Abstract
Nicotine is one of the most interesting drugs used by man. Millions of humans (approximately 60 million in the USA) use and have used this drug via tobacco, but its mechanism of reinforcement has yet to be elucidated. Although nicotine, unlike morphine and cocaine, does not reinforce behavior in sub-human species, it does appear to be quite reinforcing in man. Behavioral effects associated with the use of nicotine have not been clearly documented in humans. In animals, however, the drug produces a variety of effects dependent upon baseline behaviors prior to drug administration. Thus, if baseline behaviors are low, nicotine increases these rates whereas a decrease is observed if the baseline behavior rate is initially high. None of these actions of nicotine have been reported in humans, however, and there is still little evidence indicating how the drug is affecting human behavior.
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Rosecrans, J.A., Chance, W.T. (1977). Cholinergic and Non-Cholinergic Aspects of the Discriminative Stimulus Properties of Nicotine. In: Lal, H. (eds) Discriminative Stimulus Properties of Drugs. Advances in Behavioral Biology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3090-5_10
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DOI: https://doi.org/10.1007/978-1-4684-3090-5_10
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