Skip to main content
SpringerLink
Log in

Reticulocytosis and Bone Marrow cAMP Level in Rats Following Physical Exercises

  • Chapter
Oxygen Transport to Tissue VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 191))

Abstract

In the course of intensive physical exercises the blood serum erythropoietin level becomes elevated 16,21. Erythropoietin, being a protein hormone of a big molecular weight, does not penetrate the target cell, but is bound by a surface receptor 15 and affects the processes occurring within the erythropoietin-sensitive cell according to the generally accepted theory of the “second messenger”. As it has been demonstrated2,5,7 erythropoietin triggers an increase of cAMP in the bone marrow cells. On the other hand, an elevation in the intracellular cAMP concentration has been shown to stimulate erythropoiesis in vitro.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. H. Gegemann and H.G. Harwerth, “Praktische Hämatologie”, George Thieme Verlag, Stuttgart (1974).

    Google Scholar 

  2. J.E. Brown and J.W. Adamson, Studies of the influence of cyclic nucleotides on in vitro haemoglobin synthesis, Brit. J. Haematol., 35:193 (1977).

    Article  CAS  Google Scholar 

  3. Z. Brzezinska, W. Kowalski and K. Nazar, Activity of the adrenergic system during prolonged running in dogs, Acta Physiol.Pol., 24:339 (1973).

    PubMed  CAS  Google Scholar 

  4. J.W. Byron, Evidence for a β -adrenergic receptor initiating DNA synthesis in haemopoietic stem cells, Exptl.Cell.Res., 71:228 (1972).

    Article  PubMed  CAS  Google Scholar 

  5. F. Chiuini, G. Della Tore, G. Fano and A. Viti, Early increase of cyclic adenosine monophosphate level induced by erythropoietin on rabbit bone marrow cell suspensions, Acta Haematol., 61:251 (1979).

    Article  PubMed  CAS  Google Scholar 

  6. Z. Dabrowski, Z. Szygula and H. Miszta, Do changes in bone marrow pressure contribute to the egress of cells from bone marrow?, Acta Physiol.Pol., 32:729 (1981).

    PubMed  CAS  Google Scholar 

  7. G. Della Tore, G. Fano and G. Menchetti, cAMP-cGMP ratio and Hb concentration in rabbit bone marrow cells stimulated by erythroproietin and NaF, IRCS Medical Sci., 9:344 (1981).

    Google Scholar 

  8. T. Ganchev, The influence of isoprenaline beta-adrenergic stimulation on erythropoiesis in white rats, Agressologie, 16:301 (1975).

    PubMed  CAS  Google Scholar 

  9. A.G. Gilman, A protein binding assay for adenosine 3′: 5′-cyclic monophosphate, Proc.Natl.Acad.Sci.U.S., 67:305 (1970).

    Article  CAS  Google Scholar 

  10. D. Gorshein, E.H. Reisner Jr. and F.H. Graber, Tissue culture of bone marrow. V. Effect of 5 β /H/ steroids and cyclic AMP on heme synthesis, Am.J.Physiol., 228:1024 (1975).

    PubMed  CAS  Google Scholar 

  11. P.M. Gross, D.D. Heistad and M.L. Marcus, Neurohumoral regulation of blood flow to bones and marrow, Am.J.Physiol., 237:H440 (1979).

    PubMed  CAS  Google Scholar 

  12. W. Kindermann, A. Schnabel, W.M. Schmitt, G. Biro, J. Cassens and F. Weber, Catecholamines, growth hormone, Cortisol, insulin and sex hormones in anaerobic and aerobic exercise, Eur.J.Appl. Physiol., 49:289 (1982).

    Article  Google Scholar 

  13. V. Koivisto, R. Hendler, E. Nadel and Ph. Felig, Influence of physical training on the fuel — hormone response to prolonged low intensity exercise, Metabolism, 31:192 (1982).

    Article  PubMed  CAS  Google Scholar 

  14. J. Kolena and C.P. Channing, Stimulatory effects of LH, FSH, and Prostaglandins upon cyclic 3′, 5′ — AMP levels in porcine gran-dulosa cells, Endocrinology, 90:1543 (1972).

    Article  PubMed  CAS  Google Scholar 

  15. M.D. Lafferty, G.A. Ackerman, Ch.D.R. Dunn and R.D. Lange, Ultrastructural, immunocytochemical localisation of presumptive erythtropoietin binding sites on developing erythrocytic cells of normal human bone marrow, J.Histochem.Cytochem., 29:49 (1981).

    Article  PubMed  CAS  Google Scholar 

  16. R. Lindemann, R. Ekanger, P.K. Opstad, M. Nummestad and R. Ljosland, Hematological changes in normal men during prolonged severe exercise, Amer.Corr.Ther.J., 37:107 (1978).

    Google Scholar 

  17. M. Pawlikowski and J. Lewandowski, Cyclic adenosine 3′, 5′ -- monophosphate as the intracellular mediator of hormonal action, Endokrynol. Polska, 24:105 (1973).

    CAS  Google Scholar 

  18. Z. Szygula, K. Spodaryk, Z. Dabrowski and H. Miszta, Post-effort anaemia and hemolytic phenomena during physical exercises, (in press).

    Google Scholar 

  19. K.C. Tovey, K.G. Oldham and J.A.M. Whelan, A simple direst assay for cyclic AMP in plasma and other biological samples using an improved competitive protein binding technique, Clinica Chemica Acta, 56:221 (1974).

    Article  CAS  Google Scholar 

  20. J.E. Wilkerson, S.M. Horvath and B. Gutin, Plasma testosterone during treadmill exercise, J.Appl.Physiol.:Resp., Environ. Exercise Physiol., 49:249 (1980).

    CAS  Google Scholar 

  21. J. Zivny, J. Neuwirt and T. Travnicek, The effect of lactic acid on erythropoietin production and the rate of disappearance of erythropoietin from rat plasma during exercise, Life Sciences, 10:11 (1971).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Sport Medicine, Akademy of Physical Education, Al. Planu 6-letniego 62a, 31-571, Krakow, Poland

    Z. Szygula

  2. Laboratory of Animal Physiology and Toxicology, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, ul. Karasia 6, 30-060, Krakow, Poland

    Z. Dabrowski & H. Miszta

  3. Department of Physiology and Biochemistry, Academy of Physical Education, Al, Planu 6-letniego 62a, 31-571, Krakow, Poland

    R. Kubica

Authors
  1. Z. Szygula
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Z. Dabrowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Kubica
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Miszta
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Nijmegen, Nijmegen, The Netherlands

    F. Kreuzer  & Z. Turek  & 

  2. University of Alabama at Birmingham, Birmingham, Alabama, USA

    S. M. Cain

  3. Northwestern University, Evanston, Illinois, USA

    T. K. Goldstick

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Szygula, Z., Dabrowski, Z., Kubica, R., Miszta, H. (1985). Reticulocytosis and Bone Marrow cAMP Level in Rats Following Physical Exercises. In: Kreuzer, F., Cain, S.M., Turek, Z., Goldstick, T.K. (eds) Oxygen Transport to Tissue VII. Advances in Experimental Medicine and Biology, vol 191. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3291-6_57

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3291-6_57

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3293-0

  • Online ISBN: 978-1-4684-3291-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation