Abstract
I note that the title of this Conference indicates GENETIC ENGINEERING OF MICROORGANISMS in large print and in small print, “for chemicals”. In this paper, you will have to be satisfied with the “for Chemicals” part of that title because we have not yet arrived at the genetic engineering phase. We soon hope to enter into genetic engineering especially with respect to the production of one of our halogenating enzymes and I will refer briefly to that at the end of this manuscript. I am sure you have seen the television commercials where Mother Nature, accompanied by flashes of lightning and loud noises says “Mother Nature likes this” or “Mother Nature doesn’t like that”. It was with that thought in mind that I arrived at a title for this paper. Most laymen and many scientists think only of industrial pollution and harmful chemicals when discussing roles for halogenated organic molecules in nature. However, I hope to persuade you that Mother Nature does like some halogenated compounds and indeed, has reserved halogenated compounds for some very special functions and purposes.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Takeda, R. (1958) Structure of a new antibiotic, pyoluteorin. J. Amer. Chem. Soc., 80: 4749.
Birch, A.J., P. Hodge, R. W. Rickards, R. Takeda, and F. R. Watson (1964) The structure of pyoluteorin. J. Chem. Soc., 1964: 2641.
The Merck Index (1968) 8th Edition. Merck and Co., Inc., Rahway, N.J., p. 251.
Herzog, H.L., E. Meseck, S. DeLorenzo, A. Murawski, W. Charney, and J.P. Rosselet (1965) Chemistry of antibiotics from Mlcromonospora III. Isolation and characterization of everninomicin D and everninomicin B. Appl. Microbial., 13: 515.
Clutterbuck, P.W., S.L. Mukhopadhyay, A.E. Oxford, H. Raistrick (1940) A survey of chlorine metabolism by moudis (B) Caldariomycin, C5H8O2Cl2, a metabolic product of Caldariomyces fumago Woronichin. Biochemistry, 34: 664.
Oxford, A.E., H. Raistrick, and P. Simonart (1939) XXIXX. Studies in the biochemistry of microorganisms. LX. Griseofulvin, C17H17O6Cl, a metabolic product of Penicillium griseofulvin. Dierx. Biochem. J., 33: 240.
Raistrick, H. and G. Smith (1936) Studies in the biochemistry of microorganisms. Ll. The metabolic products of Aspergillus terreus Thom. II. Two new chlorine-containing mould metabolic products, geodin and erdin. Biochem. J., 30: 1315.
Barton, D.H.R. and A.I. Scott (1958) The constitutions of geodin and erdin. J. Chem. Soc., 1958: 1767.
Personal communication.
Elovson, J. and P.R. Vagelos (1969) A new class of lipids: Chlorosulfolipids. Proc. Natl. Acad. of Sci., 62: 957.
Elovson, J. and P.R. Vagelos (1970) Structure of the major species of chlorosulfolipid from Ochromonas danica. 2,2,11,13, 15,16-Hexachloro-n-docosane 1,14-disulfate. Biochem., 9: 3110.
Haines, T.H., M. Pousada, B. Stern, and G.L. Mayers (1969) Microbial sulpholipids: (R)-13-Chloro-l-(R)-14-docosanediol disulphate and polychlorosulpholipids in Ochromonas danica. Biochem. J., 113: 565.
Mayers, G.L., M. Pousada, and T.H. Haines (1969) Microbial sulfolipids. III. The disulphate of (+)01,14-docosanediol in Ochromonas danica. Biochemistry, 8: 2981.
Marais, J.S.C. (1944) Monofluoroacetic acid, the toxic principle of “gifblaar in Dichapetalum cymosum” (Hook) Engl. Onderstepoort J. Vet. Sci., 20: 67.
Peters, R.A. and R.J. Hall (1959) Further observations on the toxic principle of Dichapetalum toxicarium. Biochem. Pharmacol., 2: 25.
Peters, R.A., R.J. Hall, P.F.V. Ward, and N. Sheppard (1960) The chemical nature of the toxic compounds containing fluorine in the seeds of Dichapetalum toxicarium. Biochem. J., 77: 17.
Ward, P.F.V., R.J. Hall, and R.A. Peters (1964) Fluoro-fatty acids in the seeds of Dichapetalum toxicarium. Nature, 201: 611.
Irie,T.,M. Suzuki, E. Kurosawa, and T. Masamune (1966) Laurinterol and debromolaurinterol, constituents from Laurencia intermedia. Tetrahedron Lett., 1966: 1837.
Beissner, R.S., W.J. Guilford, R.M. Coates, and L.P. Hager(1981) Synthesis of brominated heptanones and bromoform by a bromoperoxidase of marine origin. Biochem., in press.
Shaw, P.D., J.R. Beckwith, and L.P. Hager (1959) Biological chlorination. II. The biosynthesis of a-chloroevulinic acid J. Biol. Chem., 234: 2560.
Morris, D.R. and L.P. Hager (1966) Chloroperoxidase. I. Isolation and properties of the crystalline glycoprotein. J. Biol. Chem., 241: 1763.
Moore, R.E., B.J. Burreson, and P. Roller (1975) Tetrahedron Lett., 1975: 473.
Theiler, R., J. Siuda, and L.P. Hager (1978b) Bromoperoxidase from the red algae Bonnemaisonia hamifera. In: Drugs and Food from the Sea - Myth or Reality? ( P.N. Kaul, Ed.) p. 153, Univ. of Okla. Press, Norman, Oklahoma.
Theiler, R., J. Cook, and L.P. Hager (1978a) Halohydrocarbon synthesis by bromoperoxidase. Science, 202: 1094
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Hager, L.P. (1982). Mother Nature Likes Some Halogenated Compounds. In: Hollaender, A., DeMoss, R.D., Kaplan, S., Konisky, J., Savage, D., Wolfe, R.S. (eds) Genetic Engineering of Microorganisms for Chemicals. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4142-0_31
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4142-0_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4144-4
Online ISBN: 978-1-4684-4142-0
eBook Packages: Springer Book Archive