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Control of Surface Sphingomyelinase Activity in Cultured Neuroblastoma Cells

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Enzymes of Lipid Metabolism II

Part of the book series: NATO ASI Series ((NSSA,volume 116))

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Abstract

Sphingomyelinase (sphirogomyelin phosphodiesterase EC 3.1.4.12) catalyses the degradation of sphingomyelin to ceramide and phosphocholine. At least two forms of the enzyme have been described in mammalian tissues1,2. One forr has a neutral pH optimum (pH 7.4) and requires Mg++ for activity2,3. Based on its almost exclusive localization in brain, enrichment in grey matter2,4, increase in activity in parallel with neuronal maturation5, and particularly high activity levels in certain anatomical regions of brain with special physiological functions4, we have postulated a specific role for this enzyme in the special physiological functions-of neural tissue.

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References

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Author information

Authors and Affiliations

  1. Atlantic Research Centre for Mental Retardation, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 4H7

    Devaki V. Mohan Das, Harold W. Cook & Matthew W. Spence

  2. Departments of Pediatrics and Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 4H7

    Devaki V. Mohan Das, Harold W. Cook & Matthew W. Spence

Authors
  1. Devaki V. Mohan Das
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  2. Harold W. Cook
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  3. Matthew W. Spence
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Editor information

Editors and Affiliations

  1. CNRS Center for Neurochemistry and INSERM U44, Louis Pasteur University, Strasbourg, France

    Louis Freysz , Henri Dreyfus  & Raphaël Massarelli ,  & 

  2. Hebrew University-Hadassah School of Medicine, Jerusalem, Israel

    Shimon Gatt

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© 1986 Plenum Press, New York

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Mohan Das, D.V., Cook, H.W., Spence, M.W. (1986). Control of Surface Sphingomyelinase Activity in Cultured Neuroblastoma Cells. In: Freysz, L., Dreyfus, H., Massarelli, R., Gatt, S. (eds) Enzymes of Lipid Metabolism II. NATO ASI Series, vol 116. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5212-9_69

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  • DOI: https://doi.org/10.1007/978-1-4684-5212-9_69

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5214-3

  • Online ISBN: 978-1-4684-5212-9

  • eBook Packages: Springer Book Archive

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