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Part of the book series: NATO ASI Series ((NSSA,volume 152))

Abstract

With the development of monoclonal antibodies, the hope of a magic bullet has been revived. Many therapeutic and diagnostic agents have been linked to monoclonal antibodies in order to add specificity to the process. Few of these combinations have reached their clinical potential. One such proposal deals with the combination of an antibody with a new image enhancing agent, a paramagnetic compound, for use with nuclear magnetic resonance (NMR) imaging. There are a number of ways that a diagnostic image can be enhanced by a chemical (Table 1).

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References

  1. S. M. Larson and J. A. Carrasquillo, The Role of Labeled Antibodies in the Detection and Possible Treatment of Tumors, Curr. Concepts in Diag. Nucl. Med. 1:13–16 (1985).

    Google Scholar 

  2. F. Bloch, W. W. Hansen, M. E. Packard, Nuclear induction, Phys. Rev. 69:127 (1946).

    Article  Google Scholar 

  3. E. M. Purcell, H. C. Torrey, R. V. Pound, Resonance Absorption by Nuclear Magnetic Moments in a Solid, Phys. Rev. 69:37–38 (1946).

    Article  CAS  Google Scholar 

  4. W. C. Eckelman, R. C. Reba, R. E. Gibson, W. J. Rzeszotarski, F. Vieras, J. K. Mazaitis and B. Francis, Receptor-Binding Radiotracers: A Class of Potential Radiopharmaceuticals, J. Nucl. Med. 20:350–357 (1979).

    PubMed  CAS  Google Scholar 

  5. M. Selikson, R. E. Gibson, W. C. Eckelman and R. C. Reba, Calculation of Binding Isotherms When Ligand and Receptor Are in Different Volumes of Distribution, Anal. Biochem. 108, 64–71 (1980).

    Article  PubMed  CAS  Google Scholar 

  6. M. F. Tweedle, W. C. Eckelman and P. Wedeking, Pharmacokinetics and Metabolism of 153-Gadolinium Chelates, Sixth International Symposium on Radiopharmaceutical Chemistry, p.323, Boston, MA (1986) (Abstract).

    Google Scholar 

  7. E. C. Unger, W. G. Totty, D. M. Neufeld, F. L. Otsuka, W. A. Murphy, M. J. Welch, J. M. Connett, G. W. Philpott, Magnetic Resonance Imaging using Gadolinium Labeled Monoclonal Antibody, Invest. Radiol. 20:693–700 (1985).

    Article  PubMed  CAS  Google Scholar 

  8. P. Shreve and A. M. Aisen, Monoclonal Antibodies Labeled with Polymeric Paramagnetic Ion Chelates, Magnetic Resonance in Medicine 336–340 (1986).

    Google Scholar 

  9. A. M. Keenan, J. C. Harbert and S. M. Larson, Monoclonal Antibodies in Nuclear Medicine, J. Nucl. Med. 26:531–537 (1985).

    PubMed  CAS  Google Scholar 

  10. M. T. McNamara, R. L. Ehman, S. C. Quay, A. L. Epstein, H. Schmidt and R. C. Brasch, Alterations of MR Tumor Relaxation Times Using a Paramagnetic-labeled Monoclonal Antibody, Radiology 153:292 (1984).

    Google Scholar 

  11. B. Khaw, V. P. Torchilin, A. L. Kilbanov, H. K. Gold, T. Yasuda, V. N. Smirnov and E. Haber, Modification of Monoclonal Antibody with DTPA-linked synthetic Polymers; Possible Application in Magnetic Resonance Imaging, Abst. 1205, Circulation Vol 72, Supp III — 302 (1985).

    Google Scholar 

  12. W. T. Anderson-Berg, M. Strand, T. E. Lempert, A. E. Rosenbaum and P. M. Joseph, Nuclear Magnetic Resonance and Gamma Camera Tumor Imaging Using Gadolinium-Labeled Monoclonal Antibodies, J. Nucl. Med. 27:829–833 (1986).

    PubMed  CAS  Google Scholar 

  13. S. H. Koenig and R. D. Brown, in: “ESR and NMR of Paramagnetic Species in Biological and Related Systems,” I. Bertini and R. S. Drago, eds., p. 89 (1979).

    Google Scholar 

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© 1988 Springer Science+Business Media New York

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Eckelman, W.C., Tweedle, M., Welch, M.J. (1988). NMR Enhancement with Gd Labeled Antibodies. In: Srivastava, S.C. (eds) Radiolabeled Monoclonal Antibodies for Imaging and Therapy. NATO ASI Series, vol 152. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5538-0_38

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  • DOI: https://doi.org/10.1007/978-1-4684-5538-0_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5540-3

  • Online ISBN: 978-1-4684-5538-0

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