Skip to main content

Blood Leukocyte Natural Killer Activity as an Early Diagnostic Indicator of Leukaemic Relapse

  • Chapter
Histophysiology of the Immune System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 237))

  • 13 Accesses

Abstract

Natural cell mediated immunity is a well-defined system that may play a role in cancer defence. In contrast to specific T-cell mediated immunity, the mediators of natural immunity, Natural Killer (NK) cells, appear to be non-specific and their lytic activity is not restricted by major histocompatibility (MHC) determinants1.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ortaldo J.R. & Herberman R.B., Heterogeneity of natural killer cells. Annu. Rev. Immunol. 2: 359 (1984).

    Article  PubMed  CAS  Google Scholar 

  2. Lanier L.L., Cwirla S., Federspiel N., & Phillips J.H., Human natural killer cells isolated from peripheral blood do not rearrange T cell antigen receptor B chain genes. J. Exp. Med. 163: 209 (1986).

    Article  PubMed  CAS  Google Scholar 

  3. Barada FA. Jr., Kay H.D., Emmons R., Davis J.S., Horwitz DA., Natural cytotoxicity of adherent cells from human blood: role of the Fc receptor. J. Immunol. 125: 865, (1980).

    PubMed  Google Scholar 

  4. Bakacs T., Gergely P., Cornain S., Klein E., Characterization of human lymphocyte subpopulations for cytotoxicity against tumor-derived monolayer cultures. Int. J. Cancer 19: 441, (1977).

    Article  PubMed  CAS  Google Scholar 

  5. Lanier L.L., Le A.M., Phillips J.H., Warner N.L., Babcock G.F., Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu 11 (NK-15) antigens. J. Immunol. 131: 1789, (1983).

    PubMed  CAS  Google Scholar 

  6. Timonen T., Ranki A., Saksela E., Hayry P., Fractionization, morphological and functional characterization of effector cells responsible for human natural killer activity against cell-line targets. Cell. Immunol. 48: 121 (1979).

    Article  PubMed  CAS  Google Scholar 

  7. Sorskaar D., Lie S.O., Forre O., Natural killer cell activity of peripheral blood and bone marrow mononuclear cells from patients with childhood acute lymphoblastic leukemia. Acta. Paediatr. Scand. 74: 433 (1985).

    Article  PubMed  CAS  Google Scholar 

  8. Yates J., Glidewell O., Wiernik P., Cooper M.R., Steinberg D., Dosik H., Levy R., Hoagland C., Henry P., Gottlieb A., Cornell C, Berenberg J., Hutchinson J.L., Raich P., Nissen N., Ellison R.R., Frelick R., James G.W., Falkson G., Silver R.T, Haurani F., Green M., Henderson E., Leone L., Holland J.F., Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: a CALGB study. Blood 60: 454, (1982).

    PubMed  CAS  Google Scholar 

  9. Boyum A., A one-stage procedure for isolation of granulocytes and lymphocytes from human blood. General sedimentation properties of white blood cells in a lg gravity field. Scand. J. Clin. Lab. Invest. 21 (Suppl 97): 51, (1968).

    CAS  Google Scholar 

  10. Andersson L.C., Nilsson K., & Gahmberg CG., K562 — A human erythroleukemic cell line. Int. J. Cancer 23: 143 (1979).

    Article  PubMed  CAS  Google Scholar 

  11. Brunner K.T., Engers H.D., Cerottini J.C., The 51Cr release assay as used for the quantitative measurement of cell-mediated cytolysis in vitro, in: “In vitro methods in cell-mediated and tumor immunity,” Bloom B.R, David J.R, eds., Academic Press, New York (1976).

    Google Scholar 

  12. Dickinson A., Proctor S.J., Jacobs E., Reed M.M., Walker W., Craft A.W., Kernahan J., Natural killer cell activity in childhood acute lymphoblastic leukaemia in remission. Br. J. Haematol. 59: 45 (1985).

    Article  PubMed  CAS  Google Scholar 

  13. Kay N.E, Zarling J.M., Impaired natural killer activity in patients with chronic lymphocytic leukemia is associated with a deficiency of azurophilic cytoplasmic granules in putative NK cells. Blood 63: 305, (1984).

    PubMed  CAS  Google Scholar 

  14. Ruco L.P, Procopio A., Maccallini V., Calogero A., Uccini S., Annino C, Mandelli F., Baroni C.D.: Severe deficiency of natural killer activity in the peripheral blood of patients with hairy cell leukemia. Blood 61: 1132 (1983).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Tratkiewicz, J.A., Szer, J., Boyd, R.L. (1988). Blood Leukocyte Natural Killer Activity as an Early Diagnostic Indicator of Leukaemic Relapse. In: Fossum, S., Rolstad, B. (eds) Histophysiology of the Immune System. Advances in Experimental Medicine and Biology, vol 237. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5535-9_69

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5535-9_69

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5537-3

  • Online ISBN: 978-1-4684-5535-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics