Abstract
Saccharomyces cerewisiae is a lower eukaryote ideal for many current biological studies. It shares certain properties with higher eukaryotes: a nucleus containing multiple chromosomes packed in chromatin structures, and specialized organelles such as vacuoles and mitochondria. In addition, the organization of yeast structural genes is similar to that of higher eukaryotic cells: most functionally related genes are scattered on different chromosomes rather than linked together in operons (21). Yet, while yeast are more complex than bacteria, they still share many of the technical advantages which permitted rapid progress in the genetic and biochemical studies of prokaryotic organisms. Some of the properties which make yeast particularly amenable to study are their short generation time, the existence of both stable haploids and diploids, and the ease of replica plating and mutant isolation. Furthermore, the sophisticated classical genetics of yeast allows one to fully exploit recent technological advances in genetic engineering.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abelson, J. 1980. Science 209, 1319–1321.
Bach, M.L. and F. Lacroute. 1972. Mol. Gen. Genet. 115, 126–130.
Beggs, J.D. 1978. Nature 275, 104–109.
Borst, P. and L.A. Grivell. 1978. Cell 15, 705–723.
Bostian, K.A., J.E. Hopper, D.T. Roger, and D.J. Tipper. 1980. Cell 19, 403–414.
Botstein, D., S.C. Falco, S.E. Stewart, M. Brennan, S. Scherer, D.J. Stinchcomb, K. Struhl, and R. Davis. 1979. Gene 8, 17–24.
Broach, J.R., J.F. Atkins, C. McGill, and L. Chow. 1979. Cell 16, 827–839.
Broach, J.R., J.N. Strathern, and J.B. Hicks. 1979. Gene 8, 121–133.
Bussey, H. 1972. Nature New Biol. 235, 73–75.
Bussey, H. and D. Sherman. 1973. Biochim. Biophys. Acta 298, 868–875.
Cameron, J.R., P. Philippsen, and R. W. Davis. 1977. Nucleic Acids Res. 4, 1429–1448.
Chatoo, B., F. Sherman, D. Azubalis, T. Fjellstedt, D. Mehnert, and M. Ogur. 1979. Genetics 93:51–65.
Church, G., P. Slonimski, W. Gilbert, 1979. Cell 18, 1209–1215.
Clarke, L. and J. Carbon. 1976. Cell 9, 91–99.
Clarke-Walker, G.D. and G. L. Miklos. 1974. Eur. J. Biochem. 41, 263–267.
Douglas, H. and D. Hawthorne. 1964. Genetics 49, 837–844.
Fink, G.R. 1966. Genetics 53, 445–459.
Fisher, C. 1969. Biochem. Biophys. Res. Commun. 34, 306–310.
Fowell, R.R. 1969. In “The Yeasts”, Vol. 1 (A.H. Rose and J. S. Harrison, eds.), Academic Press, N.Y., 303–383.
Gerbaud, C., P. Fournier, H. Blanc, M. Aigle, H. Heslot, and M. Guerineau. 1979. Gene.5, 233–253.
Greer, H. and G.R. Fink. 1975. In “Methods in Cell Biology, Vol. XI, Yeast Cells.” (D. Prescott, ed.) Academic Press, N.Y. 247–272.
Grunstein, M. and D.S. Hogness. 1975. Proc. Natl. Acad. Sci. USA 72, 3961–3965.
Guerineau, M., C. Grandchamp, P.P. Slonimski. 1976. Proc. Natl. Acad. Sci. USA 73, 3030–3034.
Hartwell, L.H. 1974. Bacteriol. Rev. 38, 164–198.
Hawthorne, D.C. and R.K. Mortimer. 1960. Genetics 45, 1085–1110.
Henry, S., T. Donahue, and M. Culbertson. 1975. Molec. Gen. Genet. 143, 5–11.
Herring, A.J. and E.A. Bevan. 1974. J. Gen. Virol. 22, 387–394.
Hicks, J., J. Strathern, and I. Herskowitz. 1977. In “DNA Insertion Elements, Plasmids and Episomes” (A. Bukhari, J. Shapiro, and S. Adhya, eds.). Cold Spring Harbor Laboratory, N.Y., 457–462.
Hicks, J.B., A. Hinnen, and G.R. Fink. 1978. Cold Spring Harbor Symp. Quant. Biol. 43, 1305–1313.
Hicks, J., J. Strathern, and A.J. Klar. 1979. Nature 282, 478–483.
Hilger, F. and R.K. Mortimer. 1980. J. Bact. 141, 270–274.
Hinnen, A., J. Hicks, and G.R. Fink. 1978. Proc. Natl. Acad. Sci. USA 75, 1929–1933.
Hinnen, A., P. Farabaugh, C. Ilgen, and G.R. Fink. 1979. ICN-UCLA Symp. 14, 43–50.
Hitzeman, R.A., A.C. Chinault, A.J. Kingsman, and J. Carbon. 1979. INC-UCLA Symp. 14, 57–68.
Hollenberg, C.P., P. Borst, E.F. Van Bruggen. 1970. Biochim. Biophys. Acta 209, 1–15.
Hollenberg, C.P., A. Degelmann, B. Kustermann-Kuhn, and H.D. Royer. 1976. Proc. Natl. Acad. Sci. USA 72, 2072–2076.
Hsiao, C.H. and J. Carbon. 1979. Proc. Natl. Acad. Sci. USA 76, 3829–3833.
Johnston, J.R. and R.K. Mortimer. 1959. J. Bact. 78. 292.
Korch, C., F. Lacroute, and F. Exinger. 1974. Mol. Gen. Genet. 133, 63–75.
Lauer, G., T.M. Roberts, and L.C. Klotz. 1977. J. Mol. Biol. 114, 507–526.
Lazowka, J., C. Jacq, P. Slonimski. 1980. Cell 22, 333–348.
Linnane, A.W., J.M. Haslam, H.B. Lukins, and P. Nagley. 1972. Ann. Rev. Microbiol. 25, 163–198.
Livingston, D.M. 1977. Genetics 86, 73–84.
Mortimer, R.K. and D.C. Hawthorne. 1969. In “The Yeasts”, Vol. I, (A.H. Rose and J.S. Harrison, eds.). Academic Press, N.Y. 385–460.
Mortimer, R.K. and T.R. Manney. 1971. In “Chemical Mutagens” Vol. I. (A. Hollaender, ed.), Plenum Press, N.Y., p. 289–310.
Mortimer, R.K. and D.C. Hawthorne 1973. Genetics 74., 33–54.
Mortimer, R.K. and D.C. Hawthorne 1975. In “Methods in Cell Biology”, Vol. XI (D.M. Prescott, ed.). Academic Press, N.Y. 221–233.
Nagley, P. and A.W. Linnane. 1972. J. Mol. Biol. 66, 181–193.
Nasmyth, K.A. and K. Tatchell. 1980. Cell 19, 753–764.
Perkins, D.D. 1949. Genetics 34, 607–626.
Petes, T. 1980. Ann. Rev. Biochem. 49, 845–876.
Petes, T. and D.H. Williamson. 1975. Cell 4, 249–253.
Ratzkin, B. and J. Carbon. 1977. Proc. Natl. Acad. Sci. USA 24, 487–491.
Seherer, S. and R.W. Davis. 1979. Proc. Natl. Acad. Sci. USA 76, 4951–4955.
Sherman, F. 1975. In “Methods in Cell Biology, Vol. XI. Yeast Cells.” (D. Prescott, ed.). Academic Press, N.Y., 189–199.
Sherman, F. and H. Roman. 1963. Genetics 48, 255–261
Sherman, F. and C. W. Lawrence. 1974. In “Handbook of Genetics” Vol. 1. (R.C. King, ed.). Plenum Publishing Corporation, N.Y. 359–393.
Sherman, F., J. Stewart, M. Jackson, R. Gilmore, and J. Parker. 1974. Genetics 77, 255–284.
Silver, J. and N. Eaton. 1969. Biochem. Biophys. Res. Commun. 34, 301–305.
Sinclair, J.H., B.J. Stevens, P. Sanghavi, and M. Rabinowitz. 1967. Science 156, 1234–1237.
Snow, R. 1966. Nature 211, 206–207.
Somers, J.M. and E.A. Bavan. 1969. Genet. Res. 13, 71–83.
Stinchcomb, D.T., K. Struhl, and R.W. Davis. 1979. Nature 282, 39–43.
Storms, R.K., J.B. McNeil, P. S. Khandlkar, G. An, J. Parker, and J. D. Friesen. 1979. J. Bacteriol. 140, 73–82.
Struhl, K., D.T. Stinchcomb, S. Scherer, and R.W. Davis. 1979. Proc. Natl. Acad. Sci. USA 76, 1035–1039.
Szostak, J. and R. Wu. 1979. Plasmid 2, 536–554.
Takano, I. and Y. Oshima. 1970. Genetics 65, 421–427.
Thouvenot, D.R. and C.M. Bourgeois. 1971. Ann. Inst. Pasteur 120, 617–625.
Walton, E.F., B.L. Carter, and J.R. Pringle. 1979. Molec. Gen. Genet. 171, 111–114.
Wickner, R. 1978. Genetics 88, 419–425.
Wickner, R. 1979. Genetics 92, 803–821.
Williamson, D.H. 1970. Symp. Soc. Exp. Biol. 24, 247–276.
Williamson, V.M., J. Bennetzen, E.T. Young, K. Nasmyth, and B.D. Hall. 1979. Nature 283, 214–216.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Greer, H. (1981). Mechanisms of Yeast Genetics. In: Hollaender, A., Rabson, R., Rogers, P., Pietro, A.S., Valentine, R., Wolfe, R. (eds) Trends in the Biology of Fermentations for Fuels and Chemicals. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3980-9_14
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3980-9_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3982-3
Online ISBN: 978-1-4684-3980-9
eBook Packages: Springer Book Archive