nahmias, A., Ibrahim, I., and Del Buono, I., 1975, Antigenic relationship between herpes simplex viruses, human cervical cancer and HSV-associated hamster tumors, in: Oncogenesis and Herpesviruses II (G. deThé, M. Epstein, and H. Zur Hausen, eds.), pp. 309–313, International Agency for Research on Cancer, Scientific Publications No. 11, Lyon, France.

    Google Scholar 

  175. Nahmias, A., Norrild, B., Vestergaard, B., Muther, J., Naib, Z., and Josey, W., 1978, Does HSV-1 prevent HSV-2 associated cervical neoplasia as turkey HV does MDV tumors? Abstract, 4th International Congress for Virology, The Hague, The Netherlands (Sept. 1978).

    Google Scholar 

  176. Nahmias, A., Whitley, R., Visintine, A., Dannenbarger, J., Wickliffe, C., and Alford, C., 1981, Laboratory aspects of neonatal herpes simplex virus infections (submitted for publication).

    Google Scholar 

  177. Nakamura, Y., Costa, J., Tralka, T. S., Yee, C. L., and Rabson, A. S., 1978, Properties of the cell surface Fc-receptor induced by herpes simplex virus, J. Immunol. 121:1128–1131.

    PubMed  CAS  Google Scholar 

  178. Naraqui, S., Jackson, G. G., and Jonasson, O. M., 1976, Viremia with herpes simplex type 1 in adults—four non-fatal cases, one with features of chickenpox, Ann. Int. Med. 85:165–169.

    Google Scholar 

  179. Naraqui, S., Jonasson, O., Jackson, G. G., and Yamashiroya, H. M., 1978, Clinical manifestations of infections with herpesviruses after kidney transplantation: A prospective study of various syndromes, Ann. Surg. 188:234–239.

    Article  Google Scholar 

  180. Neff, J. M., and Lane, J. M., 1970, Vaccinia necrosum following smallpox vaccination for chronic herpetic ulcers, J. Am. Med. Assoc. 213:123–125.

    Article  CAS  Google Scholar 

  181. Norrild, B., Shore, S. L., and Nahmias, A. J., 1979, Herpes simplex virus glycoproteins: Participation of individual herpes simplex virus type 1 glycoprotein antigens in immunocytolysis and their correlation with previously identified glycopolypeptides, J. Virol. 32:741–748.

    PubMed  CAS  Google Scholar 

  182. Notkins, A. L., 1971, Infectious virus antibody complexes: Interaction with anti-immunoglobulins, complement, and rheumatoid factor, J. Exp. Med. 134:419–519.

    Google Scholar 

  183. Notkins, A. L., 1974, Immune mechanisms by which the spread of viral infections is stopped, Cell. Immunol. 11:478–483.

    Article  PubMed  CAS  Google Scholar 

  184. Notter, M. F. D., and Docherty, J. J., 1976, Comparative diagnostic aspects of herpes simplex tumor-associated antigens, J. Natl. Cancer Inst. 57:483–488.

    PubMed  CAS  Google Scholar 

  185. Oakes, J. E., 1975, Role for cell-mediated immunity in the resistance of mice to subcutaneous herpes simplex virus infection. Infect. Immun. 12:166–172.

    PubMed  CAS  Google Scholar 

  186. Oakes, J. E., and Rosemond-Hornbeak, H., 1978, Antibody-mediated recovery from subcutaneous herpes simplex virus type 2 infection. Infect. Immun. 21:489–495.

    PubMed  CAS  Google Scholar 

  187. Oleske, J. M., Ashman, R. B., Kohl, S., Shore, S. L., Starr, S. E., Wood, P. A., and Nahmias, A. J., 1977, Human polymorphonuclear leukocytes as mediators of antibody-dependent cellular cytotoxicity to herpes simple virus-infected cells, Clin. Exp. Immunol. 27:446–453.

    PubMed  CAS  Google Scholar 

  188. Oleske, J. M., Starr, S. E., Kohl, S., and Nahmias, A. J., 1978, Clinical evaluation of transfer factor in patients with recurrent herpes simplex virus infections, in: Current Chemotherapy Proceedings of the 10th International Congress of Chemotherapy, Vol. 1, pp. 359–360, American Society for Microbiology, Washington, D.C.

    Google Scholar 

  189. Olson, G. B., 1973, Effect of various viruses on the responsiveness of mouse lymphocytes to phytohemagglutinin stimulation. Infect. Immun. 7: 438–444.

    CAS  Google Scholar 

  190. O’Reilly, R. J., Chibbaro, A., Anger, E., and Lopez, C., 1977, Cell-mediated immune responses in patients with recurrent herpes simplex infections. II. Infection-associated deficiency of lymphokine production in patients with recurrent herpes labialis or herpes progenitalis, J. Immunol. 118: 1095–1102.

    PubMed  Google Scholar 

  191. Pacsa, A. S., Kummerlander, L., Pejtsik, B., Krommer, K., and Pali, K., 1976, Herpes simplex virus- specific antigens in exfoliated cervical cells from women with and without cervical anaplasia. Cancer Res. 36:2130–2132.

    PubMed  CAS  Google Scholar 

  192. Para, M. F., Baucke, R. B., and Spear, P. G., 1980, Immunoglobulin G (Fc)-binding receptors on virions of HSV type 1 and transfer of these receptors to the cell surface by infection, J. Virol. 34:512–520.

    PubMed  CAS  Google Scholar 

  193. Pass, R. F., Whitley, R. J., Whelchel, J. D., Diethelm, A. G., Reynolds, D. W., and Alford, C. A., 1980, Identification of renal transplant patients with increased risk of postoperative herpes simplex virus infection, J. Infect. Dis. 140:487–492.

    Article  Google Scholar 

  194. Pavan, P. R., and Ennis, F. A., 1977, The elimination of herpes simplex plaques by antibody and the emergence of resistant strains, J. Immunol. 118:2167–2175.

    PubMed  CAS  Google Scholar 

  195. Pazin, G. J., Armstrong, J. A., Lam, M. T., Tarr, G. C., and Jannetta, P. J., and Ho, M., 1979, Prevention of reactivated herpes simplex infection by human leukocyte interferon after operation on the trigeminal root, N. Engl. J. Med. 301:205–209.

    Article  Google Scholar 

  196. Peck, B., personal communication.

    Google Scholar 

  197. Pelton, B. K., Imrie, R. C., and Denman, A. M., 1977, Susceptibility of human lymphocyte populations to infection by herpes simplex virus, Immunology 32:803–810.

    PubMed  CAS  Google Scholar 

  198. Pereira, L., Cassai, E., Honess, R., Roizman, B., Terni, M., and Nahmias, A., 1976, Variability in the structural polypeptides of herpes simplex virus strains: Potential application in molecular epidemiology, Infect. Immun. 13:211–220.

    PubMed  CAS  Google Scholar 

  199. Perrin, L. H., Joseph, B. S., Cooper, N. R., and Oldstone, M. B. A., 1976, Mechanism of injury of virus-infected cells by antiviral antibody and complement: Participation of IgG, F(ab′)2, and the alternative complement pathway, J. Exp. Med. 143:1027–1041.

    Article  PubMed  CAS  Google Scholar 

  200. Pfizenmaier, K., Jung, H., Starzinski-Powitz, A., Rollinghoff, M., and Wagner, H., 1977, The role of T cells in anti-herpes simplex virus immunity. I. Induction of antigen-specific cytotoxic T lymphocytes, J. Immunol. 119:939–944.

    PubMed  CAS  Google Scholar 

  201. Piontek, G. E., Weltzin, R., and Tompkins, W. A. F., 1980, Enhanced cytotoxicity of mouse natural killer cells for vaccinia and herpes virus-infected targets, J. Reticuloendothel. Soc. 27:175–188.

    PubMed  CAS  Google Scholar 

  202. Plaeger-Marshall, S., and Smith, J. W., 1978, Experimental infection of subpopulations of human peripheral blood leukocytes by herpes simplex virus, Proc. Soc. Exp. Biol. Med. 158:263–268.

    PubMed  CAS  Google Scholar 

  203. Pollikoff, R., Cannavale, P., and Dixon, P., 1972, Herpes simplex virus infection in rabbit eye. Arch. Ophthal. 88:52–57.

    Article  PubMed  CAS  Google Scholar 

  204. Price, R., Chernick, N. L., Horta-Barbosa, L., and Posner, J. B., 1973, Herpes simplex encephalitis in an anergic patient. Am. J. Med. 54:222–228.

    Article  PubMed  CAS  Google Scholar 

  205. Price, W., and Schmitz, J., 1979, Route of infection, systemic host resistance, and integrity of ganglionic axons influence acute and latent herpes simplex virus infection of the superior cervical ganglion, Infect. Immun. 23:373–383.

    PubMed  CAS  Google Scholar 

  206. Rabson, A. R., Whiting, D. A., Anderson, R., Glover, A., and Koornhof, H. J., 1977, Depressed neutrophil motility in patients with recurrent herpes simplex virus infections:In vitro restoration with levamisole, J. Infect. Dis. 135:113–116.

    Article  PubMed  CAS  Google Scholar 

  207. Rager-Zisman, B., and Allison, A. C., 1976, Mechanism of immunologic resistance to herpes simplex virus 1 (HSV-1) infection, J. Immunol. 116: 35–40.

    PubMed  CAS  Google Scholar 

  208. Rager-Zisman, B., and Bloom, B. R., 1974, Immunological destruction of herpes simplex virus 1 infected cells, Nature (London) 251:542–543.

    Article  CAS  Google Scholar 

  209. Ramsey, P. G., Corey, L., and Meyers, J. D., 1979, Pathogenesis of HSV-1 and HSV-2 pneumonia- Relationship to virus type (abstract #40), 19th Interscience Conference on Antimicrobial Agents and Chemotherapy, Oct. 15, 1979.

    Google Scholar 

  210. Ramshaw, I., 1975, Lysis of herpes virus-infected target cells by immune spleen cells, Infect. Immun. 11:767–769.

    PubMed  CAS  Google Scholar 

  211. Rand, K. H., Rasmussen, L. E., Pollard, R. B., Arvin, A., and Merigan, T. C., 1976, Cellular immunity and herpesvirus infections in cardiac-transplant patients, N. Engl. J. Med. 296:1372–1377.

    Article  Google Scholar 

  212. Rapp, F., and Reed, C., 1976, Experimental evidence for the oncogenic potential of herpes simplex virus. Cancer Res. 36:800–806.

    PubMed  CAS  Google Scholar 

  213. Rasmussen, A. F., and Schmidt, J. R., 1960, The influence of environmental temperature on the course of experimental herpes simplex infection, J. Infect. Dis. 106:356.

    Google Scholar 

  214. Rasmussen, L. E., Jordan, G. W., Stevens, D. A., and Merigan, T. C., 1974, Lymphocyte interferon production and transformation after herpes simplex infections in humans, J. Immunol. 112:728–736.

    PubMed  CAS  Google Scholar 

  215. Rasmussen, L. E., and Merigan, T. C., 1978, Role of T lymphocytes in cellular immune responses during herpes simplex virus infection in humans, Proc. Natl. Acad. Sci. USA 75:3957–3961.

    Article  PubMed  CAS  Google Scholar 

  216. Rawls, W. E., Bacchetti, S., and Graham, F. L., 1977, Relation of herpes simplex to human malignancy, in: Current Topics in Microbiology and Immunology (W. Arber, W. Henle, and P. H. Hofschneider, eds.), pp. 71–95, Springer-Verlag, Berlin.

    Chapter  Google Scholar 

  217. Rawls, W. E., and Tompkins, W. A. F., 1975, Destruction of virus-infected cells by antibody and complement, in: Viral Immunology and Immunopathology, (A. L. Notkins, ed.), pp. 99–111, Academic Press, New York.

    Google Scholar 

  218. Reeves, W. C., Corey, L., Vontver, L., and Adams, H., 1979, HSV type—A determinant of recurrent genital herpes (Abstract #38), 19th Interscience Conference on Antimicrobial Agents and Chemotherapy, Oct. 15, 1979.

    Google Scholar 

  219. Reichman, R. C., Dolin, R., Vincent, M. M., and Fauci, A. S., 1977, Cell-mediated cytotoxicity in recurrent herpes simplex virus infections in man, Proc. Soc. Exp. Biol. Med. 155:571–576.

    PubMed  CAS  Google Scholar 

  220. Rinaldo, C. R., Jr., Richter, B. S., Black, P. H., Callery, R., Chess, L., and Hirsch, M. S., 1978, Replication of herpes simplex virus and cytomegalovirus in human leukocytes, J. Immunol. 120:130–136.

    PubMed  Google Scholar 

  221. Roane, P. R., Jr., and Roizman, B., 1964, Studies of the determinant antigens of viable cells. II. Demonstration of altered antigenic reactivity of HEp-2 cells infected with herpes simplex virus. Virology 22:1–8.

    Article  Google Scholar 

  222. Rogers, H. W., Scott, L. V., and Patnode, R. A., 1972, Sensitization of guinea pigs to herpes simplex virus, J. Immunol. 109:801–806.

    PubMed  CAS  Google Scholar 

  223. Roizman, B., 1965, An inquiry into the mechanisms of recurrent herpetic infections of man, Persp. Virol. 4:283–301.

    Google Scholar 

  224. Roizman, B., 1979, The structure and isomerization of the herpes simplex viruses. Cell 16:481–502.

    Article  PubMed  CAS  Google Scholar 

  225. Romano, T. J., and Shore, S.L., 1977, Lysis of virus-infected target cells by antibody dependent cellular cytotoxicity. 1. General requirements of the reaction and temporal relationship between lethal hits and cytolysis. Cell. Immunol. 30:66–81.

    Article  PubMed  CAS  Google Scholar 

  226. Romano, T. J., and Shore, S. L., 1979, Analysis of the adhesion step in the herpes simplex virus antibody-dependent cellular cytotoxicity system. Infect. Immun. 26:163–172.

    PubMed  CAS  Google Scholar 

  227. Rosenberg, G. L., and Notkins, A. L., 1974, Induction of cellular immunity to herpes simplex virus: Relationship to the humoral immune response, J. Immunol. 112:1019–1024.

    PubMed  CAS  Google Scholar 

  228. Rosenberg, G. L., Farber, P. A., and Notkins, A. L., 1972, In vitro stimulation of sensitized lymphocytes by herpes simplex virus and vacinia virus, Proc. Natl. Acad. Sci. USA 69:756–760.

    Article  PubMed  CAS  Google Scholar 

  229. Rosenberg, G. L., Wohlenberg, C., Nahmias, A. J., and Notkins, A. L., 1972, Differentiation of type 1 and type 2 herpes simplex virus by in vitro stimulation immune lymphocytes, J. Immunol. 109:413–414.

    PubMed  CAS  Google Scholar 

  230. Rosenberg, G. L., Snyderman, R., and Notkins, A. L., 1974, Production of chemotactic factor and lymphotoxin by human leukocytes stimulated with herpes simplex virus. Infect. Immun. 10:111–115.

    PubMed  CAS  Google Scholar 

  231. Rosenthal, J., Hayashi, K., and Notkins, A. L., 1973, Virus antigens on the surface of infected cells: Binding and elution of 125I-labelled antivirus antibody, J. Gen. Virol. 18:195–199.

    Article  PubMed  CAS  Google Scholar 

  232. Rouse, B. T., Grewal, A. S., Babiuk, L. A., and Fujimiya, Y., 1977, Enhancement of antibody-dependent cell-mediated cytotoxicity of herpesvirus-infected cells by complement. Infect. Immun. 18:660–665.

    PubMed  CAS  Google Scholar 

  233. Royston, I., and Aurelian, L., 1970, Immunofluorescent detection of herpesvirus antigens in exfoliated cells from human cervical carcinoma, Proc. Natl. Acad. Sci. USA 67:204–217.

    Article  PubMed  CAS  Google Scholar 

  234. Rudneva, A., Korabelhikora, N. I., Germanov, A. B., Sokolov, M. I., and Fadeeva, L. I., 1972, Studies of interferogenic activity of herpes simplex virus. Arch. Virusforsch. 37:1–5.

    Article  PubMed  CAS  Google Scholar 

  235. Russell, A. S., 1974, Cell-mediated immunity to herpes simplex virus in man, J. Infect. Dis. 129:142–146.

    Article  PubMed  CAS  Google Scholar 

  236. Russell, A. S., and Essery, G., 1977, Cellular immunity to herpes simplex virus in man. VII. K-cell activity to HSV-1 infected target cells in disease. Cancer 40: 42–45.

    Article  PubMed  CAS  Google Scholar 

  237. Russell, A. S., and Kaiser, J. T., 1976, Cell-mediated immunity to herpes simplex virus in man. V. Antibody-mediated cell-dependent immune lysis of herpes virus-infected target cells, J. Allergy Clin. Immunol. 58:539–545.

    Article  PubMed  CAS  Google Scholar 

  238. Russell, A. S., and Miller, C., 1978, A possible role for polymorphonuclear leukocytes in the defense against recrudescent herpes simplex virus infection in man. Immunology 4:371–378.

    Google Scholar 

  239. Russell, A. S., and Schlaut, J., 1977, Association of HLA-Al antigen and susceptibility to recurrent cold sores. Arch. Dermatol. 113:1721–1722.

    Article  PubMed  CAS  Google Scholar 

  240. Russell, A. S., Percy, J. S., and Kovithavongs, T., 1975, Cell-mediated immunity to herpes simplex in humans: Lymphocyte cytotoxicity measured by 51Cr release from infected cells. Infect. Immun. 11:355–359.

    PubMed  CAS  Google Scholar 

  241. Russell, A. S., Kaiser, J., Lao, V. S., 1976, Cell-mediated immunity to herpes simplex in man. IV. A correlation of lymphocyte stimulation and inhibition of leukocyte migration, J. Immunol. Meth. 9:273–279.

    Article  CAS  Google Scholar 

  242. Saksela, E., Leinikki, P., and Vesterinen, E., 1976, Adenine arabinoside (Ara-A) blocked HSV-2 infected human skin fibroblasts as targets for the detection of serum-mediated and cellular cytotoxicity in patients with cervical carcinoma, Clin. Exp. Immunol. 25:264–269.

    Google Scholar 

  243. Santoli, D., Trinchieri, G., and Koprowski, H., 1978, Cell-mediated cytotoxicity against virus-infected target cells in humans. II. Interferon induction and activation of natural killer cells, J. Immunol. 121:532–538.

    PubMed  CAS  Google Scholar 

  244. Santoli, D., Trinchieri, G., and Lief, F. S., 1978, Cell-mediated cytotoxicity against virus-infected target cells in humans. I. Characterization of the effector lymphocyte, J. Immunol. 121:526–538.

    PubMed  CAS  Google Scholar 

  245. Schlabach, A. J., Martinez, D., Field, A. K., and Tytell, A. A., 1979, Resistance of C58 mice to primary systemic herpes simplex virus infection: Macrophage dependence and T-cell independence. Infect. Immun. 26:615–620.

    PubMed  CAS  Google Scholar 

  246. Schlehofer, J. R., Habermehl, K.-O., Diefenthal, W., and Hampl, H., 1979, Reduction of 51Cr- permeability of tissue culture cells by infection with herpes simplex virus type 1, Intervirology 11:158–166.

    Article  PubMed  CAS  Google Scholar 

  247. Schräder, J. W., and Edelman, G. M., 1977, Joint recognition by cytotoxic T cells of inactivated Sendai virus and products of the major histocompatability complex, J. Exp. Med. 145:523–539.

    Article  PubMed  Google Scholar 

  248. Scriba, M., 1974, Stimulation of peripheral blood lymphocytes by herpes simplex virus in vitro, Infect. Immun. 10:430–436.

    PubMed  CAS  Google Scholar 

  249. Scriba, M., 1975, Herpes simplex virus infection in guinea pigs: an animal model for studying latent and recurrent herpes simplex virus infection. Infect. Immun. 12:162–165.

    PubMed  CAS  Google Scholar 

  250. Scriba, M., 1977, Extraneural localisation of herpes simplex virus in latently infected guinea pigs. Nature (London) 1267:529–531.

    Article  Google Scholar 

  251. Scriba, M., 1978, Animal studies on the efficacy of an inactivated herpes simplex virus vaccine against recurrent herpes infections. Infection 6:137–139.

    Article  PubMed  CAS  Google Scholar 

  252. Sethi, K. K., and Brandis, H., 1977, Specifically immune mouse T-cells can destroy H-1 compatible murine target cells infected with herpes simplex virus types 1 and 2, Z. Immun.-Forsch. 150:162–173.

    Google Scholar 

  253. Sethi, K. K., and Brandis, H., 1978, Interferon enhances T cell mediated cytotoxicity of H-2 compatible target cells infected with UV-inactivated herpes simplex virus. Arch. Virol. 57:177–183.

    Article  PubMed  CAS  Google Scholar 

  254. Shelley, W. B., 1967, Herpes simplex virus as a cause of erythema multiforme, J. Am. Med. Assoc. 201:153–156.

    Article  Google Scholar 

  255. Shillitoe, E. J., Wilton, J. M. A., and Lehner, T., 1977, Sequential changes in cell-mediated immune responses to herpes simplex virus after recurrent herpetic infection in humans. Infect. Immun. 18:130–137.

    PubMed  CAS  Google Scholar 

  256. Shillitoe, E. J., Wilton, J. M. A., and Lehner, T., 1978, Sequential changes in T and B lymphocyte responses to herpes simplex virus in man, Scand. J. Immunol. 7:357–366.

    Article  PubMed  CAS  Google Scholar 

  257. Shimizu, F., Hanaumi, K., Shimizu, Y., and Kumagai, K., 1977, Antibody-dependent cellular protection against herpes simplex virus dissemination as revealed by viral plaque and infective assays, Infect. Immun. 16:531–536.

    PubMed  CAS  Google Scholar 

  258. Shore, S. L., and Romano, T. J., 1980, Analysis of the lytic step in the herpes simplex virus antibody-dependent cellular cytotoxicity system. Infect. Immun. 28:137–146.

    PubMed  CAS  Google Scholar 

  259. Shore, S. L., Cromeans, T. L., and McDougal, J. S., 1979, Lysis of herpes-infected cells early in the infectious cycle by antibody and complement (abstract), Annual Meeting American Society of Microbiology, p. 80.

    Google Scholar 

  260. Shore, S. L., Nahmias, A. J., Starr, S. E., Wood, P. A., and McFarlin, D. E., 1974, Detection of cell-dependent cytotoxic antibody to cells infected with herpes simplex virus, Nature (London) 251:350–352.

    Article  CAS  Google Scholar 

  261. Shore, S. L., Cromeans, T. L., and Romano, T. J., 1976, Immune destruction of virus-infected cells early in the infectious cycle. Nature (London) 262:695–696.

    Article  CAS  Google Scholar 

  262. Shore, S. L., Cromeans, T. L., and Norrild, B., 1979, Early damage of herpes-infected cells by antibody-dependent cellular cytotoxicity: Relative roles of virus-specified cell surface antigens and input virus, J. Immunol. 123:2239–2244.

    PubMed  CAS  Google Scholar 

  263. Shore, S. L., Black, C. M., Melewicz, F. M., Wood, P. A., and Nahmias, A. J., 1976, Antibody-dependent cell-mediated cytotoxicity to target cells infected with type 1 and type 2 herpes simplex virus, J. Immunol. 116:194–201.

    PubMed  CAS  Google Scholar 

  264. Shore, S. L., Romano, T. J., Hubbard, M. R., and Gordon, D. S., 1977, Lysis of virus-infected target cells by antibody-dependent cellular cytotoxicity. II. Reversibility of the heat inactivation of K cell killing and relationship of Fc receptor capping to lysis, Cell. Immunol. 311:55–61.

    Article  Google Scholar 

  265. Shore, S. L., Milgrom, H., Wood, P. A., and Nahmias, A. J., 1977, Antibody-dependent cellular cytotoxicity to target cells infected with herpes simplex viruses: Functional adequacy in the neonate, Pediatrics 59:22–28.

    PubMed  CAS  Google Scholar 

  266. Shore, S. L., Melewicz, F. M., Gordon, D. S., 1977, The mononuclear cell in human blood which mediates antibody-dependent cellular cytotoxicity to virus-infected target cells. I. Identification of the population of effector cells, J. Immunol. 118:558–566.

    PubMed  CAS  Google Scholar 

  267. Shore, S. L., Cromeans, T. L., McDougal, J. S., 1979, Lysis of herpes-infected cells as the infectious cycle by antibody and complement, Abstract E(H)16, Annual Meeting of American Society for Microbiology, p. 80.

    Google Scholar 

  268. Siebens, H., Tevethia, S. S., and Babior, B. M., 1979, Neutrophil-mediated antibody-dependent killing of herpes-simplex-virus-infected cells, Blood 54:88–94.

    PubMed  CAS  Google Scholar 

  269. Simmons, R. L., Centifanto, Y., and Kaufman, H. E., 1974, Plaque size reduction as a measure of viral cell-mediated immunity, Infect. Immun. 10:1034–1039.

    PubMed  CAS  Google Scholar 

  270. Skinner, G. R. B., Mushi, E. Z., and Whitney, J. E., 1976, Immune inhibition of virus release from herpes simplex virus-infected cells, Intervirology 6:296–308.

    Article  CAS  Google Scholar 

  271. Skinner, G. R. B., Whitney, J. E., and Hartley, C., 1977, Prevalence of type-specific antibody against type 1 and type 2 herpes simplex virus in women with abnormal cervical cytology; evidence towards pre-pubertal vaccination of seronegative female subjects. Arch. Virol. 54:211.

    Article  PubMed  CAS  Google Scholar 

  272. Skinner, G. R. B., Buchan, W. A., Whitney, J., Harding, M., and Godfish, K., 1978, Preparation and efficacy of an inactivated subunit vaccine (NFU1BHK) against type 2 herpes simplex virus infection, Med. Microbiol. Immunol. 166:119–132.

    Article  PubMed  CAS  Google Scholar 

  273. Smith, J. W., Adam, E., Melnick, J. L., and Rawls, W. E., 1972, Use of the 51Cr release test to demonstrate patterns of antibody response in humans to herpesvirus types 1 and 2, J. Immunol. 109:554–564.

    PubMed  CAS  Google Scholar 

  274. Smith, J. W., Toores, J. E., and Holmquist, N. D., 1979, Association of herpes simplex virus with cervical cancer by lymphocyte reactivity with HSV-1 and HSV-2 antigens, Am. J. Epidemiol. 110:141–147.

    PubMed  CAS  Google Scholar 

  275. Sorice, F., 1971, La malattia erpetica, G. Mall. Infett. 23:469–546.

    CAS  Google Scholar 

  276. Spear, P., 1980, Composition and organization of herpesvirus virions and functions of the structural proteins, in: Oncogenic Herpesviruses (F. Rapp, ed.), CRC Press, Boca Raton VI pp. 53–84.

    Google Scholar 

  277. Spruance, S. L., Overall, J. C., Kern, E. R., Krueger, G. G., Pliam, V., and Miller, W., 1977, The natural history of recurrent herpes simplex labialis, N. Engl. J. Med. 297:69–75.

    Article  PubMed  CAS  Google Scholar 

  278. Stanwick, T., Campbell, D. E., and Nahmias, A. J., Spontaneous cytotoxicity mediated by human monocyte-macrophages against human fibroblasts infected with herpes simplex virus. Cell Immunol. 53:413–417.

    Google Scholar 

  279. Stanwick, T. L., Anderson, R. W., and Nahmias, A. J., 1977, Interaction between cyclic nucleotides and herpes simplex viruses — Productive infection. Infect. Immun. 18:342–347.

    PubMed  CAS  Google Scholar 

  280. Starr, S. E., Karatela, S. A., Shore, S. L., Duffey, A. C., and Nahmias, A. J., 1975, Stimulation of human lymphocytes by herpes simplex virus antigens, Infect. Immun. 11:109–112.

    PubMed  CAS  Google Scholar 

  281. Starr, S. E., Visintine, A. M., Tomeh, M. O., and Nahmias, A. J., 1976, Effects of immunostimulants on resistance of newborn mice to herpes simplex type 2 infection, Proc. Soc. Exp. Biol. Med. 152:57–60.

    PubMed  CAS  Google Scholar 

  282. Steele, R. W., Hensen, S. A., Vincent, M. M., Fuccillo, D. A., Chapa, I. A., and Canales, L., 1975, Cellular immune responses to herpes simplex virus type 1 in recurrent herpes labialis: In vitro blastogenesis and cytotoxicity, J. Infect. Dis. 131:528–534.

    Article  PubMed  CAS  Google Scholar 

  283. Steele, R. W., Keeney, R. E., Brown, J., and Young, J., 1977, Cellular immune responses to herpesviruses during treatment with adenine arabinoside, J. Infect. Dis. 135:593–599.

    Article  PubMed  CAS  Google Scholar 

  284. Stevens, J. G., 1975, Latent herpes simplex virus and the nervous system, Curr. Top. Microbiol. Immunol. 70:31–50.

    Article  PubMed  CAS  Google Scholar 

  285. Stevens, J. G., and Cook, M. L., 1970, Restriction of herpes simplex virus by macrophages: An analysis of the cell-virus interaction. J. Exp. Med. 133:19–38.

    Article  Google Scholar 

  286. Stevens, J. G., and Cook, M. L., 1974, Maintenance of latent herpetic infection: An apparent role for antiviral IgG, J. Immunol 113:1685–1693.

    PubMed  CAS  Google Scholar 

  287. Stewart, J., and Nahmias, A., 1981, Laboratory diagnosis of herpes simplex viruses, in:Laboratory Diagnosis of Sexually Transmitted Diseases, A.P.H.A., Washington, D.C. (in press).

    Google Scholar 

  288. Stringfellow, D. A., Kern, E. R., Kelsey, D. K., and Glasgow, L. A., 1977, Suppressed response to interferon induction in mice infected with encephalomyocarditis virus, Semliki Forest virus, influenza A2 virus. Herpesvirus hominis type 2, or murine cytomegalovirus, J. Infect. Dis. 135: 540–551.

    Article  PubMed  CAS  Google Scholar 

  289. Strnad, B. C., and Aurelian, L., 1978, Proteins of herpesvirus 2. III. Isolation and immunologic characterization of a large molecular weight viral protein, Virology 87:401–415.

    Article  PubMed  CAS  Google Scholar 

  290. Strunk, R. C., John, T. J., and Sieber, O. F., 1977, Herpes simplex virus infections in guinea pigs deficient in the fourth component of complement. Infect. Immun. 15:165–168.

    PubMed  CAS  Google Scholar 

  291. Subramanian, T., and Rawls, W. E., 1977, Compar ison of antibody-dependent cellular cytotoxicity and complement-dependent antibody lysis of herpes simplex virus-infected cells as methods of detecting antiviral antibodies in human sera, J. Clin. Microbiol. 5:551–558.

    PubMed  CAS  Google Scholar 

  292. Sydiskis, R. J., and Schultz, I., 1966, Interferon and antibody production in mice with herpes simplex skin infection. J. Infect. Dis. 116:455–460.

    Article  PubMed  CAS  Google Scholar 

  293. Symoens, J., and Rosenthal, M., 1977, Levamisole in the modulation of the immune response: The current experimental and clinical state, J. Retic. Endothel. Soc. 21:175–221.

    CAS  Google Scholar 

  294. Teissier, P., Castinel, P., and Reilly, J., 1922, L’inoculabilité de l’herpes, C.R. Soc. Biol. 87:648–649.

    Google Scholar 

  295. Tevethia, S. S., Lowry, S., Rawls, W., Melnick, J., and McMillan, V., 1972, Detection of early cell surface changes in herpes simplex virus infected cells by agglutination with concanavalin A, J. Gen. Virol. 15:93–97.

    Article  PubMed  CAS  Google Scholar 

  296. Thiry, L., Sprecher-Goldberger, S., Fassin, Y., Gould, I., Gompel, C., Pestiau, J., and DeHalleux, F., 1974, Variations of cytotoxic antibodies to cells with herpes simplex virus antigens in women with progressing or regressing cancerous lesions of the cervix. Am. J. Epidemiol. 100:251–261.

    PubMed  CAS  Google Scholar 

  297. Thiry, L., Sprecher-Goldberger, S., Hannecart-Pokorni, E., Gould, I., and Bossens, M., 1977, Specific non-immunoglobulin G antibodies and cell-mediated responses to herpes simplex virus antigens in women with cervical carcinoma. Cancer Res. 37:1301–1306.

    PubMed  CAS  Google Scholar 

  298. Thong, Y. H., Vincent, M. M., Hensen, S. A., Fuccillo, D. A., Rola-Pleszczynski, M., and Bellanti, J. A., 1975, Depressed specific cell-mediated immunity to herpes simplex virus type 1 patients with recurrent herpes labialis. Infect. Immun. 12:76–80.

    PubMed  CAS  Google Scholar 

  299. Tokamaru, T., 1966, A possible role of gamma A-immunoglobulin in herpes simplex virus infection in man, J. Immunol 97:248–259.

    Google Scholar 

  300. Tompkins, W. A. F., Seth, P., Gee, S., and Rawls, W. E., 1975, Neuraminidase reversal of resistance to lysis of herpes simplex virus-infected cells by antibody and complement, J. Immunol 116: 489–495.

    Google Scholar 

  301. Thompson, C. J., Docherty, J. J., Boltz, R. C., Gaines, R. A., and Todd, P., 1978, Electrokinetic alteration of the surface of herpes simplex virus infected cells, J. Gen. Virol. 39:449–461.

    Article  PubMed  CAS  Google Scholar 

  302. Trofatter, K. F., and Daniels, C. A., 1979, Interactions of human cells with prostaglandin cyclic AMP modulators, J. Immunol 122:1363–1370.

    PubMed  CAS  Google Scholar 

  303. Trofatter, K. F., Daniels, C. A. Williams, R. J., and Gall S.A., 1979, Growth of type 2 herpes simplex virus in newborn and adult mononuclear leukocytes, Intervirology 11:117–123.

    Article  PubMed  Google Scholar 

  304. Valle, M. J., Jordan, G. W., Haahr, S., and Merigan, T. C., 1975, Characteristics of immune interferon produced by human lymphocyte cultures compared to other human interferon, J. Immunol 115:230–233.

    PubMed  CAS  Google Scholar 

  305. Visintine, A. M., Nahmias, A. J., and Josey, W. E., 1978, Genital herpes. Perinatal Care 2:32–41.

    Google Scholar 

  306. Whitley, R. J., Nahmias, A. J., Visintine, A. M., Fleming, C. L., and Alford, C. A., 1980, The natural history of herpes simplex virus infection of mother and newborn. Pediatrics 66:495–501.

    PubMed  CAS  Google Scholar 

  307. Vos, G. H., Hammond, M. G., Vos, D., Grabbelar, B. G., Ansiander, H. P., and Marescotti, G., 1972, An evaluation of humoral antibody responses in patients with carcinoma of the cervix, J. Obstet. Gynecol. Br. Commun. 79:1040–1046.

    Article  CAS  Google Scholar 

  308. Wallis, C., and Melnick, J. L., 1971, Herpesvirus neutralization: The role of complement, J. Immunol. 107:1235–1242.

    PubMed  CAS  Google Scholar 

  309. Walz, M. A., Price, R. W., Hayashi, K., Katz, B. J., and Notkins, A. L., 1977, Effect of immunization on acute and latent infections of vaginouterine tissue with herpes simplex virus type 1 and 2, J. Infect. Dis. 135:744–752.

    Article  PubMed  CAS  Google Scholar 

  310. Walz, M. A., Yamamoto, H., and Notkins, A. L., 1976, Immunological response restricts number of cells in sensory gangha infected with herpes simplex virus. Nature (London) 264:553–556.

    Article  Google Scholar 

  311. Warren, K. G., Brown, S. M., Wroblewska, Z., Gilden, D., Koprowskin, H., and Subak-Sharpe, J., 1978, Isolation of latent herpes simplex virus from the superior cervical and vagus ganghons of human beings, N. Engl. J. Med. 298:1068.

    Article  PubMed  CAS  Google Scholar 

  312. Warren, K. G., Wroblewska, Z., Okabe, H., Brown, S. M., Gilden, D. H., Koprowski, H., Borke, B., Subak-Sharpe, J., and Yonezawa, L., 1978, Virology and histopathology of the trigeminal ganglia of Americans and Japanese, Can. J. Neurol. Sci. 5:425–430.

    PubMed  CAS  Google Scholar 

  313. Willems, F. T. C., Melnick, J. L., and Rawls, W. E., 1969, Viral inhibition of the phytohemagglutinin response of human lymphocytes and application to viral hepatitis, Proc. Soc. Exp. Biol. Med. 130:652–661.

    PubMed  CAS  Google Scholar 

  314. Wilton, J. M. A., Ivanyi, L., and Lehner, T., 1972, Cell-mediated immunity in herpesvirus hominis infections, Br. Med. J. 1:723–726.

    Article  PubMed  CAS  Google Scholar 

  315. Winter, H. A., Bryson, Y. J., Gard, S. E., Fischer, T. J., and Stiehm, E. R., 1978, Deficiency of monocyte migration inhibition factor and immune interferon production in lymphocytes of normal newborns, Pediat. Res. 12:488.

    Article  Google Scholar 

  316. Wise, T. G., Pavan, P. R., and Ennis, F. A., 1977, Herpes simplex virus vaccine, J. Infect. Dis. 136:706–711.

    Article  PubMed  CAS  Google Scholar 

  317. Wutzler, P., Farber, I., and Ulbricht, A., 1978, Autoantibodies in herpesvirus infections, Acta Virol. 22:342.

    PubMed  CAS  Google Scholar 

  318. Yamamoto, Y., 1966, A re-evaluation of the skin test of herpes simplex virus, Jpn. J. Microbiol. 10:67–77.

    PubMed  CAS  Google Scholar 

  319. Yoshino, K., Hashimoto, M., and Shinkai, K., 1977, Studies on the neutralization of herpes simplex virus. VIII. Significance of viral sensitization for inactivation by complement, Microbiol. Immunol. 21:231–241.

    PubMed  CAS  Google Scholar 

  320. Yoshino, K., and Taniguchi, S., 1964, The appearance of complement-requiring neutralizing antibodies by immunization and infection with herpes simplex virus, Virology 22:193–201.

    Article  PubMed  CAS  Google Scholar 

  321. Yoshino, K., and Taniguchi, S., 1966, Evaluation of the demonstration of complement-requiring neutralizing antibody as a means for early diagnosis of herpes virus infections, J. Immunol. 96:196–203.

    PubMed  CAS  Google Scholar 

  322. Zaia, J. A., Leary, P. L., Levin, M. J., 1978, Specificity of the blastogenic response of human mononuclear cells to herpesvirus antigens. Infect. Immun. 20:646–651.

    PubMed  CAS  Google Scholar 

  323. Zaia, J. A., Palmer, E. L., and Feorino, P., 1975, Humoral and cellular immune responses to an envelope-associated antigen of herpes simplex virus, J. Infect. Dis. 132:660–666.

    Article  PubMed  CAS  Google Scholar 

  324. Zawatzky, R., Hilfenhaus, J., and Kirchner, H., 1979, Resistance of nude mice to herpes simplex virus and correlation with in vitro production of interferon. Cell. Immunol. 47:424–428.

    Article  PubMed  CAS  Google Scholar 

  325. Zinkernagel, R. M., and Doherty, P. C., 1977, Major transplantation antigens, viruses, and specificity of surveillance T cells, Contemp. Top. Immunobiol. 7:179–220.

    Article  PubMed  CAS  Google Scholar 

  326. Zisman, B., Hirsch, S., and Allison, A. C., Selective effects of anti-macrophage serum, silica and antilymphocyte serum on pathogenesis of herpes virus infection of young adult mice, J. Immunol. 104:1155–1165.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Immunology Division, Bureau of Laboratories, Center for Disease Control, U.S. Public Health Service, 30333, Atlanta, Georgia, USA

    Steven L. Shore

  2. Infectious Disease and Immunology Division, Department of Pediatrics, Emory University School of Medicine, 30303, Atlanta, Georgia, USA

    Steven L. Shore & André J. Nahmias

Authors
  1. Steven L. Shore
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. André J. Nahmias
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Emory University, Atlanta, Georgia, USA

    André J. Nahmias

  2. Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Richard J. O’Reilly

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Publishing Corporation

About this chapter

Cite this chapter

Shore, S.L., Nahmias, A.J. (1982). Immunology of Herpes Simplex Viruses. In: Nahmias, A.J., O’Reilly, R.J. (eds) Immunology of Human Infection. Comprehensive Immunology, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1012-9_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-1012-9_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1014-3

  • Online ISBN: 978-1-4684-1012-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation