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Immunological Markers of Human Leukemic Cells of the B Lineage

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Biochemical and Biological Markers of Neoplastic Transformation

Part of the book series: NATO Advanced Science Institutes Series ((NSSA,volume 57))

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Abstract

The study of immunological cell markers in human leukemias and lymphomas has made it possible to establish the nature and origin of the proliferating cells and to demonstrate the heterogeneity of many conditions which appeared previously rather homogeneous to the hematologist. Since leukemic cells usually appear to be frozen at a given stage along the differentiation pathway, these studies have also provided important insights into the biology of the progenitors of hematopoietic cells which correspond to the normal counterpart of the leukemic cell. The maturation arrest characteristic of many human leukemic cells can sometimes be reverted after in vitro stimulation. Such studies may eventually lead to an understanding of crucial differences between the regulation of normal and leukemic cells.

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Author information

Authors and Affiliations

  1. Laboratory of Immunochemistry and Immunopathology (INSERM U 108, Research Institute of Blood Diseases and Laboratory of Oncology and Immunohematology of CNRS), Hôpital Saint-Louis, Paris, France

    M. Seligmann, L. B. Vogler, P. Guglielmi, J. C. Brouet & J. L. Preud’homme

Authors
  1. M. Seligmann
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  2. L. B. Vogler
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  3. P. Guglielmi
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  4. J. C. Brouet
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  5. J. L. Preud’homme
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Editors and Affiliations

  1. University of Frankfurt School of Medicine, Frankfurt am Main, Federal Republic of Germany

    Prakash Chandra

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© 1983 Springer Science+Business Media New York

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Seligmann, M., Vogler, L.B., Guglielmi, P., Brouet, J.C., Preud’homme, J.L. (1983). Immunological Markers of Human Leukemic Cells of the B Lineage. In: Chandra, P. (eds) Biochemical and Biological Markers of Neoplastic Transformation. NATO Advanced Science Institutes Series, vol 57. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4454-4_3

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  • DOI: https://doi.org/10.1007/978-1-4684-4454-4_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4456-8

  • Online ISBN: 978-1-4684-4454-4

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