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Phospholipase-Induced Abnormalities in the Sarcolemma

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Myocardial Ischemia and Lipid Metabolism

Abstract

Phospholipids are the major form of lipid in all cell membranes and their fixed composition and disposition within membranes are genetically predetermined. In combination with other lipids and proteins, phospholipids are responsible for both structural characteristics and functional properties of the biological membranes such as fluidity (1, 2), ionic permeability (3, 4), transport of material across cell membranes (5), activities of a large number of membrane-bound enzymes (6) and receptor-mediated cell responses (7, 8). Phospholipases are the enzymatic systems responsible for the catabolism of membrane phospholipids, and the interplay between these catabolic enzymes and those of anabolic systems determines the turnover rate and maintains the biological properties and fixed composition of these lipids in membranes. Various physiological stimuli (e.g. certain hormone-receptor interactions, increase in intracellular Ca2+, fat absorption, etc.) enhance phospholipid turnover in membranes (8–11). In some disease conditions, membrane phospholipid composition and metabolism are progressively altered resulting in the functional abnormalities of the cell (12–15).

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Author information

Authors and Affiliations

  1. Department of Medicine and Clinical Biochemistry, University of Toronto, Medical Sciences Building, Room 7359, Toronto, Ontario, Canada, M5S 1A8

    N. A. Shaikh, I. Parson & E. Downar

Authors
  1. N. A. Shaikh
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  2. I. Parson
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  3. E. Downar
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Editor information

Editors and Affiliations

  1. University of Brescia, Brescia, Italy

    R. Ferrari  & O. Visioli  & 

  2. School of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA

    A. M. Katz

  3. William S. Middleton Memorial Veteran Hospital, Madison, Wisconsin, USA

    A. Shug

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© 1984 Plenum Press, New York

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Shaikh, N.A., Parson, I., Downar, E. (1984). Phospholipase-Induced Abnormalities in the Sarcolemma. In: Ferrari, R., Katz, A.M., Shug, A., Visioli, O. (eds) Myocardial Ischemia and Lipid Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4865-8_5

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  • DOI: https://doi.org/10.1007/978-1-4684-4865-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4867-2

  • Online ISBN: 978-1-4684-4865-8

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