Skip to main content
SpringerLink
Log in

Changes in T-Lymphocyte Glycoprotein Structures Associated with Differentiation

  • Chapter
Contemporary Topics in Molecular Immunology

Abstract

The problem to be discussed in this chapter is whether changes in the structure of lymphocyte surface glycoproteins—particularly changes in their carbohydrate portions—occur during normal lymphoid differentiation. A positive answer would argue against suggestions (reviewed in Gahmberg, 1981) that the principal role for glycoprotein carbohydrate is a general one, such as stabilizing protein structure, protecting polypeptide chains from proteolysis, or allowing transport of membrane glycoproteins to the cell surface. Information bearing on the problem is available for only a handful of proteins, of which three are major glycoprotein constituents of rodent thymocyte membranes. I will first discuss the identification and properties of these three proteins and then deal with the addition of sialic acid to these and other glycoproteins during T-lymphocyte differentiation; finally, these results will be compared to those obtained by workers studying glycoproteins from erythrocytes (the only other eukaryotic cell type for which comparable information on developmental changes in glycoprotein structure is available).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ades, A. W., Zwerner, R. K, Acton, R. T., and Balch, C. M., 1980,7. Exp. Med. 151:400–406.

    Article  CAS  Google Scholar 

  • Allan, D., and Crumpton, M. J., 1910, Biochem. J. 120:133–143.

    Google Scholar 

  • Altevogt, P., Kurnick, J. T., Kimura, A. K., Bosslet, K., and Schirrmacher, V., 1982, Eur. J. Immunol. 12:300–307.

    Article  PubMed  CAS  Google Scholar 

  • Andersson, L. C., Gahmberg, C. G., Kimura, A. K., and Wigzell, H., 1978, Proc. Natl. Acad. Sci. U.S.A. 75:3455–3458.

    Article  PubMed  CAS  Google Scholar 

  • Atkinson, P. H., and Hakimi, J., 1980, in: The Biochemistry of Glycoproteins and Proteoglycans (W. J. Lennarz, ed.), pp. 191–239, Plenum Press, New York.

    Chapter  Google Scholar 

  • Auchincloss, H., Ozato, K., and Sachs, D. H., 1982, J. Immunol. 128:1584–1589.

    PubMed  Google Scholar 

  • Axelsson, B., Kimura, A., Hammarström, S., Wigzell, H., Nilsson, K., and Mellstedt, H., 1918, Eur. J. Immunol. 8:757–764.

    Article  Google Scholar 

  • Bach, F. H., Alter, G. J., Widmer, M. B., Segal, M., and Dunlap, B., 1981, Immunol. Rev. 54:5–26.

    Article  PubMed  CAS  Google Scholar 

  • Barclay, A. N., Letarte-Muirhead, M., Williams, A. F., and Faulkes, R. A., 1976, Nature (London) 263:563–567.

    Article  CAS  Google Scholar 

  • Bron, C., Schmid, M., Corradin, G., Glasebrook, A. L., Engers, H. D., Horwath, C., Cerottini, J. C., and MacDonald, H. R., 1981, in: Mechanisms of Lymphocyte Activation (K. Resch and H. Kirchner, eds.), pp. 198–201, Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • Brown, W. R. A., and Williams, A. F., 1982, Immunology 46:713–726.

    PubMed  CAS  Google Scholar 

  • Brown, W. R. A., Barclay, A. N., Sunderland, C. A., and Williams, A. F., 1981, Nature (London) 289:456–460.

    Article  CAS  Google Scholar 

  • Campbell, D. G., Gagnon, J., Reid, K. B. M., and Williams, A. F., 1981, Biochem. J. 195: 15–30.

    PubMed  CAS  Google Scholar 

  • Carlsson, S., and Stigbrand, T., 1982, Eur. J. Biochem. 123:1–7.

    Article  PubMed  CAS  Google Scholar 

  • Carter, P. B., and Sunderland, C. A., 1980, Immunogenetics 10:583–593.

    Article  PubMed  CAS  Google Scholar 

  • Childs, R. A., and Feizi,T., 1981,Biochem. Biophys. Res. Commun. 102:1158–1164.

    Article  PubMed  CAS  Google Scholar 

  • Childs, R. A., Feizi, T., and Tonegawa, Y., 1979, Biochem. J. 181:533–538.

    PubMed  CAS  Google Scholar 

  • Coffman, R. L., and Weissman, I. L., 1981,J. Exp. Med. 153:269–279.

    Article  PubMed  CAS  Google Scholar 

  • Coffman, R. L., and Weissman, I. L., 1981, Nature (London) 289:681–683.

    Article  CAS  Google Scholar 

  • Cohen, F. E., Novotny, J., Sternberg, M. J. E., Campbell, D. G., and Williams, A. F., 1981, Biochem. 7. 195: 31–40.

    CAS  Google Scholar 

  • Conzelmann, A., Pink, J. R., Acuto, D., Mach, J. P., Dolivo, S., and Nabholz, M., 1980, Eur. J. Immunol. 10:860–868.

    Article  PubMed  CAS  Google Scholar 

  • Cotmore, S. F., Crowhurst, S. A., and Waterfield, M. D., 1981, Eur. J. Immunol. 11:597–603.

    Article  PubMed  CAS  Google Scholar 

  • Crumpton, M. J., and Snary, D., 1974, in: Contemporary Topics in Molecular Immunology,Volume 3 (G. L. Ada, ed.), pp. 27–56, Plenum Press, New York.

    Chapter  Google Scholar 

  • Cullen, S. E., Kindle, C. S., Shreffler, D. C., and Cowing, C., 1981, J. Immunol. 127:1478–1484.

    PubMed  CAS  Google Scholar 

  • Dalchau, R., and Fabre, J. W., 1979,J. Exp. Med. 149:576–591.

    Article  PubMed  CAS  Google Scholar 

  • Dalchau, R., and Fabre, J. W., 1981, J. Exp. Med. 153:753–765.

    Article  PubMed  CAS  Google Scholar 

  • Dalchau, R., Kirkely, J., and Fabre, J. W., 1980, Eur. J. Immunol. 10:737–744; 745–749.

    Article  PubMed  CAS  Google Scholar 

  • de Sousa, M., 1981, Lymphocyte Circulation: Experimental and Clinical Aspects ,Wiley, New York, p. 81.

    Google Scholar 

  • Despont, J.-P., Abel, C. A., and Grey, H. M., 1975, Cell. Immunol. 17:487–494.

    Article  PubMed  CAS  Google Scholar 

  • Dunlap, B., Bach, F. H., and Bach, M. L., 1978, Nature (London) 271:253–255.

    Article  CAS  Google Scholar 

  • Dunlap, B., Mixter, P. F., Koller, B., Watson, A., Widmer, B., and Bach, F. H., 1980, J. Immunol. 125:1829–1831.

    PubMed  CAS  Google Scholar 

  • Fukuda, M., and Fukuda, M. N., 1981, J. Supramol Struc. 17:313–324.

    CAS  Google Scholar 

  • Fukuda, M., Fukuda, M. N., and Hakomori, S., 1979, J. Biol. Chem. 254:3700–3703.

    PubMed  CAS  Google Scholar 

  • Gahmberg, C. G., 1981, in: New Comprehensive Biochemistry ,Volume 1: Membrane Structure (J. B. Finean and R. M. Michell, eds.), pp. 127–160, Elsevier/North-Holland, Amsterdam.

    Chapter  Google Scholar 

  • Gahmberg, C. G., and Andersson, L. C., 1977, J. Biol Chem. 252:5888–5894.

    PubMed  CAS  Google Scholar 

  • Gahmberg, C. G., and Andersson, L. C., 1982, Eur. J. Biochem. 122:581–586.

    Article  PubMed  CAS  Google Scholar 

  • Gahmberg, C. G., Häyry, P., and Andersson, L. C., 1976,J. Cell. Biol. 68:642–653.

    Article  PubMed  CAS  Google Scholar 

  • Glasebrook, A. L., Sarmiento, M., Loken, M. R., Dialynas, D. P., Quintans, J., Eisenberg, L., Lutz, C. T., Wilde, D., and Fitch, F. W., 1981, Immunol. Rev. 54:225–266.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, I. J., and Hayes, C. E., 1978, Adv. Carbohydr. Chem. Biochem. 35:127–340.

    Article  PubMed  CAS  Google Scholar 

  • Hammarström, S., 1972, in: Methods in Enzymology, Volume 28B (V. Ginsburg, ed.), pp. 368–383, Academic Press, New York.

    Google Scholar 

  • Hayman, M. J., andCrumpton, M. J., 1972, Biochem. Biophys. Res. Commun. 47:923–930.

    Article  PubMed  CAS  Google Scholar 

  • Hellström, V., Dillner, M.-L., Hammarström, S., and Perlmann, P., 1916,Scand. J. Immunol 5:45–54.

    Article  Google Scholar 

  • Hoessli, D.,andVassalli,P., 1980, J. Immunol 125:1758–1763.

    PubMed  CAS  Google Scholar 

  • Hoessli, D., Vassalli, P., and Pink, J. R. L., 1980a, Eur. J. Immunol 10:814–821.

    Article  PubMed  CAS  Google Scholar 

  • Hoessli, D., Bron, C., and Pink, J. R. L., 1980b, Nature (London) 283:576–578.

    Article  CAS  Google Scholar 

  • Hoessli, D., Pink, J. R. L., Hooghe, R., Schreier, M., and Vassalli, P., 1982, in: Protides of the Biological Fluids ,Volume 29 (H. Peeters, ed.), pp. 71–74, Pergamon Press, Oxford.

    Google Scholar 

  • Hooghe-Peters, E., and Hooghe, R. J., 1982, J. Neuroimmunol. 2:191–200.

    Article  PubMed  CAS  Google Scholar 

  • Hubbard, S. C., and Ivatt, R. J., 1981, Annu. Rev. Biochem. 50:555–583.

    Article  PubMed  CAS  Google Scholar 

  • IrlĂ©, C., Piguet, P.-F., and Vassalli, P., 1978,J Exp. Med. 148:32–45.

    Article  PubMed  Google Scholar 

  • Judd, W., Poodry, C. A., Broder, S., Friedman, S. M., Chess, L., and Strominger, J. L., 1980, Proc. Natl Acad. Sci. U.S.A. 77:6805–6809.

    Article  PubMed  CAS  Google Scholar 

  • Kaladas, P. M., Kabat, E. A., Kimura, A., and Ersson, B., 1981, Mol. Immunol 18:969–977.

    Article  PubMed  CAS  Google Scholar 

  • Kamarck,M. E., and Gottlieb, P. D., 1980, Mol. Immunol. 17:1117–1127.

    Article  PubMed  CAS  Google Scholar 

  • Kaufmann, Y., and Berke,G., 1981,J Immunol 126:1443–1446.

    PubMed  CAS  Google Scholar 

  • Kimura, A. K., and Wigzell, H., 1978, J. Exp. Med. 147:1418–1434.

    Article  PubMed  CAS  Google Scholar 

  • Kincade, P. W., Lee, G., Watanabe, T., Sun, L., and Scheid, M. P., 1981, J. Immunol 27: 2262–2268.

    Google Scholar 

  • Kornfeld, R., and Kornfeld, S., 1980, in: The Biochemistry of Glycoproteins and Proteoglycans (W. J. Lennarz, ed.), pp. 1–34, Plenum Press, New York.

    Chapter  Google Scholar 

  • Ledbetter, J. A., and Herzenberg, L. A., 1979, Immunol Rev. 47:63–90.

    Article  PubMed  CAS  Google Scholar 

  • Letarte, M., and Meghji, G., 1978, J. Immunol 121:1718–1725.

    PubMed  CAS  Google Scholar 

  • Lotan, R., and Nicolson, G. L., 1979, Biochim. Biophys. Acta 559:329–376.

    Article  PubMed  CAS  Google Scholar 

  • MacDonald, H. R., Mach, J. P., Schreyer, M., Zaech, P., and Cerottini, J. C., 1981, J. Immunol 126:883–886.

    PubMed  CAS  Google Scholar 

  • Michaelson, J., Scheid, M., and Boyse, E. A., 1979 , Immunogenetics 9:193–197.

    Article  CAS  Google Scholar 

  • Morishima, Y., Ogata, S., Collins, N. H., Dupont, B., and Lloyd, K. O., 1982, Immunogenetics 15:529–535.

    Article  PubMed  CAS  Google Scholar 

  • Morrison, M., and Schonbaum, G. R., 1916, Annu. Rev. Biochem. 45:861–888.

    Article  Google Scholar 

  • Neufeld, E. F., and Ashwell, G., 1980, in: The Biochemistry of Glycoproteins and Proteoglycans (W. J. Lennarz, ed.), pp. 241–265, Plenum Press, New York.

    Chapter  Google Scholar 

  • Nilsson, S. F., and Waxdal, M. J., 1976, Biochemistry 15:2698–2705.

    Article  PubMed  CAS  Google Scholar 

  • Omary, M. B., and Trowbridge, I. S., 1980, J. Biol. Chem. 255:1662–1669.

    PubMed  CAS  Google Scholar 

  • Omary, M. B., Trowbridge, I. S., and Battifora, I., 1980a, J. Exp. Med. 152:842–852.

    Article  PubMed  CAS  Google Scholar 

  • Omary, M. B., Trowbridge, I. S., and Scheid, M. P., 1980b, J. Exp. Med. 151:1311–1316.

    Article  PubMed  CAS  Google Scholar 

  • Pink, J. R. L., Fedecka-Bruner, B., Coltey, M., Peault, B. M., and Le Douarin, N. M., 1981, Eur. J. Immunol 11:517–520.

    Article  PubMed  CAS  Google Scholar 

  • Pink, J. R. L., Hoessli, D., Tartakoff, A., and Hooghe, R., 1983, Mol. Immunol ,(in press).

    Google Scholar 

  • Rose, M. L., 1982 Immunology Today 3:6–8.

    Article  Google Scholar 

  • Rose, M. L., and Malchiodi, F., 1981, Immunology 42:583–591.

    PubMed  CAS  Google Scholar 

  • Saito, M., and Osawa, T., 1980, Carbohydr. Res. 78:341–348.

    Article  PubMed  CAS  Google Scholar 

  • Saito, M., Toyoshima, S., and Osawa, T., 1978, Biochem. J. 175:823–831.

    PubMed  CAS  Google Scholar 

  • Sarmiento, M., Glasebrook, A. L., and Fitch, F. W., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:1111–1115.

    Article  PubMed  CAS  Google Scholar 

  • Sarmiento, M., Loken, M. R., and Fitch, F. W., 1981, Hybridoma 1:13–26.

    Article  PubMed  CAS  Google Scholar 

  • Sarmiento, M., Loken, M. R., Trowbridge, I. S., Coffman, R. L., and Fitch, F. W., 1982, J. Immunol 128:1676–1684.

    PubMed  CAS  Google Scholar 

  • Schmidt-Ullrich, R., Mikkelsen, R. B., and Wallach, D. F. H., 1978, J. Biol Chem. 253: 6973–6978.

    PubMed  CAS  Google Scholar 

  • Schreier, M. H., Iscove, N. N., Tees, R., Aarden, L., and von Boehmer, H., 1980, Immunol Rev. 51:315–336.

    Article  PubMed  CAS  Google Scholar 

  • Sharon, N., 1980, in: Progress in Immunology IV (M. Fougereau and J. Dausset, eds.), pp. 254–278, Academic Press, New York.

    Google Scholar 

  • Sharon, N., 1983, Adv. Immunol ,(in press).

    Google Scholar 

  • Siadak, A. W., and Nowinski, R. C., 1980,J. Immunol. 125:1400–1401.

    PubMed  CAS  Google Scholar 

  • Sidman, C. L., Forni, L., Köhler, G., Langhorne, J., and Fischer Lindahl, K., 1980, in: Basel Institute for Immunology Annual Report ,pp. 61–62, Hoffmann-La Roche, Basel.

    Google Scholar 

  • Standring, R., and Williams, A. F., 1978,Biochim. Biophys. Acta 508:85–96.

    Article  PubMed  CAS  Google Scholar 

  • Standring, R., McMaster, W. R Sunderland, C. A., and Williams, A. F., 1978, Eur. J. Immunol. 8:832–839.

    Article  PubMed  CAS  Google Scholar 

  • Stutman, O., 1978, Immunol Rev. 42:138–184.

    Article  PubMed  CAS  Google Scholar 

  • Sunderland, C. A., McMaster, W. R., and Williams, A. F., 1979, Eur. J. Immunol 9:155–159.

    Article  PubMed  CAS  Google Scholar 

  • Thomas, D. G., Calderon, R. A., and Blaxland, L. J., 1978, Nature (London) 275:711–715.

    Article  CAS  Google Scholar 

  • Trowbridge, I. S., 1978,J. Exp. Med. 148:313–328.

    Article  PubMed  CAS  Google Scholar 

  • Trowbridge, I. S., Weissman, I. L, and Bevan, M. J., 1975, Nature (London) 256:652–654.

    Article  CAS  Google Scholar 

  • Trowbridge, I. S., Nilsen-Hamilton, M., Hamilton, R. T., and Bevan, M. J., 1977, Biochem. J. 163:211–217.

    PubMed  CAS  Google Scholar 

  • Trowbridge, I. S., Hyman, R., and Mazauskas, C., 1978, Cell 14:21–32.

    Article  PubMed  CAS  Google Scholar 

  • von Boehmer, H., and Haas, W., 1981, Immunol Rev. 54:27–56.

    Article  Google Scholar 

  • Watson, A., Dunlap, B., and Bach, F. H., 1981, J. Immunol. 127:38–42.

    PubMed  CAS  Google Scholar 

  • Williams, A. F., 1982, Biosci. Rep. 2:277–287.

    Article  PubMed  CAS  Google Scholar 

  • Williams, A. F., and Gagnon, J., 1982. Science 216:696–703.

    Article  PubMed  CAS  Google Scholar 

  • Yogeeswaram, G., and Salk, P. L., 1981, Science 212:1514–1516.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Basel Institute for Immunology, CH-4005, Basel, Switzerland

    J. R. L. Pink

Authors
  1. J. R. L. Pink
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biochemistry Quillen-Dishner College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA

    F. P. Inman

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    T. J. Kindt

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this chapter

Cite this chapter

Pink, J.R.L. (1983). Changes in T-Lymphocyte Glycoprotein Structures Associated with Differentiation. In: Inman, F.P., Kindt, T.J. (eds) Contemporary Topics in Molecular Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4517-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4517-6_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4519-0

  • Online ISBN: 978-1-4684-4517-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation