Abstract
It is a well-established, almost universal phenomenon that, during the ontogenesis of the peripheral and central nervous systems of vertebrates, neurons are initially produced in excess and that the subsequent selective neuronal death occurs as a normal event (Cowan, 1973; Jacobson, 1978). The topographically selective regulation of survival is an important mechanism for the formation of the final structure and function of integrated neuronal systems. The possible mechanism(s) involved in the regulation of neuronal survival have mainly been investigated in the peripheral nervous system, which is relatively simply organized, both structurally and functionally, and which is therefore better suited for detailed analysis than the more complex central nervous system.
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Thoenen, H. (1984). Macromolecular Factors Involved in the Regulation of the Survival and Differentiation of Neurons During Development. In: Sharma, S.C. (eds) Organizing Principles of Neural Development. NATO ASI Series, vol 78. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4802-3_6
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DOI: https://doi.org/10.1007/978-1-4684-4802-3_6
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