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Investigating Nucleic Acids, Nucleoproteins, Polynucleotides, and their Interactions with Small Ligands by Electro-Optical Methods

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Molecular Electro-Optics

Part of the book series: NATO Advanced Study Institutes Series ((NSSB,volume 64))

Abstract

Nucleic acids and nucleoproteins molecules are particularly suitable for investigation through electro-optical methods: (i) they form relatively rigid polyelectrolytic particles which are sufficiently asymmetric and electrically polarizable to be significantly oriented in an electric field; (ii) they hold planar heterocyclic chromophores (the purine and pyrimidine bases) absorbing in an easily accessible wavelength region (the 260 nm band); (iii) many ligands of biological interest interacting with these molecules are also planar heterocyclic dye rings, absorbing in the visible or near ultraviolet range. These considerations are also applicable to some extent to polynucleotides although some of them usually form less rigid structures.

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Authors and Affiliations

  1. Laboratoire de Chimie Physique, Université de Liège (B6), Sart-Tilman, B-4000, Liege, Belgium

    Claude Houssier

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  1. Claude Houssier
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  1. Rensselaer Polytechnic Institute, Troy, New York, USA

    Sonja Krause (Director of the Institute) (Director of the Institute)

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Houssier, C. (1981). Investigating Nucleic Acids, Nucleoproteins, Polynucleotides, and their Interactions with Small Ligands by Electro-Optical Methods. In: Krause, S. (eds) Molecular Electro-Optics. NATO Advanced Study Institutes Series, vol 64. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3914-4_17

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  • DOI: https://doi.org/10.1007/978-1-4684-3914-4_17

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