Abstract
The concept that chemically reactive metabolites of foreign substances could react covalently with cellular constituents to cause biological injury was introduced by J. A. Miller and E. C. Miller almost 40 years ago. 1–3 Since then considerable effort has been spent investigating the chemistry, biochemistry and biological consequences of reactive metabolic intermediates. Our laboratory has been interested in the metabolic activation, covalent binding and hepatotoxicity of two relatively simple organic compounds, bromobenzene and thiobenzamide. Our long term objective has been to determine the identity of their reactive metabolites, the chemistry of their covalent binding to cellular macromolecules and the relationship of the various types of covalent binding events to the biological changes which follow. This report summarizes some of our recent efforts toward these objectives.
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© 1986 Plenum Press, New York
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Hanzlik, R.P. (1986). Chemistry of Covalent Binding: Studies with Bromobenzene and Thiobenzamide. In: Kocsis, J.J., Jollow, D.J., Witmer, C.M., Nelson, J.O., Snyder, R. (eds) Biological Reactive Intermediates III. Advances in Experimental Medicine and Biology, vol 197. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5134-4_3
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DOI: https://doi.org/10.1007/978-1-4684-5134-4_3
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