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Stimulated Phosphatidylinositol Turnover A Brief Appraisal

  • Chapter
Contemporary Metabolism

Abstract

The phospholipid phosphatidylinositol (Fig. 1) (PI) is ubiquitous in animal tissues and occurs as a minor component (10 ± 5%; White, 1973) of the lipid bilayer of their cellular membranes. Its chemical structure is illustrated in Fig. 1, and the ester bonds that the various phospholipases can cleave are indicated. It is our intention in this introduction to review only briefly the history of the study of PI turnover and its relationship to cell stimulation, as detailed accounts can be found in reviews by L. E. Hokin (1968), Hawthorne and White (1975), and Michell (1975).

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Authors and Affiliations

  1. Department of Biochemistry, Agricultural Research Council Institute of Animal Physiology, CB2 4AT, Babraham, Cambridge, England

    R. F. Irvine & R. M. C. Dawson

  2. Center for Endocrinology, Metabolism, and Nutrition and Departments of Medicine and Biochemistry, Northwestern University Medical School, Chicago, Illinois, 60611, USA

    N. Freinkel

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  1. R. F. Irvine
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  1. Northwestern University Medical School, Chicago, Illinois, USA

    Norbert Freinkel M. D. (Director, Center for Endocrinology, Metabolism, and Nutrition, Kettering Professor of Medicine, Professor of Biochemistry) (Director, Center for Endocrinology, Metabolism, and Nutrition, Kettering Professor of Medicine, Professor of Biochemistry)

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Irvine, R.F., Dawson, R.M.C., Freinkel, N. (1982). Stimulated Phosphatidylinositol Turnover A Brief Appraisal. In: Freinkel, N. (eds) Contemporary Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4187-1_9

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