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Acetylcholine and Cyclic GMP

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Cholinergic Mechanisms and Psychopharmacology

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 24))

Abstract

This article examines some of the evidence for or against the hypothesis that guanosine 3′,5′-cyelic monophosphate (cGMP) is the intracellular mediator of the actions of acetylcholine (ACh), with particular emphasis on the situation in the mammalian nervous system. This idea arose following the widespread acceptance of a parallel role of adenosine 3′, 5′-cyclic monophosphate (cAMP) as the intracellular mediator of catecholaminergic (especially ß-receptor) activation (32). It was first put forward by George et al. (8) when they observed a correlation between the depressant effects of ACh on the rat heart and its cGMP content; and it was enthusiastically adopted and promoted by Greengard and his collaborators (11, 12, 20). The possibility that, in a variety of tissues, cAMP and cGMP systematically act in opposite fashion, thus providing the mechanism for “bidirectional” control of intracellular processes, has been much discussed (9, 10).

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Author information

Authors and Affiliations

  1. Department of Anaesthesia Research, McGill University, Montreal, Canada

    K. Krnjevic

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  1. K. Krnjevic
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Editor information

Editors and Affiliations

  1. University of California School of Medicine, Los Angeles, California, USA

    Donald J. Jenden

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© 1978 Plenum Press, New York

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Krnjevic, K. (1978). Acetylcholine and Cyclic GMP. In: Jenden, D.J. (eds) Cholinergic Mechanisms and Psychopharmacology. Advances in Behavioral Biology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3096-7_19

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  • DOI: https://doi.org/10.1007/978-1-4684-3096-7_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3098-1

  • Online ISBN: 978-1-4684-3096-7

  • eBook Packages: Springer Book Archive

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