The Role of the Lungs in the Metabolism of Vasoactive Substances

Vane, John R.

doi:10.1007/978-1-4684-2055-5_11

John R. Vane⁵^nAff6

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Abstract

The lungs are in an excellent and strategic position for cleansing the blood, for it all passes through them several times a minute. Apart from their respiratory function (removing carbon dioxide from the pulmonary circulation), the lungs also have other important cleansing mechanisms, including phagocytosis by alveolar macrophages, the filtering of emboli and circulating leucocytes, and excretion of other volatile substances (Said, 1968; Heinemann and Fishman, 1969). Work from my laboratory in recent years has highlighted the less widely appreciated but probably equally important function of the lungs: the removal of some vasoactive hormones from blood and the synthesizing of others. This paper will bring earlier reviews up-to-date (Vane, 1968; 1969).

This review was completed in 1972.

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References

Alabaster, V. A., 1971, Ph.D. thesis. London University.
Google Scholar
Alabaster, V. A., and Bakhle, Y. S., 1970a, Brit. J. Pharmacol. 40: 468.
CAS Google Scholar
Alabaster, V. A., and Bakhle, Y. S., 1970b, Brit. J. Pharmacol. 40: 582P.
Google Scholar
Alabaster, V. A., and Bakhle, Y. S., 1972a, Brit. J. Pharmacol. 45: 299.
CAS Google Scholar
Alabaster, V. A., and Bakhle, Y. S., 1972b, Circulation Res. 31:Supp II, 72.
PubMed Google Scholar
Alabaster, V. A., and Bakhle, Y. S., 1973, Brit. J. Pharmacol. 47: 325.
CAS Google Scholar
Änggård, E., and Samuelsson, B., 1964, J. Biol. Chem. 239: 4097.
Google Scholar
Änggård, E., and Samuelsson, B., 1966, Arkiv Kemi 25: 293.
Google Scholar
Änggård, E., and Samuelsson, B., 1967, Proceedings of the 2nd Nobel Symposium Stockholm, p. 97, Interscience, New York.
Google Scholar
Bailey, T., Clements, J. A., and Osbahr, A. J., 1967, Circulation Res. 21: 469.
Google Scholar
Bakhle, Y. S., 1968, Nature (London) 220: 919.
Article CAS Google Scholar
Bakhle, Y. S., Reynard, A. M., and Vane, J. R., 1969, Nature (London) 222: 956.
Article CAS Google Scholar
Bakhle, Y. S., and Smith, T. W., 1972, Brit. J. Pharmacol. 46: 543P.
Google Scholar
Biron, P., 1968, Rev. Can. Biol. 27: 75.
PubMed CAS Google Scholar
Biron, P., and Boileau, J. C., 1969, Can. J. Physiol. Pharmacol. 47: 713.
Article PubMed CAS Google Scholar
Biron, P., and Campeau, L., 1971, Rev. Can. Biol. 30: 27.
PubMed CAS Google Scholar
Biron, P., Campeau, L., and David, P., 1969, Am. J. Cardiol. 24: 544.
Article PubMed CAS Google Scholar
Biron, P., Meyer, P., and Panisset, J. C., 1968, Can. J. Physiol. Pharmacol. 46: 175.
Article PubMed CAS Google Scholar
Boileau, J. C., Campeau, L., and Biron P., 1971, Rev. Can. Biol. 30: 281.
PubMed CAS Google Scholar
Boileau, J. C., Campeau, L., and Biron, P., 1972, Rev. Can. Biol. 31: 185.
PubMed CAS Google Scholar
Boileau, J. C., Crexells, C., and Biron, P., 1972, Rev. Can. Biol. 31: 69.
PubMed CAS Google Scholar
Born, G. V. R., 1963, in: The Scientific Basis of Medicine Ann Rev., p. 269, Athlone Press, London.
Google Scholar
Carlson, L. A., and Orö, L., 1966, Acta Physiol. Scand. 67: 89.
Article PubMed CAS Google Scholar
Crexells, C., Bourassa, M. G., and Biron, P., 1972, J. Clin. Endocrinol. 34: 592.
Article Google Scholar
Cushman, D. W., and Cheung, H. S., 1972, in: Hypertension 72 (Genest, J. and Koiw, E., ed.), p. 532, Springer-Verlag, New York.
Google Scholar
Davis, R. B., 1968, in: Advances in Pharmacology (Garattini, S., Shore, P. A., Costa, E., and Sandler, M., eds.) Vol. 6, p. 146, Academic Press, New York.
Google Scholar
Davis, R. B., and Wang, Y., 1965, Proc. Soc. Exp. Biol. Med. 118: 799.
Google Scholar
Eble, J. N., Gowdey, C. W., and Vane, J. R., 1971, Nature (London) 231: 181.
Article CAS Google Scholar
Eiseman, B., Bryant, L., and Waltuch, T., 1964, J. Thorac. Cardiovasc. Surg. 48: 798.
PubMed CAS Google Scholar
Eliseeva, Y. E., Orekhovich, V. N., Pavlikhina, L. V., and Alexeenko, L. P., 1971, Clin. Chim. Acta 31: 413.
Article CAS Google Scholar
Elliot, T. R., 1905, J. Physiol. London 32: 401.
Google Scholar
Ferreira, S. H., and Vane, J. R., 1967a, Nature (London) 215: 1237.
Article CAS Google Scholar
Ferreira, S. H., and Vane, J. R. 1967b, Brit. J. Pharmacol. 29: 367.
PubMed CAS Google Scholar
Ferreira, S. H., and Vane, J. R., 1967c, Brit. J. Pharmacol. 30: 417.
PubMed CAS Google Scholar
Ferreira, S. H., and Vane, J. R., 1967d, Nature (London) 216: 868.
Article CAS Google Scholar
Freer, R. J., and Stewart, J. M., 1972, Federation Proc. 31: 512 Abs.
Google Scholar
Gaddum, J. H., 1953, Brit. J. Pharmacol. 8: 321.
PubMed CAS Google Scholar
Gaddum, J. H., Hebb, C. O., Silver, A., and Swan, A. A. B., 1953, Quart. J. Exp. Physiol. 38: 255.
PubMed CAS Google Scholar
Gershon, M. D., and Ross, L. L., 1966a, J. Physiol. London, 186: 451.
PubMed CAS Google Scholar
Gershon, M. D., and Ross, L. L., 1966b, J. Physiol. London 186: 477.
PubMed CAS Google Scholar
Gibson, E. C., Hodge, R. L., Jackson, H. R., Katic, F. P., and Stevens, A. M., 1972, Australian Physiol. & Pharmacol. Soc.
Google Scholar
Gilmore, N. J., and Vane, J. R., 1970, Brit. J. Pharmacol. 38: 633.
CAS Google Scholar
Gillis, C. N., 1971, Experientia 27: 1317.
Article PubMed CAS Google Scholar
Gillis, C. N., Greene, N. M., Cronau, L. H., and Hammond, G. L., 1972, Circulation Res. 30: 666.
PubMed CAS Google Scholar
Gillis, C. N., and Iwasawa, Y., 1972, Federation Proc. 31: 599 Abs.
Google Scholar
Ginn, R. W., and Vane, J. R., 1968, Nature (London) 219: 740.
Article CAS Google Scholar
Gobel, A. J., Hay, D. R., and Sandler, M., 1955, Lancet 2: 1016.
Article Google Scholar
Goffinet, J. A., and Mulrow, P. J., 1965, Clin. Res. 11: 408.
Google Scholar
Gruby, L. A., Rowlands, C., Varley, B. Q., and Wyllie, J. H., 1971, Brit. J. Surg. 58: 525.
Article PubMed CAS Google Scholar
Hébert, F., Fouron, J. C., Boileau, J. C., and Biron, P., 1972, Am. J. Physiol. 223: 20.
PubMed Google Scholar
Heinemann, H. O., and Fishman, A. P., 1969, Physiol. Rev. 49: 1.
Google Scholar
Hinman, J. W., 1972, Ann. Rev. Biochem. 41: 161.
Article PubMed CAS Google Scholar
Hodge, R. L., Ng, K. K. F., and Vane, J. R., 1967, Nature (London) 215: 138.
Article CAS Google Scholar
Horton, E. W., Main, I. H. M., and Thompson, C. J., 1965, J. Physiol London 180: 514.
PubMed CAS Google Scholar
Hughes, J. R., Gillis, C. N., and Bloom. F. E., 1969, J. Pharmacol. Exp. Therap. 169: 237.
CAS Google Scholar
Junod, A. F., 1971, Federation Proc. 30: 671 Abs.
Google Scholar
Karim, S. M. M., 1972, The Prostaglandins, MTP, Oxford.
Google Scholar
Kaufman, R. M., Airo, R., Pollock, S., and Crosby, W. H., 1965, Blood 26: 720.
PubMed CAS Google Scholar
Leary, W. P. P., and Ledingham, J. G., 1969, Nature (London) 222: 959.
Article CAS Google Scholar
Lilja, B., and Lindell, S. E., 1961, Brit. J. Pharmacol. 16: 203.
PubMed CAS Google Scholar
McCarthy, D. A., Potter, D. E., and Nicolaides, E. D., 1965, J. Pharmacol. Exp. Therap. 148: 117.
CAS Google Scholar
McGiff, J. C., Terragno, N. A., Strand, J. C., Lee, J. B., Lonigro, A. J., and Ng, K. K. F., 1969, Nature (London) 223: 742.
Article CAS Google Scholar
Moore, T. C., Normell, L., and Eiseman, B., 1963, Arch. Surg. (Chicago) 87: 103.
Article Google Scholar
Ng, K. K. F., and Vane, J. R., 1967, Nature (London) 216: 762.
Article CAS Google Scholar
Ng, K. K. F., and Vane, J. R., 1968, Nature (London) 218: 144.
Article CAS Google Scholar
Piper, P. J., and Vane, J. R., 1969, Nature (London) 223: 29.
Article CAS Google Scholar
Piper, P. J., and Vane, J. R., 1971, Ann. N. Y. Acad. Sci. 180: 363.
Article PubMed CAS Google Scholar
Piper, P. J., Vane, J. R., and Wyllie, J. H., 1970, Nature (London) 225: 600.
Article CAS Google Scholar
Pojda, S., and Vane, J. R., 1971, Brit. J. Pharmacol. 42: 558.
CAS Google Scholar
Rapport, M. M., Greene, A. A., and Page, I. H., 1948a, Science 108: 329.
Article PubMed CAS Google Scholar
Rapport, M. M., Greene, A. A., and Page, I. H., 1948b, J. Biol. Chem. 176: 1243.
PubMed CAS Google Scholar
Richardson, J. B., and Beaulnes, A., 1971, J. Cell. Biol. 51: 419.
Article PubMed CAS Google Scholar
Ryan, J. W., Roblero, J., and Stewart, J. M., 1968, Biochem. J. 110: 795.
PubMed CAS Google Scholar
Ryan, J. W., Roblero, J., and Stewart, J. M., 1969, Pharm. Res. Comm. 1: 192.
Article Google Scholar
Said, S. I., 1968, New Engl. J. Med. 279: 3.
Google Scholar
Sandler, M., 1972, Lancet 1: 618.
Article PubMed CAS Google Scholar
Scholz, H. W., and Biron, P., 1969, Rev. Can. Biol. 28: 197.
PubMed CAS Google Scholar
Spector, W. S., 1956, Handbook of Biological Data, p. 285, Saunders, Philadelphia.
Google Scholar
Stacey, R. S., 1961, Brit. J. Pharmacol. 16: 284.
PubMed CAS Google Scholar
Starling, E. H., and Verney, E. D., 1925, Proc. Roy. Soc. B 97: 321.
Article CAS Google Scholar
Steggeda, F. R., Essex, H. E., and Mann, F. C., 1935, Am. J. Physiol. 112: 70.
Google Scholar
Stewart, J. M., 1968, Federation Proc. 27: 534.
Google Scholar
Thomas, D. P., and Vane, J. R., 1967, Nature 216: 335.
Article PubMed CAS Google Scholar
Todrick, A., and Tait, C., 1969, J. Pharm. Pharmacol. 21: 751.
Article PubMed CAS Google Scholar
Tranza, J. P., DaPrada, M., and Pletscher, A., 1966, Nature (London) 212: 1574.
Article Google Scholar
Vane, J. R., 1964, Brit. J. Pharmacol. 23: 360.
PubMed CAS Google Scholar
Vane, J. R., 1968, in: Importance of Fundamental Principles in Drug Evaluation (Tedeschi, D. H., and Tedeschi, R. E., eds.), p. 217, Raven Press, New York.
Google Scholar
Vane, J. R., 1969, Brit. J. Pharmacol. 35: 209.
CAS Google Scholar
Vane, J. R., 1974, in: Angiotensin (Bumpus, M., and Page, I. H., eds.), Springer-Verlag, New York.
Google Scholar
Vane, J. R., and Williams K. I., 1970, Brit J. Pharmacol. 38: 444P.
Google Scholar
Weeks, J. R., 1972, Ann. Rev: Pharmacol. 12: 317.
Article CAS Google Scholar
Yang, H. Y. T., Erdös, E. G., and Levin, Y., 1971, J. Pharmacol. Exp. Therap. 177: 291.
CAS Google Scholar

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John R. Vane
Present address: Wellcome Research Laboratories, Langley Court, Beckenham, Kent, England

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Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons, London, England
John R. Vane

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Institute of Physiology and Medical Biophysics, University of Uppsala, Uppsala, Sweden
Torsten Teorell
Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA
Torsten Teorell
Biomedical Engineering and Instrumentation Branch Division of Research Services, National Institutes of Health, Bethesda, Maryland, USA
Robert L. Dedrick
Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism, and Digestive Diseases National Institutes of Health, Bethesda, Maryland, USA
Peter G. Condliffe

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Vane, J.R. (1972). The Role of the Lungs in the Metabolism of Vasoactive Substances. In: Teorell, T., Dedrick, R.L., Condliffe, P.G. (eds) Pharmacology and Pharmacokinetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2055-5_11

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DOI: https://doi.org/10.1007/978-1-4684-2055-5_11
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