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Targets for the Design of Antiviral Agents: Targets in Orthomyxoviruses

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Targets for the Design of Antiviral Agents

Part of the book series: NATO ASI Series ((NSSA,volume 73))

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Abstract

To initiate replication influenza viruses bind to sialic acid residues of membrane glycoconjugates and are taken into intracellular vesicles by endocytosis. Fusion of virus membranes and endosomal membranes occurs and virus transcription complexes are transferred to cell nuclei where virus messenger RNAs are synthesized. The translation of these messengers leads to the production of the proteins involved in RNA replication, in virus assembly, and in the release of progeny virus particles from the cell by budding at the plasma membrane. Each of these processes in the replication cycle will be considered in turn to indicate possible targets for inhibitors of virus production.

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Author information

Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London NW7, UK

    J. J. Skehel & D. C. Wiley

  2. Department of Biochemistry, Harvard University, Cambridge, Mass., 0238, USA

    J. J. Skehel & D. C. Wiley

Authors
  1. J. J. Skehel
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  2. D. C. Wiley
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Editor information

Editors and Affiliations

  1. Rega Institute for Medical Research, Catholic University of Leuven, Leuven, Belgium

    E. De Clercq

  2. The University of Birmingham, Birmingham, UK

    R. T. Walker

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© 1984 Springer Science+Business Media New York

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Skehel, J.J., Wiley, D.C. (1984). Targets for the Design of Antiviral Agents: Targets in Orthomyxoviruses. In: De Clercq, E., Walker, R.T. (eds) Targets for the Design of Antiviral Agents. NATO ASI Series, vol 73. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4709-5_5

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  • DOI: https://doi.org/10.1007/978-1-4684-4709-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4711-8

  • Online ISBN: 978-1-4684-4709-5

  • eBook Packages: Springer Book Archive

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