Abstract
Imagine a “magic bullet” for Alzheimer’s Disease, i.e., a therapy that would do more than just halt the degeneration--this novel treatment would restore the atrophied neocortex and perhaps even replace some of the lost information. Such a glamorous cure for Alzheimer’s disease carries with it a hidden requirement, one that has been relatively neglected in this area of research. The addition of cortical tissue late in life will impose new metabolic demands for synthesis of synaptic connections and the associated dendritic and axonal material. In addition, the volume expansion will tend to dilute metabolic support as the existing capillaries are spread apart. For these reasons any significant restoration of functional cortex will have to include some improvement in its metabolic support.
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References
Turner, A. M. and Greenough, W. T. (1985) Differential rearing effects on rat visual cortex synapses. I. Synaptic and neuronal density and synapses per neuron. Brain Research 329, 195–205.
Black, J. E., Sirevaag, A. M. and Greenough, W. T. (1987) Complex experience promotes capillary formation in young rat visual cortex. Neuroscience Letters 83, 351–355.
Weibel, E. R. (1979) Stereolooical Methods Vol. 1. Academic Press, New York.
Weiss, H. R., Buchweitz, E., Murtha, T. J. and Auletta, M., (1985) Quantitative regional determination of morphometric indices of the total and perfused capillary network in the rat brain. Circulation Research 51, 494–503.
Bar, T. (1980) The Vascular System of the Cerebral Cortex. Springer-Verlag, Berlin.
Homer, L. D. (1984) Moments of distributions of distances to the nearest capillary in tissue. Jllicrovascular Research 27, 114–116.
Rowan, R. A. and Maxwell, D. S. (1981) Patterns of vascular sprouting in the postnatal development of the cerebral cortex of the rat. American Journal of Anatomy 160, 247–255.
Sirevaag, A. M. and Greenough, W. T. (1985) Differential rearing effects on rat visual cortex synapses. Il. Synaptic morphometry. Developmental Brain Research 19 215–226.
Sirevaag, A. M. and Greenough, W. T. (1987) Differential rearing effects on rat visual cortex synapses. Ill. Neuronal and glial nuclei, boutons, dendrites, and capillaries. Developmental Brain Research 424 320–332.
Mata, M., Fink, D. J., Gainer, H., Smith, C. B., Davidsen, L., Savaki, H., Schwartz, W. J. and Sokoloff, L. (1980) Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. Journal of Neurochemistry 34 213–215.
Sirevaag, A. M., Black, J. E., Shafron, D. and Greenough, W. T. (1988) Direct evidence that complex experience increases capillary branching and surface area in visual cortex of young rats. Developmental Brain Research 43 299–304.
Black, J. E., Zelazny, A. M. and Greenough, W. T. (1988) Complex experience induces capillary formation in visual cortex of adult rats. Society for Neuroscience Abstracts 14 1135.
Hwang, H.-M. and Greenough, W. T. (1986) Synaptic plasticity in adult occipital cortex following short-term, long-term and reversal of differential housing complexity. Society for Neuroscience Abstracts 12 1284.
Black, J. E., Parnisari, R., Eichbaum, E. and Greenough, W. T. (1986) Morphological effects of housing environment and exercise on cerebral cortex and cerebellum of old rats. Society for Neuroscience Abstracts 12 1579.
Conner, J. R., Melone, J. H., Yeun, A. and Diamond, M. C. (1981) Dendritic length in aged rat’s occipital cortex: An environmentally induced response. Experimental Neuroloay73 827–830.
Diamond, M. C., Johnson, R. E., Protti, A. M. Ott, C. and Kajisa, L. (1985). PLasticity in the 904-day-old male cerebral cortex. Experimental Neurology 87, 309–317.
Black, J. E., Polinsky, M. and Greenough, W. T. (1989) Progressive failure of cerebral angiogenesis supporting neural plasticity in aging rats. Neurobioloay of Asina in press.
Black, J. E., Jones, A. L., Anderson, B. J., Isaacs, K. R., Alcantara, A. A. and Greenough, W. T. (1987) Cerebellar Plasticity: Preliminary evidence that learning, rather than repetitive motor exercise, alters cerebellar cortex thickness in middle-aged rats. Society for Neuroscience Abstracts 13 1596.
Anderson, B. J., Isaacs, K. R., Black, J. E., Vinci, L., Alcantara, A. A. and Greenough, W. T. (1988) Synaptogenesis in cerebellar cortex after less than 15 hours of visuomotor training over 30 days. Society for Neuroscience Abstracts 14 1135.
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© 1989 Plenum Press, New York
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Black, J.E., Greenough, W.T. (1989). Metabolic Support of Neural Plasticity: Implications for the Treatment of Alzheimer’s Disease. In: Meyer, E.M., Simpkins, J.W., Yamamoto, J. (eds) Novel Approaches to the Treatment of Alzheimer’s Disease. Advances in Behavioral Biology, vol 36. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5727-8_15
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DOI: https://doi.org/10.1007/978-1-4684-5727-8_15
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