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The (Extended) Ternary Complex Model ([E]TCM) for G Protein Activation

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Signal Transduction by G Protein-Coupled Receptors

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Many reviews have been written in which the mechanism of G protein activation is described. Several authors including Birnbaumer1–3 Chabre et al,4 Conklin and Bourne,5 Gilman,6,7 Rodbell8 and Stryer9 describe in detail how G proteins may be activated by GPCRs; extensive lists of references are presented loc. cit. I this subsection we summarize the most important findings.

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Authors and Affiliations

  1. Leiden/Amsterdam Center for Drug Research, Amsterdam, The Netherlands

    Paul H. J. Nederkoorn Ph.D., Henk Timmerman Ph.D. & Gabriëlle M. Donné-Op den Kelder Ph.D.

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  1. Paul H. J. Nederkoorn Ph.D.
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  2. Henk Timmerman Ph.D.
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  3. Gabriëlle M. Donné-Op den Kelder Ph.D.
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© 1997 Springer Science+Business Media Dordrecht

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Nederkoorn, P.H.J., Timmerman, H., den Kelder, G.M.DO. (1997). The (Extended) Ternary Complex Model ([E]TCM) for G Protein Activation. In: Signal Transduction by G Protein-Coupled Receptors. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1407-3_5

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  • DOI: https://doi.org/10.1007/978-1-4684-1407-3_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1409-7

  • Online ISBN: 978-1-4684-1407-3

  • eBook Packages: Springer Book Archive

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