Abstract
Stimulation of the immune system by foreign materials usually results in the production of antibody. The basis for regulation of the duration, intensity, and amount of antibody is not well understood. The first theories that made sense were based on the demonstration that the Darwinian rules that had been put to elegant experimental tests by Luria and Delbruck also applied to the immune system. These ideas were fairly straightforward, in keeping with what was known about the immune system at that time: antibody responses were thought of as a result of the relative concentrations of antigen and specific antibodies in serum; complexing of antibodies with antigen were thought to mask antigenic determinants and gradually decrease the effective concentration of antigenic stimulation (see Uhr and Moller, 1968). Additional experimental analysis suggested that antigen-antibody complexes might themselves inactivate antibody-secreting lymphocytes (or their immediate precursors) either by altering the molecular configuration of antigen (Diener and Feldmann, 1972) or via a direct effect of the Fc portion of antibodies (Chan and Sinclair, 1971; Murgitta and Vas, 1972). In either case, these models relied upon three basic elements: antibody, antigen, and the antibody-secreting cell.
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Woodland, R.T., Cantor, H. (1980). VH Gene Products Allow Specific Communication among Immunologic Cell Sets. In: Warner, N.L. (eds) Contemporary Topics in Immunobiology. Contemporary Topics in Immunobiology, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3701-0_7
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