Abstract
Oxygen tension in tumor tissue can influence the effectiveness of radiation and many chemotherapeutic agents like misonidazole, bleomycin and adriamycin, which kill tumor cells via oxygen-linked metabolic mechanisms. Therefore it is important to improve tumor oxygenation during the course of treatment with either radiation or drugs. Tumor oxygen tension can be influenced by blood flow as well as by the rate of tumor cell oxygen utilization. We have studied the factors that influence tumor cell oxygen utilization (1,2) in vitro and have previously found that pentobarbital sensitizes tumor cells to hyperbaric oxygen breathing (3). Part of the mechanism may involve either inhibition of oxygen utilization or body temperature lowering, which may also produce reoxygenation by inhibition of tumor cell oxygen utilization (4). We have found that the anaesthetic drugs chlorpromazine and stelazine inhibit cellular oxygen utilization (5). The mechanism of action of these drugs may involve alterations in voltage-dependent calcium channels. Therefore we investigated further the possibility that calcium channels were involved in cellular respiration. We have studied the currently used heart attack drugs diltiazem, nifedipine (procardia) and verapamil as well as praziquantel for their effects on tumor cell oxygen utilization in vitro. We have also determined their inhibiting capacity with tumor cells incubated in the presence of succinate and glucose, substrates known to stimulate, in the former case, and to inhibit cellular oxygen utilization in the later case.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. E. Biaglow, M. E. Varnes, B. Jacobson and C. J. Koch, Factors influencing the oxygen consumption and radiation response of cultured mammalian cells, Adv. Expt1. Med. and Bio1 159: 347 (1983).
J. E. Biaglow, M. E. Varnes, B. Jacobson and H. Suit, Control of oxygen utilization in vitro and in vivo: Implications for radiotherapy of tumors, Adv. Exptl. Med. and Biol. 180: 329 (1984).
H. D. Suit, L. Maimonis, T.A. Rich and R.S. Sedlacek, Anaesthesia and efficacy of hyperbaric oxygen in radiation therapy, Brit. J. Radiol. 52: 244 (1979).
J. E. Biaglow, H. D. Suit, R. E. Durand and D. E. Dosoretz, On the mechanism for enhancement of tumor radiation to hyperbaric oxygen in sodium pentobarbital anaesthetized rodents, Adv. Exptl. Med. and Biol. 180: 301 (1984).
M. A. Shenoy, J. E. Biaglow, M. E. Varnes and F. W. Hetzel, Inhibition of cultured human tumor cell oxygen utilization by chlorpromazine, Adv. Exptl. Med. and Biol. 159: 359 (1983).
: S. F. Flaim and R. Zelis (eds.), “Calcium Blockers: Mechanisms of Action and Clinical Applications”, Urban and Schwarzenberg, Baltimore, MD, (1982).
D. K. Norris and H. F. Bradford, On the specificity of verapamil as a calcium channel-blocker, Biochem. Pharmacol. 34: 1953 (1985).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Biaglow, J.E., Varnes, M.E., Jacobson, B., Suit, H.D. (1986). Effect of Calcium Channel Blocking Drugs on Tumor Cell Oxygen Utilization. In: Longmuir, I.S. (eds) Oxygen Transport to Tissue VIII. Advances in Experimental Medicine and Biology, vol 200. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5188-7_71
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5188-7_71
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5190-0
Online ISBN: 978-1-4684-5188-7
eBook Packages: Springer Book Archive