Summary
Two groups of antibiotics, the polymyxins and the polyenes, owe their antimicrobial activity to their ability to bind to and disrupt microbial cell membranes. The polymyxins bind to acid phospholipids in gram-negative bacteria, whereas, the polyenes attach to sterols in membranes of fungi and mycoplasma. These drugs also bind to cell membranes of vertebrates and may not only owe their toxicity to this effect, but also may be largely inactivated at membrane-binding sites.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bryant, R.E., and Hammond, D. Interaction of purulent material with antibiotics used to treat Pseudomonas infections. Antimicrob. Agents Chemother. 6:702–707, 1974.
Butler, W.T., and Cotlove, E. Increased permeability of human erythrocytes induced by amphotericin B. J. Infect. Dis. 123: No. 4, 341–350, 1971.
Craig, W.A., and Kunin, C.M. Dynamics of binding and release of the polymyxin antibiotics by tissues. J. Pharm. Exp. Ther. 184: 757–766, 1973.
DuBuy, H.G., and Showacre. Selective localization of tetracycline in mitochondria of living cells. Science 133:196–197, 1961.
Kornguth, M.L., and Kunin, C.M. Binding of antibiotics to human intracellular erythrocyte proteins: hemoglobin and carbonic anhydrase. In press.
Kunin, C.M. Binding of antibiotics to tissue homogenates. J. Infect. Dis. 121:55–64, 1970.
Kunin, C.M., and Bugg, A. Binding of polymyxin antibiotics to tissues: The major determinant of distribution and persistence in the body. J. Inf. Eis. 124:394–400, 1971.
Kunin, CM., and Bugg, A. Eecovery of tissue bound polymyxin B and colistimethate. Proc. Soc. Exp. Biol. Med. 137:786–790, 1971.
Lampen, J.O., Arnow, P.M., Borowska, Z., and Laskin, A.I. Location and role of sterol at nystatin-binding sites. J. Bact. 84:1152–1160, 1962.
Newton, B.A. The properties and mode of action of the polymyxins. Bact. Fev. 20:14–27, 1956.
Keiblein, W.J., Watkins, P.D., and Wagman, G.H. Binding of Gentamicin and other animoglycoside antibiotics to mycelium of various actinomycetes. Antimicrob. Agents Chemother. 4:602–606, 1973.
Wagman, G.H., Bailey, J.V., and Weinstein, M.J. Binding of aminoglycosides to feces. Antimicrob. Agents Chemother. 6:415–417, 1974.
Weissmann, G., Pras, M., and Hirschorn, R. A common mechanism for fungicidal and nephrotoxic effects of amphotericin B. J. Clin. Invest. 45:1084, 1966.
Zimelis, V.M., and Jackson, G.G. Activity of aminoglycoside antibiotics against Pseudomonas aeruginosa: Specificity and site of calcium and magnesium antagonism. J. Infect. Dis. 127:663–669, 1973.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Kunin, C.M. (1976). Tissue Binding of Antibiotics. In: Williams, J.D., Geddes, A.M. (eds) Pharmacology of Antibiotics. Chemotherapy, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3123-0_1
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3123-0_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3125-4
Online ISBN: 978-1-4684-3123-0
eBook Packages: Springer Book Archive